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Michael Guo, MD, PhD
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Assistant Professor of Neurology
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Department: Neurology
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Graduate Group Affiliations
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Contact information
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3400 Spruce Street
33 3 Gates Building
Philadelphia, PA 19104
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33 3 Gates Building
Philadelphia, PA 19104
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Education:
21 7 BS 2b (Cellular and Molecular Biology) c
3a University of Michigan--Ann Arbor, 2010.
21 8 PhD 22 (Genetics and Genomics) c
2b Harvard University, 2016.
21 7 MD c
2e University of Florida, 2018.
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Permanent link21 7 BS 2b (Cellular and Molecular Biology) c
3a University of Michigan--Ann Arbor, 2010.
21 8 PhD 22 (Genetics and Genomics) c
2b Harvard University, 2016.
21 7 MD c
2e University of Florida, 2018.
c
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1f frontotemporal dementia
19 neurodegeneration
14 neurogenetics
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16 human genetics
10 genomics
19 somatic mosaicism
1e complex trait genetics
1a Mendelian genetics
17 transcriptomics
1b Alzheimer's disease
18 neurodegeneration
e 29
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Description of Clinical Expertise
24 Alzheimer's disease1f frontotemporal dementia
19 neurodegeneration
14 neurogenetics
71
Description of Research Expertise
19 genetics16 human genetics
10 genomics
19 somatic mosaicism
1e complex trait genetics
1a Mendelian genetics
17 transcriptomics
1b Alzheimer's disease
18 neurodegeneration
e 29
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110 Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins J.: Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease. Nature Communications 16(1), January 2025.
95 Gibson AW, Elser H, Rosso M, Cornblath EJ, Fonkeu Y, Prasad S, Rothstein A, Nasrallah IM, Wolk DA, Guo MH c4 : Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab. Alzheimer's & Dementia 20(11): 8192-8197, November 2024.
18a Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik A, Elman LB, Guo M, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn CC, Tropea TF, Scherer SS, Shinohara RT, Hamilton RH, Ellis CA.: Disparities in Genetic Testing for Neurologic Disorders. Neurology 102(6): e209161, Mar 2024.
12e Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA.: The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. Biology 13(2): 93, Feb 2024.
1b9 Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurol 271(2): 733-747, Feb 2024.
1b2 Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.: Inferring compound heterozygosity from large-scale exome sequencing data. Nat Genet 56(1), Jan 2024.
1b9 Lofrano-Porto A, Pereira SA, Dauber A, Bloom JC, Fontes AN, Asimow N, de Moraes OL, Araujo PAT, Abreu AP, Guo MH, De Oliveira SF, Liu H, Lee C, Kuohung W, Coelho MS, Carroll RS, Jiang R, Kaiser UB.: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. J Clin Invest 133(23): e161701, Dec 2023.
181 Deignan JL, Gregg AR, Grody WW, Guo MH, Kearney H, Monaghan KG, Raraigh KS, Taylor J, Zepeda-Mendoza CJ, Ziats C; ACMG Board of Directors.: Updated recommendations for CFTR carrier screening: A position statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 25(8): 100867, Aug 2023.
16b Guo MH, Sama P, LaBarre BA, Lokhande H, Balibalos J, Chu C, Du X, Kheradpour P, Kim CC, Oniskey T, Snyder T, Soghoian DZ, Weiner HL, Chitnis T, Patsopoulos NA.: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets. Genome Biol 23(1): 127, Jul 2022.
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Selected Publications
1a4 Ho C-H, Dippel MA, McQuade MS, Mishra A, Pribitzer S, Nguyen LA, Hardy S, Chandok H, Chardon F, McDiarmid TA, DeBerg HA, Buckner JH, Shendure J, de Boer CG, Guo MH, Tewhey R, Ray JP: Linking candidate causal autoimmune variants to T cell networks using genetic and epigenetic screens in primary human T cells. Nature Genetics 57(10), October 2025.110 Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins J.: Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease. Nature Communications 16(1), January 2025.
95 Gibson AW, Elser H, Rosso M, Cornblath EJ, Fonkeu Y, Prasad S, Rothstein A, Nasrallah IM, Wolk DA, Guo MH c4 : Ischemic stroke associated with amyloid-related imaging abnormalities in a patient treated with lecanemab. Alzheimer's & Dementia 20(11): 8192-8197, November 2024.
18a Baldwin A, Copeland J, Azage M, Dratch L, Johnson K, Paul RA, Amado DA, Baer M, Deik A, Elman LB, Guo M, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn CC, Tropea TF, Scherer SS, Shinohara RT, Hamilton RH, Ellis CA.: Disparities in Genetic Testing for Neurologic Disorders. Neurology 102(6): e209161, Mar 2024.
12e Dratch L, Bardakjian TM, Johnson K, Babaian N, Gonzalez-Alegre P, Elman L, Quinn C, Guo MH, Scherer SS, Amado DA.: The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics. Biology 13(2): 93, Feb 2024.
1b9 Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA.: Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurol 271(2): 733-747, Feb 2024.
1b2 Guo MH, Francioli LC, Stenton SL, Goodrich JK, Watts NA, Singer-Berk M, Groopman E, Darnowsky PW, Solomonson M, Baxter S; gnomAD Project Consortium; Tiao G, Neale BM, Hirschhorn JN, Rehm HL, Daly MJ, O'Donnell-Luria A, Karczewski KJ, MacArthur DG, Samocha KE.: Inferring compound heterozygosity from large-scale exome sequencing data. Nat Genet 56(1), Jan 2024.
1b9 Lofrano-Porto A, Pereira SA, Dauber A, Bloom JC, Fontes AN, Asimow N, de Moraes OL, Araujo PAT, Abreu AP, Guo MH, De Oliveira SF, Liu H, Lee C, Kuohung W, Coelho MS, Carroll RS, Jiang R, Kaiser UB.: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity. J Clin Invest 133(23): e161701, Dec 2023.
181 Deignan JL, Gregg AR, Grody WW, Guo MH, Kearney H, Monaghan KG, Raraigh KS, Taylor J, Zepeda-Mendoza CJ, Ziats C; ACMG Board of Directors.: Updated recommendations for CFTR carrier screening: A position statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med 25(8): 100867, Aug 2023.
16b Guo MH, Sama P, LaBarre BA, Lokhande H, Balibalos J, Chu C, Du X, Kheradpour P, Kim CC, Oniskey T, Snyder T, Soghoian DZ, Weiner HL, Chitnis T, Patsopoulos NA.: Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets. Genome Biol 23(1): 127, Jul 2022.
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5b © The Trustees of the University of Pennsylvania | Site best viewed a in a supported browser. | Site Design: 57 PMACS Web Team. 3 22
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