Yi-Wei Chang, Ph.D.

faculty photo
Assistant Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
Department of Biochemistry and Biophysics
Perelman School of Medicine
University of Pennsylvania
913B Stellar-Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104-6059
Office: (215) 898-7789
Lab: (215) 898-1191
B.S. (Mechanical Engineering )
Chung Hua University, Taiwan, 2004.
Ph.D. (Structural Biology )
Academia Sinica & National Tsing Hua University, Taiwan, 2010.
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Description of Research Expertise

Structural biology;
Cryo-electron microscopy;
Cryo-electron tomography;
Correlative light and electron microscopy;
Cellular imaging;
Host-pathogen interaction

Selected Publications

Matthew Martinez, William David Chen, Marta Cova, Petra Andrea Molnár, Shrawan Kumar Mageswaran, Amandine Guérin, Audrey Ragan Odom John, Maryse Lebrun, Yi-Wei Chang: Rhoptry secretion system structure and priming in Plasmodium falciparum revealed using in situ cryo-electron tomography. Nature Microbiology July 2022.

Liam M Theveny*, Shrawan Kumar Mageswaran*, William David Chen, Matthew Martinez, Amandine Guérin, Yi-Wei Chang: Parasitology meets cryo-electron tomography - exciting prospects await. Trends in Parasitology Feb 2022.

Shrawan Kumar Mageswaran, Amandine Guérin*, Liam M. Theveny*, William David Chen*, Matthew Martinez, Maryse Lebrun, Boris Striepen, Yi-Wei Chang: In situ ultrastructures of two evolutionarily distant apicomplexan rhoptry secretion systems. Nature Communications 12: 4983, August 2021.

Eleonora Aquilini, Marta Mendonça Cova, Shrawan Kumar Mageswaran, Nicolas Dos Santos Pacheco, Daniela Sparvoli, Diana Marcela Penarete-Vargas, Rania Najm, Arnault Graindorge, Catherine Suarez, Marjorie Maynadier, Laurence Berry-Sterkers, Serge Urbach, Pilar Ruga Fahy, Amandine Guérin, Boris Striepen, Jean-François Dubremetz, Yi-Wei Chang, Aaron Turkewitz, Maryse Lebrun: An Alveolata secretory machinery adapted to parasite host cell invasion. Nature Microbiology 6: 425–434, January 2021.

Anke Treuner-Lange, Yi-Wei Chang, Timo Glatter, Marco Herfurth, Steffi Lindow, Georges Chreifi, Grant Jensen, Lotte Søgaard-Andersen: PilY1 and minor pilins form a complex priming the type IVa pilus in Myxococcus xanthus. Nature Communications 11(1): 5054, October 2020.

Yi-Wei Chang*, Carrie L Shaffer*, Lee A Rettberg, Debnath Ghosal, Grant J Jensen: In vivo structures of the Helicobacter pylori cag type IV secretion system. Cell Reports 23(3): 673-681, April 2018.

Yi-Wei Chang, Lee A Rettberg, Davi R Ortega, Grant J Jensen: In vivo structures of an intact type VI secretion system revealed by electron cryotomography. EMBO reports 18(7): 1090-1099, May 2017.

Yi-Wei Chang, Andreas Kjær, Davi R Ortega, Gabriela Kovacikova, John A Sutherland, Lee A Rettberg, Ronald K Taylor, Grant J Jensen: Architecture of the Vibrio cholerae toxin-coregulated pilus machine revealed by electron cryotomography. Nature Microbiology 2(4): 16269, April 2017.

Yi-Wei Chang, Lee A Rettberg, Anke Treuner-Lange, Janet Iwasa, Lotte Søgaard-Andersen, Grant J Jensen: Architecture of the type IVa pilus machine. Science 351(6278): aad2001, March 2016.

Yi-Wei Chang, Songye Chen, Elitza I Tocheva, Anke Treuner-Lange, Stephanie Löbach, Lotte Søgaard-Andersen, Grant J Jensen: Correlated cryogenic photoactivated localization microscopy and cryo-electron tomography. Nature methods 11(7): 737, July 2014.

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Last updated: 07/24/2022
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