19
1
49
2
8
1b
1d
18
30
2b
7
72
1d
2 29
1d
25
Roland L. Dunbrack
88
2b
7
72
Department: Biochemistry and Biophysics
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
4b
4
3
3
1d
4b
Institute for Cancer Reserach
1f Fox Chase Cancer Center
35 333 Cottman Avenue
Philadelphia, PA 19111
26
1f Fox Chase Cancer Center
35 333 Cottman Avenue
Philadelphia, PA 19111
30
Office: (215) 728-2434
34 Fax: (215) 728-2412
24
91
34 Fax: (215) 728-2412
24
Email:
Roland.Dunbrack@fccc.edu
12
Roland.Dunbrack@fccc.edu
18
Publications
23 a
3
2
29
4
b
1f
23 a
13
Education:
21 a Ph.D. 17 (Biophysics) c
2b Harvard University, 1993.
c
3
3
3
3
90
Permanent link21 a Ph.D. 17 (Biophysics) c
2b Harvard University, 1993.
c
2 29
21
1e
1d
24
5e
e 29
27
Description of Research Expertise
2cc The Dunbrack group concentrates on research in computational structural biology, including homology modeling, fold recognition, molecular dynamics simulations, statistical analysis of the PDB, and bioinformatics. In developing these methods, we use methods from various areas of mathematics and computer science, including Bayesian statistics and computational geometry. We place an emphasis on large-scale benchmarking of new methods and comparison with existing methods. We are interested in applying comparative modeling to important problems in various areas of biology. Areas of particular interest include DNA repair, proteases and other peptide-binding protein families, and membrane proteins.e 29
23
b4 Wang, G., Dunbrack, R.L., Jr.: PISCES: a protein sequence culling server. Bioinformatics 19: 1589-91, 2003.
dd Canutescu, A.A., Dunbrack, R.L., Jr.: Cyclic coordinate descent: a new algorithm for loop closure in protein modeling. Protein Sci 12: 963-72, 2003.
131 Yi, J., Cheng, H., Andrake, M.D., Dunbrack, R.L., Jr., Roder, H., Skalka, A.M.: Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase. J. Biol. Chem. 277: 12164-12174, 2002.
b0 Dunbrack, R.L., Jr.: Rotamer libraries in the 21st century. Curr. Opin. Struct. Biol. 12, 431-440 2002.
2c
7
1d
1f
Selected Publications
e6 Canutescu, A. A., Shelenkov, A. A., Dunbrack, R. L., Jr.: A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci. 12: 2001-2014, 2003.b4 Wang, G., Dunbrack, R.L., Jr.: PISCES: a protein sequence culling server. Bioinformatics 19: 1589-91, 2003.
dd Canutescu, A.A., Dunbrack, R.L., Jr.: Cyclic coordinate descent: a new algorithm for loop closure in protein modeling. Protein Sci 12: 963-72, 2003.
131 Yi, J., Cheng, H., Andrake, M.D., Dunbrack, R.L., Jr., Roder, H., Skalka, A.M.: Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase. J. Biol. Chem. 277: 12164-12174, 2002.
b0 Dunbrack, R.L., Jr.: Rotamer libraries in the 21st century. Curr. Opin. Struct. Biol. 12, 431-440 2002.
2c