Faculty

Kiran Musunuru, MD, PhD, MPH, ML

Professor of Medicine

Department: Medicine

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

3400 Civic Center Blvd, Bldg 421
11-104 Smilow Center for Translational Research
Philadelphia, PA 19104

Office: 215-573-4717

Email:
kiranmusunuru@gmail.com

Education:
AB (Biochemical Sciences)
Harvard College, Cambridge, MA, 1997.
PhD (Biomedical Sciences)
The Rockefeller University, New York, NY, 2003.
MD (Medicine)
Weill-Cornell Medical College, New York, NY, 2004.
MPH (Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2009.
ML (Law)
University of Pennsylvania Law School, Philadelphia, PA, 2019.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Bose SK, White BM, Kashyap MV, Dave A, De Bie FR, Li H, Singh K, Menon P, Wang T, Teerdhala S, Swaminathan V, Hartman HA, Jayachandran S, Chandrasekaran P, Musunuru K, Jain R, Frank DB, Zoltick P, Peranteau WH.: In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease. Nat Commun 12: 4291, Jul 2021.

Parcha V, Patel N, Musunuru K, Margulies KB, Cappola TP, Halade G, Wang TJ, Arora G, Arora P.: Natriuretic peptide deficiency in obese individuals: mechanistic insights from healthy organ donor cohort. J Am Coll Cardiol 77: 3138-3140, Jun 2021.

Musunuru K, Chadwick AC, Mizoguchi T, Garcia SP, DeNizio JE, Reiss CW, Wang K, Iyer S, Dutta C, Clendaniel V, Amaonye M, Beach A, Berth K, Biswas S, Braun MC, Chen HM, Colace TV, Ganey JD, Gangopadhyay SA, Garrity R, Kasiewicz LN, Lavoie J, Madsen JA, Matsumoto Y, Mazzola AM, Nasrullah YS, Nneji J, Ren H, Sanjeev A, Shay M, Stahley MR, Fan SHY, Tam YK, Gaudelli NM, Ciaramella G, Stolz LE, Malyala P, Cheng CJ, Rajeev KG, Rohde E, Bellinger AM, Kathiresan S.: In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates. Nature 593: 429-434, May 2021.

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell 28: 938-954, May 2021.

Parcha V, Patel N, Gutierrez OM, Li P, Gamble KL, Musunuru K, Margulies KB, Cappola TP, Wang TJ, Arora G, Arora P.: Chronobiology of natriuretic peptides and blood pressure in lean and obese individuals. J Am Coll Cardiol 77: 2291-2303, May 2021.

Sandrone S, Scott G, Anderson WJ, Musunuru K.: Active learning-based STEM education for in-person and online learning. Cell 184: 1409-1414, Mar 2021.

Musunuru, K: Genome Editing: A Practical Guide to Research and Clinical Applications. Mar 2021.

Musunuru K.: Treating coronary artery disease: beyond statins, ezetimibe, and PCSK9 inhibition. Annu Rev Med 72: 447-458, Jan 2021.

Musunuru K.: Adenine base editing to treat progeria syndrome and extend the lifespan. J Cardiovasc Aging 1: 8, 2021.

Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, Hynes RO, Ishii T, Kiani S, Lee LH, Levrier G, Liu DR, Lunshof JE, Macintosh KL, Mathews DJH, Meslin EM, Mills PHR, Montoliu L, Musunuru K, Nicol D, O'Neill H, Qiu R, Ranisch R, Sherkow JS, Soni S, Terry S, Topol E, Williamson R, Zhang F, Davies K.: Reactions to the National Academies/Royal Society Report on Heritable Human Genome Editing. CRISPR J 2: 356-358, Dec 2020.