Zachary T Schug, Ph.D.

faculty photo
Adjunct Assistant Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Room 533
Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104
Office: 6098207478
Lab: 2158983705
Education:
B.S. (Biology)
Saint Joseph's University, 2001.
Ph.D. (Molecular Cell Biology)
Thomas Jefferson University, 2007.
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Description of Research Expertise

Cancer Metabolism
Metabolomics
Lipidomics
Acetate Metabolism
Lipid Metabolism
Functional Genomics
Synthetic Lethality

Selected Publications

Schug ZT: Formaldehyde Detoxification Creates a New Wheel for the Folate-Driven One-Carbon "Bi"-cycle. Biochemistry 57(6): 889-890, Feb 2018.

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ: Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell Reports 18(3): 647-658, Jan 2017.

Schug ZT, Vande Voorde J, Gottlieb E: The metabolic fate of acetate in cancer. Nature Reviews Cancer. Gemma Arteton (eds.). 16(11): 708-717, Nov 2016.

Goldman AR, Bitler BG, Schug Z, Conejo-Garcia JR, Zhang R, Speicher DW: The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. Mol Cell Proteomics 15(11): 3348-3360, Nov 2016.

Trousil S, Kaliszczak M, Schug Z, Nguyen QD, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, Aboagye EO.: The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget 7(24): 37103-37120, June 2016.

Schug Zachary T, Vande Voorde Johan, Gottlieb Eyal: The Nurture of Tumors Can Drive Their Metabolic Phenotype. Cell metabolism 23(3): 391-2, Mar 2016.

Peck Barrie, Schug Zachary T, Zhang Qifeng, Dankworth Beatrice, Jones Dylan T, Smethurst Elizabeth, Patel Rachana, Mason Susan, Jiang Ming, Saunders Rebecca, Howell Michael, Mitter Richard, Spencer-Dene Bradley, Stamp Gordon, McGarry Lynn, James Daniel, Shanks Emma, Aboagye Eric O, Critchlow Susan E, Leung Hing Y, Harris Adrian L, Wakelam Michael J O, Gottlieb Eyal, Schulze Almut: Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer & metabolism 4: 6, 2016.

Vazquez A, Kamphorst JJ, Markert EK, Schug ZT, Tardito S, Gottlieb E: Cancer metabolism at a glance. J Cell Sci 129(18): 3367-73, 2016.

Patella Francesca, Schug Zachary T, Persi Erez, Neilson Lisa J, Erami Zahra, Avanzato Daniele, Maione Federica, Hernandez-Fernaud Juan R, Mackay Gillian, Zheng Liang, Reid Steven, Frezza Christian, Giraudo Enrico, Fiorio Pla Alessandra, Anderson Kurt, Ruppin Eytan, Gottlieb Eyal, Zanivan Sara: Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability. Molecular & cellular proteomics : MCP 14(3): 621-34, Mar 2015.

Schug Zachary T, Peck Barrie, Jones Dylan T, Zhang Qifeng, Grosskurth Shaun, Alam Israt S, Goodwin Louise M, Smethurst Elizabeth, Mason Susan, Blyth Karen, McGarry Lynn, James Daniel, Shanks Emma, Kalna Gabriela, Saunders Rebecca E, Jiang Ming, Howell Michael, Lassailly Francois, Thin May Zaw, Spencer-Dene Bradley, Stamp Gordon, van den Broek Niels J F, Mackay Gillian, Bulusu Vinay, Kamphorst Jurre J, Tardito Saverio, Strachan David, Harris Adrian L, Aboagye Eric O, Critchlow Susan E, Wakelam Michael J O, Schulze Almut, Gottlieb Eyal: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer cell 27(1): 57-71, Jan 2015.

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Last updated: 09/14/2018
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