Graduate Group in Genomics and Computational Biology

Lewis A. Chodosh, M.D., Ph.D.

faculty photo
Professor of Cancer Biology
Department: Cancer Biology

Contact information
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-1321
Fax: (215) 573-6725
Lab: (215) 898-0006
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
Harvard Medical School, 1989.
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Description of Research Expertise

Research Interests
Mechanisms of cancer development and progression.
Tumor dormancy and recurrence.
Cancer biology.
Genomics and computational biology.
Cancer genetics.
Oncogene and tumor suppressor gene function.
Genetically engineered mouse models for human cancer.
Breast cancer.
Stem cells in cancer biology.

Non-invasive imaging.

Key words: Cancer biology, cancer genetics, genomics, computational biology, oncogenes, targeted therapy, functional imaging, stem cells, development.

Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models, patient samples and computational biology to study the mechanisms by which breast cancers develop, become resistant to therapy, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology. These approaches employ molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in tumor biology using genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation.

Rotation Projects
Rotation projects are available in each of the main areas of the lab.

Lab personnel:
George Belka – Director D
Yan Chen – Research Specialist
Beth Chislock, Ph.D. – Postdoctoral Researcher
Brett Ecker - HUP Fellow
Joseph Kim – Undergraduate Student
Jun Yeop Lee – Research Specialist
Heather Martin, Ph.D. – Sr. Research Investigator
Takashi Nakamura - Graduate Student
Tien–chi Pan – Computational Biologist
Dhruv Pant – Computational Biologist
Matt Paul – Graduate Student
Fei Shen, Ph.D. – Postdoctoral Researcher
Judith Smith – Lab Manager
Chris Sterner – Research Specialist
Archit Trivedi, Ph.D. – Postdoctoral Researcher

Assistant Director, Administrative and Faculty Affairs:
Katelyn Carlin

Selected Publications

Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ and Chodosh LA: Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. Journal of Clinical Investigation 2015.

Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA: Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research 74: 7583-7598, 2014.

Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery Page: 790-803, 2014.

Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA: Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24: 30-44, 2013.

Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ and Chodosh LA: Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences USA 115: 918-27, 2013.

Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA: Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development 26: 2154-2168, 2012.

Wertheim GBW, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, Vijver MJ, Cardiff RD and Chodosh LA: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proceedings of the National Academy of Sciences USA 106(37): 15855-15860, 2009.

Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.

Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation Cell Metabolism 4: 475-490, 2006.

Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notarfrancesco K, Cardiff RD and Chodosh LA: The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.

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Last updated: 07/18/2017
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