Faculty

John T. Seykora, M.D., Ph.D

Professor of Dermatology

Department: Dermatology

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142

Office: 2158980170
Fax: 2155732143

Education:
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.

Links
Faculty web page

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

"Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH: Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome" J Clin Invest 133(1), January 2023 Notes: 2023 Jan 3;133(1):e162137. doi: 10.1172/JCI162137.

Ko K, Merlet J, DerGarabedian B, Zhen H, Suzuki-Horiuchi Y, Hedberg M, Hu E, Nguyen A, Prouty S, Alawi F, Walsh M, Choi Y, Millar S, Cliff A, Romero J, Garvin M, Seykora J*, Jacobson D* and Graves D*-co Senior Authors.: “NF-kB Perturbation Reveals Unique Immunomodulatory Functions in Prx1+ Fibroblasts that Promote Atopic Dermatitis” . Sci Transl Med 14(630), February 2022 Notes: 2022 Feb 2;14(630):eabj0324. doi: 10.1126/scitranslmed.abj0324. Epub 2022 Feb 2.

Modi MB, Pei S, Hedberg ML, Fischer AS, Guerrero J, Carreon CK, Cooper K, Seykora JT: "Clinical, pathologic, and molecular analyses of superficial low-grade fibromyxoid sarcoma in two young patients: A rare and deceptive mimic of benignancy" J Cutan Pathol February 2022 Notes: 2022 Feb 22. doi: 10.1111/cup.14215. Epub ahead of print.

Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T: “Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion” Science 30(373): 6554, July 2021 Jul 30;373(6554.

Aguirre-Portolés C., Payne R., Trautz A., Foskett J.K., Natale C.A., Seykora J.T., Ridky T.W.: ZIP9 is a Druggable Determinant of Sex Differences in Melanoma" Cancer Res 81(23): 5991-6003, December 2021 Notes: doi: 10.1158/0008-5472.CAN-21-0982. Epub 2021 Oct 27.

Lee V, Griffin TD, Suzuki-Horiuchi Y, Wushanley L, Kweon Y, Marshall C, Li W, Ayli E, Haimovic A, Hines A, Seykora JT: “Downregulation of Src-family tyrosine kinases by Srcasm and c-Cbl: a comparative analysis” J of Carcinog 20(21), October 2021 Notes: doi: 10.4103/jcar.jcar_13_21.

Hedberg M, Seykora JT: "Clarifying Progress on the Genomic Landscape of Actinic Keratosis" J Invest Dermatol 141(7): 1622-1624, July 2021 Notes: doi: 10.1016/j.jid.2021.02.761.

Zhu X, Leboeuf M, Liu F, Grachtchouk M, Seykora JT, Morrisey EE, Dlugosz AA, Millar SE: "HDAC1/2 control proliferation and survival in adult epidermis and pre-basal cell carcinoma via p16 and p53" J Invest Dermatol Epub ahead of print, July 2021 Notes: 2021 Jul 17:S0022-202X(21)01438-X. doi: 10.1016/j.jid.2021.05.026. Epub ahead of print.

Roche FC, Fischer AS, Gaddis KJ, Dentchev T, Taylor SC, Cotsarelis G, Seykora JT: Fibrotic Trochanters: "Central centrifugal cicatricial alopecia: A Potential Mechanism for Stem Cell Depletion in Scarring Alopecias” J Cutan Pathol 48(3): 458-460, March 2021.

Roche FC, Fischer AS, Williams D, Ogunleye T, Seykora JT, Taylor SC: "Central centrifugal cicatricial alopecia: Histologic progression correlates with advancing age" J Am Acad Dermatol January 2021 Notes: 2021 Jan 17:S0190-9622(21)00173-0. doi: 10.1016/j.jaad.2021.01.028. Epub ahead of print.