Faculty

Katherine Uyhazi, MD, PhD

Assistant Professor of Ophthalmology

Department: Ophthalmology

Graduate Group Affiliations

Contact information

Stellar Chance Laboratories, Rm 313A
422 Curie Blvd
Philadelphia, PA 19104

Office: (215) 662-8816

Email:
katherine.uyhazi@pennmedicine.upenn.edu

Education:
B.S (Biology)
The College of New Jersey, 2005.
M.D/Ph.D. (Cell Biology)
Yale School of Medicine, 2013.

Links
Uyhazi Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Inherited retinal degenerations
Retinitis pigmentosa
Stargardt disease
Cone rod dystrophy
Leber congenital amaurosis
Gyrate atrophy
Electroretinography (ERG)
Genetic testing

Description of Research Expertise

Retinal gene therapy
Stem cell therapy
Retinal regeneration
Photoreceptor development
Subretinal injections
Induced Pluripotent Stem Cells (iPSCs)
Murine models of eye disease
Single cell RNA sequencing (scRNAseq)
Retinal histology

Selected Publications

Wilder RJ, An AF, Bell BA, Fossett G, Wojciechowski AM, Shpylchak I, Uyhazi KE.: Intraretinal variation in disease severity in the Oat(rhg) mouse model of gyrate atrophy. Exp Eye Res April 2025.

Yano JJ, Wei Z, Uyhazi KE: Lineage Tracing Photoreceptor Precursor Cells During Murine Retinal Development. Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting (Salt Lake City, UT) 2025 Notes: Poster.

Wilder RJ, An AF, Bell B, Fossett G, Wojciechowski A, Uyhazi KE: Intraretinal variation in disease severity in the OAT-rhg mouse model of gyrate atrophy. Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting (Salt Lake City, UT) 2025 Notes: Poster.

Aleman TS, Cideciyan AV, Uyhazi KE, Weber ML, Roman AJ, Swider M, Sumaroka A, Maguire KH, Aleman EM, O'Neil EC, Santos A, Kim RJ, Parchinski KM, Fradin M, Chung W, Margaritis P, Sun J, Scoles DH, Wu V, Garafalo AV, Jayagopal A, Yerxa B, Tuller S, Maguire AM, Bennett J.: Recovery of Cone-Mediated Vision in a Severe Ciliopathy after Gene Augmentation One Year Results of a Phase I/II Trial for LCA5-LCA. Association for Research in Vision and Ophthalmology (ARVO) 2025 Annual Meeting (Salt Lake City, UT) 2025.

Aleman TS, Uyhazi KE, Roman AJ, zWeber ML, Swider MM, Sumaroka A, Maguire KH, Aleman EM, O'Neil EC, Santos AJ, Kim RJ, Parchinski KM, Billek A, Fradin M, Chung W, Margaritis P, Sun J, Scoles DH, Wu V, Garafalo AV, Jayagopal A, Yerxa B, Tuller S, Maguire AM, Bennett J, Cideciyan AV.: Recovery of Cone-Mediated Vision in a Severe Ciliopathy after Gene Augmentation One Year Results of a Phase I/II Trial for LCA5-LCA. Molecular Therapy 2025.

Passino R, Bell B, Uyhazi KE: Microglia Inhibition Improves Gene Therapy in a Mouse Model of Photoreceptor Degeneration. 152nd Anniversary Meeting of the Scheie Eye Institute (Philadelphia, PA) 2025 Notes: Poster.

Aleman TS, Roman AJ, Uyhazi KE, Jiang YY, Bedoukian EC, Sumaroka A, Wu V, Swider M, Viarbitskaya I, Russell RC, Shagena EO, Santos AJ, Serrano LW, Parchinski KM, Kim RJ, Weber ML, Garafalo AV, Thompson DA, Maguire AM, Bennett J, Scoles DH, O'Neil EC, Morgan JIW, Cideciyan AV.: Retinal Degeneration Associated With Biallelic RDH12 Variants: Longitudinal Evaluation of Retinal Structure and Visual Function in Pediatric Patients. Invest Ophthalmol Vis Sci 65: 30, Dec 2024.

Yano JJ, Wei Z, Uyhazi KE.: Lineage Tracing Photoreceptor Precursor Cells in the Murine Retina. 2025 Mid-Atlantic Society for Developmental Biology (SDB) Regional Meeting (College Park, MD). 2024.

Yano JJ, Wei Z, Bell BA, Uyhazi KE: Characterizing Photoreceptor Precursor Cells During Murine Retinal Development. 2024 Mid-Atlantic Society for Developmental Biology (SDB) Regional Meeting (College Park, MD). 2024.

Bedoukian E, Bennett J, Uyhazi KE, Maguire AM, O’Neil EC, Krauss E, Roman AJ, Sumaroka A, Swider M, Scoles D, Garafalo AV, Cideciyan AV, Aleman TS: Treatment Potential of RPGRIP1-associated Inherited Retinal Degenerations. Association for Research in Vision and Ophthalmology (ARVO) 2024 Annual Meeting (Seattle, WA). Notes: Poster #A0063. 2024.