Faculty

Hamideh Parhiz, PharmD, PhD

faculty photo
Research Assistant Professor of Medicine (Infectious Diseases)
Department: Medicine
Graduate Group Affiliations

Contact information
421 Curie Boulevard
Biomedical Research Building II/III Room 1256
University of Pennsylvania Perelman School of Medicine
Philadelphia, PA 19104
Education:
PharmD (Pharmacy)
Mashhad University of Medical Sciences, Iran, 2005.
PhD (Pharmaceutical Biotechnology)
Mashhad University of Medical Sciences, Iran, 2011.
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Description of Research Expertise

Nucleic acid-based therapeutics
Nano-engineering
Targeted delivery of nanomedicine
mRNA therapeutics

Selected Publications

Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou S, Ni H, Mui BL, Tam YT, Weissman D, Rivella S, Parhiz H. : In vivo hematopoietic stem cell modification by mRNA delivery. Science 381(6656): 436-443, Jul 2023.

Breda L, Papp TE, Triebwasser M, Yadegari A, Fedorky1 MT, Tanaka N, Ni H, Weissman D, Rivella S, Parhiz H.: In Vivo Modification of Hematopoietic Stem Cells By Targeted Lipid Nanoparticles Encapsulating mRNA. Blood 140(1): 305-306, Nov 2022.

Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR.: Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). J Control Release 344(1): 50-61, Apr 2022.

2. Rurik JG, Tombácz I , Yadegari A, Fernández P.O.M, Shewale S.V, Li L , Kimura T , Soliman O.U, Papp T.E, Tam Y.K, Mui B.L, Albelda S.M, Puré E , June C.H, AghajanianH , Weissman D., Parhiz H., and Epstein J.A: CAR T cells produced in vivo to treat cardiac injury. Science 375(6576): 91-96, Jan 2022.

Tombácz I, Laczkó D, Shahnawaz H, Muramatsu H, Natesan A, Yadegari A, Papp T.E., Alameh MG, Shuvaev V, Mui B.L., Tam Y.K., Muzykantov V, Pardi N, Weissman D, Parhiz H: Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNP. Molecular Therapy 29(11): 3293–3304, Nov 2021.

Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek,John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez1, Hamideh Parhiz,Conrad O. Perera1, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski,Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha AlKhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, and Istvan Toth: A Global Review on Short Peptides: Frontiers and Perspectives. Molecules 26(2): 430, Jan 2021.

Marcos-Contreras O, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Suluaga-Ramirez V, Myerson JW, Hood ED, Villa C, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Brenner JS, Khoshnejad M, Madden T, Weissman D, Persidsky Y, Muzykantov VR: Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier. Proc Natl Acad Sci 117(7): 3405–3414, Feb 2020.

Khoshnejad M, Brenner JS, Parhiz H, Muzykantov VR: CRISPR/Cas9-mediated genetic engineering of hybridomas for creation of antibodies that allow for site-specific conjugation. Methods Mol Biol 2033(1): 81-93, Jul 2019.

Parhiz H, Ketcham SA, Zou G, Ghosh B, Fratz-Berilla EJ, Ashraf M, Ju T, Madhavarao CN: Differential effects of bioreactor process variables and purification on the human recombinant lysosomal enzyme β-glucuronidase produced from Chinese hamster ovary cells. Appl Microbiol Biotechnol 103(15): 6081-6095, Jun 2019.

Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR: PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake. J Control Release 291(1): 106-115, Dec 2018.

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Last updated: 05/21/2024
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