Faculty

Elizabeth A Grice, Ph.D.

faculty photo
The Sandra J. Lazarus Professor in Dermatology
Department: Dermatology

Contact information
421 Curie Blvd
1015 BRB II/III
Philadelphia, PA 19104
Office: 215-898-3179
Lab: 215-573-1095
Education:
B.A. (Biology)
Luther College, 2001.
Ph.D. (Human Genetics)
Johns Hopkins University, 2006.
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Description of Research Expertise

Research Interests:
Skin microbiome; cutaneous host-microbe interactions; wound healing

Research Description:
The skin is a formidable barrier and the first line of defense against the external environment. The skin is also colonized with microbial communities, which we hypothesize have critical functions in cutaneous health and disease. These functions may include but are not limited to colonization resistance to block invasion by opportunistic or pathogenic microbiota and regulation of immunity and inflammation. Various cutaneous disorders and infections are hypothesized to in part result from dysregulation of microbiota-host interactions. The Grice lab applies a variety of different approaches, model systems, and human tissues and isolates to elucidate mechanisms regulating such interactions.

Currently, research in the laboratory is divided into the following focus areas:

(1) Skin microbiome regulation of epithelial defense

(2) Microbial regulation of tissue repair and inflammation in chronic wounds

(3) Skin microbiota-driven mechanisms of colonization resistance to pathogens

Selected Publications

Cain CL, White E, Citron LE, Zheng Q, Morris DO, Grice EA, Bradley CW 2nd.: Longitudinal evaluation of the cutaneous and rectal microbiota of German shepherd dogs with perianal fistulas undergoing therapy with ciclosporin and ketoconazole. Vet Dermatol Apr 2024.

Harris JC, Trigg NA, Goshu B, Yokoyama Y, Dohnalová L, White EK, Harman A, Murga-Garrido SM, Ting-Chun Pan J, Bhanap P, Thaiss CA, Grice EA, Conine CC, Kambayashi T.: The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally. Cell Rep 43: 114029, Apr 2024.

Wei M, Knight SA, Fazelinia H, Spruce L, Roof J, Chu E, Walsh J, Flowers L, Kim DY, Zhu J, Grice EA.: An exploration of mechanisms underlying Desemzia incerta colonization resistance to methicillin-resistant Staphylococcus aureus on the skin. mSphere 9: e0063623, March 2024.

Singh TP, Farias Amorim C, Lovins VM, Bradley CW, Carvalho LP, Carvalho EM, Grice EA, Scott P.: Regulatory T cells control Staphylococcus aureus and disease severity of cutaneous leishmaniasis. J Exp Med 220: e20230558, Dec 2023.

Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol Nov 2023.

Wei M, Knight SAB, Flowers L, Walsh J, Grice E.: Complete genome sequence of the bacterium Desemzia incerta isolated from the dorsal skin of a Yucatan pig. Microbiol Resour Announc 12: e0051923, Nov 2023.

Hajfathalian M, de Vries CR, Hsu JC, Amirshaghaghi A, Dong YC, Ren Z, Liu Y, Huang Y, Li Y, Knight SA, Jonnalagadda P, Zlitni A, Grice EA, Bollyky PL, Koo H, Cormode DP.: Theranostic gold-in-gold cage nanoparticles enable photothermal ablation and photoacoustic imaging in biofilm-associated infection models. J Clin Invest 133: e168485, Nov 2023.

Campbell AE, McCready-Vangi AR, Uberoi A, Murga-Garrido SM, Lovins VM, White EK, Pan JT, Knight SAB, Morgenstern AR, Bianco C, Planet PJ, Gardner SE, Grice EA.: Variable staphyloxanthin production by Staphylococcus aureus drives strain-dependent effects on diabetic wound-healing outcomes. Cell Rep 42: 113281, Oct 2023.

Farias Amorim C, Lovins VM, Singh TP, Novais FO, Harris JC, Lago AS, Carvalho LP, Carvalho EM, Beiting DP, Scott P, Grice EA.: Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity. Sci Transl Med 15: eadh1469, Oct 2023.

Margolis DJ, Chiesa Fuxench ZC, Hoffstad OJ, Grice EA, Mitra N.: Pregnant Females with Atopic Dermatitis Are More Likely to be Colonized with Group B Streptococci. J Invest Dermatol Aug 2023.

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Last updated: 04/15/2024
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