Hamideh Parhiz, PharmD, PhD

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Research Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Stemmler Hall, Perelman School of Medicine
Philadelphia, PA 19104
PharmD (Pharmacy)
Mashhad University of Medical Sciences, Iran, 2005.
PhD (Pharmaceutical Biotechnology)
Mashhad University of Medical Sciences, Iran, 2011.
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Description of Research Expertise

Nucleic acid-based therapeutics
Targeted delivery of nanomedicine
mRNA therapeutics

Selected Publications

Tombácz I, Laczkó D, Shahnawaz H, Muramatsu H, Natesan A, Yadegari A, Papp T.E., Alameh MG, Shuvaev V, Mui B.L., Tam Y.K., Muzykantov V, Pardi N, Weissman D, Parhiz H: Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNP. Molecular Therapy June 2021.

Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek,John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez1, Hamideh Parhiz,Conrad O. Perera1, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski,Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha AlKhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, and Istvan Toth: A Global Review on Short Peptides: Frontiers and Perspectives. Molecules Jan 2021.

Marcos-Contreras O, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Suluaga-Ramirez V, Myerson JW, Hood ED, Villa C, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Brenner JS, Khoshnejad M, Madden T, Weissman D, Persidsky Y, Muzykantov VR: Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier. Proc Natl Acad Sci Page: pii: 201912012, Jan 2020.

Khoshnejad M, Brenner JS, Parhiz H, Muzykantov VR: CRISPR/Cas9-mediated genetic engineering of hybridomas for creation of antibodies that allow for site-specific conjugation. Methods Mol Biol Page: 81-93, Jul 2019.

Parhiz H, Ketcham SA, Zou G, Ghosh B, Fratz-Berilla EJ, Ashraf M, Ju T, Madhavarao CN: Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells. Appl Microbiol Biotechnol Page: doi: 10.1007/s00253-019-09889-7, Jun 2019.

Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR: PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake. J Control Release 291: 106-115, Oct 2018.

Salmasi Z, Mokhtarzadeh A, Hashemi M, Ebrahimian M, Farzad SA, Parhiz H, Ramezani M: Effective and safe in vivo gene delivery based on polyglutamic acid complexes with heterocyclic amine modified-polyethylenimine. Colloids Surf B Biointerfaces Page: 790-796, Sep 2018.

Petrochenko P, Pavurala N, Wu Y, Yee Wong S, Parhiz H, Chen K, Patil SM, Qu H, Buoniconti P, Muhammad A, Choi S, Kozak D, Ashraf M, Cruz CN, Zheng J, Xu X: Analytical Considerations for Measuring the Globule Size Distribution of Cyclosporine Ophthalmic Emulsions. Int J Pharm Page: SO378-5173(18)30607-0, Aug 2018.

Brenner JS, Pan DC, Myerson JW, Marcos-Contreras OA, Villa CH, Patel P, Hekierski H, Chatterjee S, Tao J, Parhiz H, Bhamidipati K, Uhler TG, Hood ED, Kiseleva RY, Shuvaev VS, Shuvaeva T, Khoshnejad M, Johnston I, Gregory JV, Lahann J, Wang T, Armstead WM, Mitragotri S and Muzykantov VR: Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude. Nat Comm 9(1): 2684, Jul 2018.

Parhiz H, Khoshnejad M, Myerson JW, Hood E, Patel PN, Brenner JS, Muzykantov VR: Unintended effects of drug carriers: big issues of small particles. Adv Drug Deliv Rev Page: 90-112, May 2018.

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Last updated: 11/23/2021
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