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John T. Seykora, M.D., Ph.D
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Professor of Dermatology
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Department: Dermatology
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Graduate Group Affiliations
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Contact information
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Department of Dermatology
2f Room 1011, Biomedical Research Building
36 421 Curie Blvd
Philadelphia, PA 19104-6142
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2f Room 1011, Biomedical Research Building
36 421 Curie Blvd
Philadelphia, PA 19104-6142
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Office: 2158980170
3e Lab: 215 573 5063
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3e Lab: 215 573 5063
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Publications
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Education:
21 9 B.A. 20 (Biology with Honors) c
2e University of Chicago, 1986.
21 9 M.S. 19 (Biochemistry) c
2e University of Chicago, 1986.
21 a Ph.D. 19 (Cell Biology) c
2f Rockefeller University, 1992.
21 9 M.D. 15 (Medicine) c
3b Cornell University Medical College, 1993.
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Permanent link21 9 B.A. 20 (Biology with Honors) c
2e University of Chicago, 1986.
21 9 M.S. 19 (Biochemistry) c
2e University of Chicago, 1986.
21 a Ph.D. 19 (Cell Biology) c
2f Rockefeller University, 1992.
21 9 M.D. 15 (Medicine) c
3b Cornell University Medical College, 1993.
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48 2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
45 3. Signal transduction-tyrosine kinases and adaptor molecules
2b 4. Murine models of human diseases.
38 5. Use of organotypic cultures to model disease.
2a 6. Effects of UVB on keratinocytes
14 7. Psoriasis
40 8. Dermatopathology-alopecia, appendageal tumors, cancer.
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57 1. Alopecias-including analysis via horizontal sections or the HoVert Technique
20 2. Appendageal neoplasms
1e 3. Melanocytic lesions
2d 4. Molecular analysis of biopsy tissue
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Description of Research Expertise
58 1. Keratinocyte growth and differentiation-mechanisms of growth control48 2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
45 3. Signal transduction-tyrosine kinases and adaptor molecules
2b 4. Murine models of human diseases.
38 5. Use of organotypic cultures to model disease.
2a 6. Effects of UVB on keratinocytes
14 7. Psoriasis
40 8. Dermatopathology-alopecia, appendageal tumors, cancer.
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Description of Clinical Expertise
21 Dermatopathology57 1. Alopecias-including analysis via horizontal sections or the HoVert Technique
20 2. Appendageal neoplasms
1e 3. Melanocytic lesions
2d 4. Molecular analysis of biopsy tissue
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13d Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE.: Identification of Meibomian gland stem cell populations and mechanisms of aging. Nat Commun. Feb. 2025.
183 Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE.: Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. Cell Rep. Feb. 2025.
132 Hoffman CL, Bharathan NK, Shibata Y, Giang W, Gudjonsson JE, Seykora JT, Prouty SM, Stahley SN, Payne AS, Kowalczyk AP.: Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response. J Invest Dermatol. Feb. 2025.
1ab Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci Dec. 2024.
14d Grice EA, Brennan-Crispi D, Rodriguez N, Margolis DJ, Seykora JT, Cotsarelis G, Taylor SC, Shuda J. : Penn Academy for Skin Health (PASH): An Experiential Pipeline Program in Skin Biology and Dermatology for High-School Students. J Invest Dermatol. Oct. 2024.
184 Abbott JJ, Jiang AJ, Godse R, Ahmed S, Senft SC, Wilson MA, Cohen JV, Mitchell TC, Ogunleye TA, Higgins HW 2nd, Shin TM, Miller CJ, Roth JJ, Priore SF, Castelo-Soccio L, Elenitsas R, Seykora JT, Nathanson KL, Chu EY: Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants. JAMA Dermatol. Sept. 2024.
167 Sati S, Huang J, Kersh AE, Jones P, Ahart O, Murphy C, Prouty SM, Hedberg ML, Jain V, Gregory SG, Leung DH, Seykora JT, Rosenbach M, Leung TH: Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases. J Clin Invest. Sept. 2024.
f0 Maeno H, Suzuki-Horiuchi Y, Funakoshi A, Chumsakul O, Sato Y, Ishii T, Seykora JT: miR-4521-A novel biomarker for human lentigos. Exp Dermatol. 2024 33(6), June 2024.
12c Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol 144, May 2024.
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Selected Publications
14f Natale CA, Mercado S, Zhuang R, Aguirre-Portolés C, Olayide I, Arnatt CK, Seykora JT, Garyantes TK, Luke W, Ridky TW. : An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development. Cancer Res Commun. Mar. 2025.13d Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE.: Identification of Meibomian gland stem cell populations and mechanisms of aging. Nat Commun. Feb. 2025.
183 Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE.: Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. Cell Rep. Feb. 2025.
132 Hoffman CL, Bharathan NK, Shibata Y, Giang W, Gudjonsson JE, Seykora JT, Prouty SM, Stahley SN, Payne AS, Kowalczyk AP.: Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response. J Invest Dermatol. Feb. 2025.
1ab Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci Dec. 2024.
14d Grice EA, Brennan-Crispi D, Rodriguez N, Margolis DJ, Seykora JT, Cotsarelis G, Taylor SC, Shuda J. : Penn Academy for Skin Health (PASH): An Experiential Pipeline Program in Skin Biology and Dermatology for High-School Students. J Invest Dermatol. Oct. 2024.
184 Abbott JJ, Jiang AJ, Godse R, Ahmed S, Senft SC, Wilson MA, Cohen JV, Mitchell TC, Ogunleye TA, Higgins HW 2nd, Shin TM, Miller CJ, Roth JJ, Priore SF, Castelo-Soccio L, Elenitsas R, Seykora JT, Nathanson KL, Chu EY: Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants. JAMA Dermatol. Sept. 2024.
167 Sati S, Huang J, Kersh AE, Jones P, Ahart O, Murphy C, Prouty SM, Hedberg ML, Jain V, Gregory SG, Leung DH, Seykora JT, Rosenbach M, Leung TH: Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases. J Clin Invest. Sept. 2024.
f0 Maeno H, Suzuki-Horiuchi Y, Funakoshi A, Chumsakul O, Sato Y, Ishii T, Seykora JT: miR-4521-A novel biomarker for human lentigos. Exp Dermatol. 2024 33(6), June 2024.
12c Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol 144, May 2024.
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