Eric F. Joyce, Ph.D.

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Assistant Professor of Genetics
Department: Genetics

Contact information
564 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
Office: 215-898-1229
Lab: 215-746-5734
B.A. (Genetics and Microbiology)
Rutgers University, 2004.
Ph.D. (Microbiology and Molecular Genetics)
Rutgers University, 2010.
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Description of Research Expertise

The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.

Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization

Rotation Projects: Please contact Eric for more details.

Selected Publications

Rosin Leah F, Nguyen Son C, Joyce Eric F: Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei. PLoS genetics 14(7): e1007393, Jul 2018.

Joyce Eric F: Toward High-Throughput and Multiplexed Imaging of Genome Organization. Assay and drug development technologies 15(1): 11-14, Jan 2017.

Senaratne T Niroshini, Joyce Eric F, Nguyen Son C, Wu C-Ting: Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei. PLoS genetics 12(8): e1006169, Aug 2016.

Gyuricza Mercedes R, Manheimer Kathryn B, Apte Vandana, Krishnan Badri, Joyce Eric F, McKee Bruce D, McKim Kim S: Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation. Current biology Jun 2016.

Joyce Eric F, Erceg Jelena, Wu C-Ting: Pairing and anti-pairing: a balancing act in the diploid genome. Current opinion in genetics & development 37: 119-128, Apr 2016.

Beliveau, B. J., Boettiger, A. N., Avendano, M. S., Jungmann, R., McCole, R. B., Joyce, E. F., Kim-Kiselak, C., Bantignies, F., Fonseka, C. Y., Erceg, J., Hannan, M. A., Hoang, H. G., Colognori, D., Lee, J. T., Shih, W. M., Yin, P., Zhuang, X., Wu, C. T.: Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Nat Commun 6: 7147, 2015 Notes: doi: 10.1038/ncomms8147.

Joyce, E. F., Apostolopoulos, N., Beliveau, B. J., Wu, C. T.: Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development. PLoS Genet 9(12): e1004013, 2013.

Beliveau, B. J., Joyce, E. F., Apostolopoulos, N., Yilmaz, F., Fonseka, C. Y., McCole, R. B., Chang, Y., Li, J. B., Senaratne, T. N., Williams, B. R., Rouillard, J. M., Wu, C. T.: Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes. Proc Natl Acad Sci U S A 109(52): 21301-6, 2012.

Joyce, E. F., Williams, B. R., Xie, T., Wu, C. T.: Identification of genes that promote or antagonize somatic homolog pairing using a high-throughput FISH-based screen. PLoS Genet 8(5): e1002667, 2012.

Joyce, E. F., Pedersen, M., Tiong, S., White-Brown, S. K., Paul, A., Campbell, S. D., McKim, K. S.: Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. J Cell Biol 195(3): 359-67, 2011.

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Last updated: 12/05/2018
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