Faculty

Marylyn D Ritchie, PhD

Edward Rose, M.D. and Elizabeth Kirk Rose, M.D. Professor

Department: Genetics

Graduate Group Affiliations

Contact information

A301 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104

Office: 215-573-2438

Email:
marylyn@pennmedicine.upenn.edu

Education:
BS (Biology)
University of Pittsburgh at Johnstown, 1999.
MS (Applied Statistics)
Vanderbilt University, 2002.
PhD (Statistical Genetics)
Vanderbilt University, 2004.

Links
Lab Website
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Computational Genomics
Bioinformatics
Epistasis
Pharmacogenomics
Big Data
Evolutionary Computation
Genetic Epidemiology
Statistical Genetics
Systems Genomics
Computational Biology
Translational Informatics
Cardiovascular Disease

Selected Publications

Beeche C, Kim J, Tavolinejad H, Zhao B, Sharma R, Duda J, Gee J, Dako F, Verma A, Morse C, Hou B, Shen L, Sagreiya H, Davatzikos C, Damrauer S, Ritchie MD, Rader D, Long Q, Chen T, Kahn CE, Chirinos J, Witschey WR; Penn Medicine Biobank.: A Pan-Organ Vision-Language Model for Generalizable 3D CT Representations. medRxiv Jul 2025.

Venkatesh R, Cardone KM, Bradford Y, Moore AK, Kumar R, Moore JH, Shen L, Kim D, Ritchie MD.: Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's Disease risk prediction. medRxiv Jun 2025.

Shang T, Yang S, He W, Zhai T, Li D, Hou B, Chen T, Moore JH, Ritchie MD, Shen L.: Leveraging Social Determinants of Health in Alzheimer's Research Using LLM-Augmented Literature Mining and Knowledge Graphs. AMIA Jt Summits Transl Sci Proc 2025: 491-500, Jun 2025.

Salvatore M, Zhang B, Tang H, Lu Y, Zhang D, Zhou T, Lu Y, Amaro A, Ritchie M, Chen Y.: Real-world comparative outcomes of GLP-1 RA and semaglutide prescription among individuals with type 2 diabetes. medRxiv Jun 2025.

Kumar R, Romano JD, Ritchie MD.: Network-based analyses of multiomics data in biomedicine. BioData Min 18: 37, May 2025.

Tong B, Edwards T, Yang S, Hou B, Tarzanagh DA, Urbanowicz RJ, Moore JH, Ritchie MD, Davatzikos C, Shen L.: Ensuring Fairness in Detecting Mild Cognitive Impairment with MRI. AMIA Annu Symp Proc 2024: 1119-1128, May 2025.

Safonov A, Nomakuchi TT, Chao E, Horton C, Dolinsky JS, Yussuf A, Richardson M, Speare V, Li S, Bogus ZC, Bonanni M, Raper A, Odia T, Wubbenhorst BS, Faulders E, Schuth EM, Loranger K, Zhang J, Scalise CB, ElNaggar A, Sha Y, Felker SA, Weitzel J, Kallish S, Ritchie MD; Penn Medicine BioBank; Nathanson KL, Drivas TG.: A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations. Nat Commun 16: 3121, Apr 2025.

Wang QS, Huang J, Chan L, Haste N, Olsson N, Gaun A, McAllister F, Madhireddy D, Baruch A, Cardone KM, Kumar R, Ritchie M, Susztak K, Melamud E, Baryshnikova A.: Platform-dependent effects of genetic variants on plasma APOL1. bioRxiv Apr 2025.

Yang G, González P, Moneró M, Carrasquillo K, Renta JY, Hernandez-Suarez DF, Botton MR, Melin K, Scott SA, Ruaño G, Roche-Lima A, Alarcon C, Ritchie MD, Perera MA, Duconge J.: Discovery of ancestry-specific variants associated with clopidogrel response among Caribbean Hispanics. NPJ Genom Med 10: 20, Mar 2025.

Jin J, Li B, Wang X, Yang X, Li Y, Wang R, Ye C, Shu J, Fan Z, Xue F, Ge T, Ritchie MD, Pasaniuc B, Wojcik G, Zhao B.: PennPRS: a centralized cloud computing platform for efficient polygenic risk score training in precision medicine. medRxiv Feb 2025.