Krithika Lingappan, MD MS PhD

faculty photo
Associate Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
Kilpauk Medical College, TamilNadu Dr.MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2015.
PhD (Clinical Scientist Training Program)
Graduate School of Biomedical Sciences, Baylor College of Medicine, 2018.
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Description of Clinical Expertise

I take particular interest in evidence-based medicine (EBM) and have led several EBM initiatives. We are also interested in translational research projects related to long-term outcomes (pulmonary and cardiovascular) after preterm birth. I have leadership experience at national and regional organizations. As the leader of several national-level groups, I have created a unique niche for herself as a leader in the neonatology subspecialty with my involvement in the American Academy of Pediatrics (AAP), Section of neonatal-perinatal medicine (SONPM), NIH-funded lung basic-science research, evidence-based clinical neonatology practice, and trainee engagement and education.

Description of Research Expertise

My research focuses on reducing long-term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focuses on elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.

Selected Publications

Machut KZ, Bhombal S, Escobedo M, Kataria-Hale J, Kushnir A, Lingappan K, Oji-Mmuo CN, Owens L, Savich R, Song C, Wright R, Dammann CEL.: Call to action: gender equity in neonatology. J Perinatol Apr 2022.

Machut KZ, Kushnir A, Oji-Mmuo CN, Kataria-Hale J, Lingappan K, Kwon S, Dammann CEL.: Effect of Coronavirus Disease-2019 on the Workload of Neonatologists. J Pediatr March 2022.

Chumpitazi CE, Camp EA, Cuevas-Guaman M, Doughty C, Kancherla B, Lingappan K, Moran NE, Murray KO, Perez O, Shekerdemian LS, O'Connor TM.: Vision 2020: How Caregiving and Work Productivity Outlook Shifted for Academic Pediatric Faculty. J Womens Health (Larchmt) Feb 2022.

Kerri Z Machut, Alla Kushnir, Christiana N Oji-Mmuo, Jasmeet Kataria-Hale, Krithika Lingappan, Soyang Kwon, Christiane E L Dammann: The Effect of COVID-19 on the Workload of Neonatologists. J Pediatr. Page: doi: 10.1016, Nov 2021 Notes: epub ahead of print.

Burke R, Chu C, Zhou GD, Putluri V, Putluri N, Stading RE, Couroucli X, Lingappan K, Moorthy B.: Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells. Oxid Med Cell Longev. 2021: doi: 10.1155, Oct 2021 Notes: epub.

Lingappan K.: Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity? Am J Respir Cell Mol Biol. 65(2): 132-133, Aug 2021.

Koo J, Lingappan K, Song C.: National professional society augments career development and leadership amongst neonatal fellows and early career neonatologists. J Perinatol. July 2021.

Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K.: Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight. 6(13): e146863, July 2021.

Jain PN, Robertson M, Lasa JJ, Shekerdemian L, Guffey D, Zhang Y, Lingappan K, Checchia P, Coarfa C: Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease. Sci Rep. 11(1): 4965, Mar 2021.

Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K: Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan. Frontiers in Medicine. Frontiers in Medicine 7(1): 594137, Dec 2020.

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Last updated: 07/18/2022
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