De'Broski R. Herbert, PhD

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Graduate Group Affiliations

Contact information
BS (Microbiology)
Xavier University of Louisiana, 1994.
PhD (Immunology)
Thomas Jefferson University, 2000.
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Description of Research Expertise

regulatory networks, immunity, inflammation, tissue repair, mucosal interface

Through the study of parasitic helminths and protozoa, my group has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract.

Selected Publications

Nieves, W., Hung, L. Y., Oniskey, T. K., Boon, L., Foretz, M., Viollet, B., Herbert, D. R.: Myeloid-Restricted AMPKα1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection. J Immunol 196(11): 4632-4640, 2016.

Chan, P. Y., Carrera Silva, E. A., De Kouchkovsky, D., Joannas, L. D., Hao, L., Hu, D., Huntsman, S., Eng, C., Licona-Limón, P., Weinstein, J. S., Herbert, D. R., Craft, J. E., Flavell, R. A., Repetto, S., Correale, J., Burchard, E. G., Torgerson, D. G., Ghosh, S., Rothlin, C. V.: The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352(6281): 99-103, 2016.

Nair, M. G., Herbert, D. R.: Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages. Immunology 148(2): 115-124, 2016.

Karo-Atar, D., Bordowitz, A., Wand, O., Pasmanik-Chor, M., Fernandez, I. E., Itan, M., Frenkel, R., Herbert, D. R., Finkelman, F. D., Eickelberg, O., Munitz, A.: A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal Immunol 9(1): 240-253, 2016.

Hung, L. Y., Sen, D., Oniskey, T. K., Nieves, W., Urisman, A., Krummel, M. F., Herbert, D. R.: Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression. J Immunol 196, 2016.

Fontana, M. F., Baccarella, A., Kellar, D., Oniskey, T. K., Terinate, P., Rosenberg, S. D., Huang, E. J., Herbert, D. R., Kim, C. C.: Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections. Parasite Immunol 37(9): 470-478, 2015.

Fontana, M. F., Baccarella, A., Pancholi, N., Pufall, M. A., Herbert, D. R., Kim, C. C.: JUNB is a key transcriptional modulator of macrophage activation. J Immunol 194(1): 177-186, 2015.

Herbert, D., Hung, L. Y., Sen, D., Oniskey, T., Kim, C., Krummel, M.: Trefoil factor 2 maintains and restores pulmonary function via promoting epithelial repair and M2 activation. J Immunol 192, 2014.

McBerry, C., Dias, A., Shryock, N., Lampe, K., Gutierrez, F. R., Boon, L., De'Broski, R. H., Aliberti, J.: PD-1 modulates steady-state and infection-induced IL-10 production in vivo. Eur J Immunol 44(2): 469-479, 2014.

Apiwattanakul, N., Thomas, P. G., Kuhn, R. E., Herbert, D. R., McCullers, J. A.: Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens. Med Microbiol Immunol 203(5): 357-364, 2014.

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Last updated: 07/26/2022
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