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  • Faculty
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  • Nicolas D Plachta
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Faculty

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Nicolas D Plachta, Ph.D.

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William Richard Gordon President's Distinguished Professor in Genetics
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Department: Cell and Developmental Biology
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1f Graduate Group Affiliations 8 a
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46 Contact information
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9-123 Smilow Center for Translational Research
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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2e Office: 215-573-7462
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Email: Nicolas.Plachta@pennmedicine.upenn.edu
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18 Publications
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13 Education:
21 a B.Sc. 14 (Biology) c
63 University of Buenos Aires (Argentina) and University of Tel-Aviv (Israel), 2003.
 21 a Ph.D. 19 (Neurobiology) c
39 University of Basel, Switzerland, 2007.
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Links
a8 Search PubMed for articles
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Description of Research Expertise

2b Research Interests
e9 The Plachta lab uses live imaging technologies to study how the early mammalian embryo forms. Our goal is to reveal how cells choose their fate, shape and position in real time and in vivo to form a living mammalian organism.
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60 Key words: Live imaging, mammalian development, single-cell biology, morphogenesis
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Selected Publications

102 Zenker J, White M, Gasnier M, Alvarez Y, Lim G, Bissiere S, Biro M, Plachta N: Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation. Cell 173(3): 776-791.e17, 04 2018.

 11c Zenker J, White M, Templin R, Parton R, Thorn-Seshold O, Bissiere S, Plachta N: A microtubule-organizing center directing intracellular transport in the early mouse embryo. Science 357(6354): 925-928, Sep 2017.

 117 White M, Angiolini J, Alvarez Y, Kaur G, Zhao Z, Mocskos E, Bruno L, Bissiere S, Levi V, Plachta N: Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo. Cell 165: 75-87, 2016.

 12a Samarage C, White M, Álvarez Y, Fierro-González J, Henon Y, Jesudason E, Bissiere S, Fouras A, Plachta N: Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo. Developmental Cell 34(4): 435-47, Aug 2015.

 10a Fierro-González J, White M, Silva J, Plachta N: Cadherin-dependent filopodia control preimplantation embryo compaction. Nature Cell Biology. Nature Publishing Group, 15(12): 1424-33, Dec 2013.

 14f Kaur G, Costa M, Nefzger C, Silva J, Fierro-González J, Polo J, Bell T, Plachta N: Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy. Nature Communications Mar: 1637, 2013.

 114 Plachta N, Bollenbach T, Pease S, Fraser S, Pantazis P: Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nature Cell Biology. Nature Publishing Group, 13(2): 117-23, Feb 2011.

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