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Kyla Ortved, DVM, PhD, DACVS, DACVSMR
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Graduate Group Affiliations
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Contact information
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382 W. Street Road
Kennett Square, PA 19348
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Kennett Square, PA 19348
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Office: 610-925-6195
3e Lab: 610-925-6255
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Email:
kortved@vet.upenn.edu
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kortved@vet.upenn.edu
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Publications
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Education:
21 a B.Sc. 1b (Animal Biology) c
37 University of British Columbia, 2001.
21 8 DVM 20 (Veterinary Medicine) c
2d University of Guelph, 2006.
21 8 PhD 2c (Comparative Biomedical Sciences) c
2b Cornell University, 2014.
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21 a B.Sc. 1b (Animal Biology) c
37 University of British Columbia, 2001.
21 8 DVM 20 (Veterinary Medicine) c
2d University of Guelph, 2006.
21 8 PhD 2c (Comparative Biomedical Sciences) c
2b Cornell University, 2014.
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Links
7f Search PubMed for articles
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Permanent link7f Search PubMed for articles
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17 Fracture repair
13 Arthroscopy
12 Tenoscopy
1c Regenerative medicine
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Description of Clinical Expertise
2a Equine orthopedic surgery17 Fracture repair
13 Arthroscopy
12 Tenoscopy
1c Regenerative medicine
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Description of Research Expertise
222 Establishing regenerative therapies to improve musculoskeletal healing using the horse as a model for human disease. Specifically, my research program is targeted towards developing gene and cell therapies to improve cartilage repair and prevent osteoarthritis; establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects; elucidating the pathophysiology of posttraumatic osteoarthritis; and adeno-associated virus mediated overexpression of immunomodulatory cytokines in the joint.e 29
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140 Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF: Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis. EVJ 49: 590-599, 2021.
106 Boorman S, Hofmeister EH, Ross MW, Ralston S, Bell S, Mackie S, Ortved KF: Osteochondrosis decreases the longevity and racing performance of Standardbred trotters and pacers. Vet Surg 2021.
105 Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C: Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support. Tribology Letters 2021.
113 Farnham M, Ortved KF, Burris DL, Price C: Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions. Cellular and Molecular Bioengineering 2021.
12d Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF: Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro. Vet Immunol Immunopathol 2021.
137 Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE: Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy. Human Gene Therapy 2021.
156 Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JE, Ortved KF: Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model. Frontiers Vet Sci 8:a697551, 2021.
15a Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF: Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome. Vet Surg 51: 426-437, 2022.
100 Redding LE, Elzer EJ, Ortved KF: Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: a meta-analysis. PLoS One 17:e0265971, 2022.
167 Even KM, Gaesser AM, Ciamillo SA, Linardi RL, Ortved KF: Comparing the immunomodulatory properties of equine BM-MSCs culture expanded in autologous platelet lysate, pooled platelet lysate, equine serum and fetal bovine serum supplemented culture media. Frontiers Vet Sci 9:958724, 2022.
159 Ciamillo SA, Pownder SL, Potter HG, Stefanovski D, Nixon AJ, Ortved KF. : Correlation of magnetic resonance imaging (MRI) and optical coherence tomography (OCT) with healing of cartilage defects implanted with chondrocytes overexpressing IGF-I. online ahead of print 2023.
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Selected Publications
121 Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF: The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells. Stem Cells Dev 29: 144-155, 2020.140 Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF: Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis. EVJ 49: 590-599, 2021.
106 Boorman S, Hofmeister EH, Ross MW, Ralston S, Bell S, Mackie S, Ortved KF: Osteochondrosis decreases the longevity and racing performance of Standardbred trotters and pacers. Vet Surg 2021.
105 Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C: Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support. Tribology Letters 2021.
113 Farnham M, Ortved KF, Burris DL, Price C: Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions. Cellular and Molecular Bioengineering 2021.
12d Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF: Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro. Vet Immunol Immunopathol 2021.
137 Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE: Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy. Human Gene Therapy 2021.
156 Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JE, Ortved KF: Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model. Frontiers Vet Sci 8:a697551, 2021.
15a Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF: Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome. Vet Surg 51: 426-437, 2022.
100 Redding LE, Elzer EJ, Ortved KF: Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: a meta-analysis. PLoS One 17:e0265971, 2022.
167 Even KM, Gaesser AM, Ciamillo SA, Linardi RL, Ortved KF: Comparing the immunomodulatory properties of equine BM-MSCs culture expanded in autologous platelet lysate, pooled platelet lysate, equine serum and fetal bovine serum supplemented culture media. Frontiers Vet Sci 9:958724, 2022.
159 Ciamillo SA, Pownder SL, Potter HG, Stefanovski D, Nixon AJ, Ortved KF. : Correlation of magnetic resonance imaging (MRI) and optical coherence tomography (OCT) with healing of cartilage defects implanted with chondrocytes overexpressing IGF-I. online ahead of print 2023.
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