Faculty

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Hongzhe Li (Lee), Ph.D.

Perelman Professor in Biostatistics, Epidemiology, and Informatics

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Department: Biostatistics and Epidemiology

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1f Graduate Group Affiliations 8

46 Contact information
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Department of Biostatistics and Epidemiology
3e University of Pennsylvania Perelman School of Medicine
19 215 Blockley Hall
3a 423 Guardian Drive
Philadelphia, PA 19104-6021

2e Office: 215-573-5038
32 Fax: 215-573 1050
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Email:
hongzhe@upenn.edu

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13 Education:
21 9 B.S. 24 (Mathematics/Information) c
2a Peking University, 1989.
21 a Ph.D. 17 (Statistics) c
31 University of Washington, 1995.
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Links
7e Dr. Li's Statistical Genetics and Genomics Laboratory
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5 3 3 92 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

37c My methods reserach was mostly motivated by problems in genetics and genoimics. I have worked on a variety problems in statistical genetics and genomics, including methods for family-based genetic linkage and association analysis, methods for admixture mapping, methods for genome-wide association analysis, methods for analysis of microarray time course gene expression data, high dimensional regression analysis for genomic data, methods for copy number variation analysis and methods for analysis of next generation sequence data. I have published both statistical methodological research in top statistics/biostatistics journals (JASA, AOS, AOAS, Biometrika, Biometrics, Biostatistics etc ) and in top genetics journals (AJHG, Plos Genetics, etc) and collaborative research in top scientific journals (Science, NEJM, Nature, Nature Genetics, PNAS, Developmental Cell etc).
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Selected Publications

1af Deo J, Dubin R, Ren Y, Wang J, Feldman H, Shou H, Coresh J, Grams ME, Surapaneni AL, Cohen J, Kansal M, Rahman M, Dobre M, He J, Kelly T, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H, Ganz P: Proteomic Assessment of the Risk of Secondary Cardiovascular Events among Individuals with CKD. Journal of the American Society of Nephrology 36(2): 231-241, Feb 2025.

f1 Yan B, Nam Y, Li L, Deek R, Li H, Ma S : Recent advances in deep learning and language models for studying the microbiome. Frontiers in Genetics(15), 1494474, Jan 2025.

153 Benitez AJ, Tanes C, Friedman ES, Zackular JP, Ford E, Gerber JS, DeRusso PA, Kelly A, Li H, Elovitz MA, Wu GD, Zemel B, Bittinger K: Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants. Microbiome 13(1): 21, Jan 2025.

13b Bonhomme B, Nandi N, Berera S, Lee H, Leung G, Chung San Tse, Weiss A, Nessel L, Ren Y, Li H, Aberra F, Lewis JD : Greater Fatigue and Reduced Neurocognitive Speed With Symptomatic Crohn's Disease. Crohns Colitis 360 7(1): otae069, Dec 2024.

f5 Liu S, Adams SE, Zheng H, Ehnot J, Jung SK, Greer J, Menna T, Purton LE, Lee H, Kurre P: Dynamic Tracking of Native Precursors in Adult Mice. Elife(13), RP97504, Dec 2024.

106 Wang J, Li S and Li H : A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance. Journal of the American Statistical Association 119(548): 2585-2597, Nov 2024.

cb Mirda D, Dungan D,Ren Y, Li H, Katona BW : Colorectal neoplasia detection rates in Lynch syndrome. Cancers 16(23): 4021, Nov 2024.

166 Strauss Starling A, Ren Y, Li H, Spergel JM, Muir AB, Lynch KL, Liacouras CA, Falk GW: Reducing Eosinophil Counts in Eosinophilic Esophagitis in Children Is Associated With Reduction in Later Stricture Development. The American Journal of Gastroenterology 119(10): 2002-2009. Oct 2024.

1c0 Kumar A, Gwalani P, Iyer PG, Wang KK, Falk GW, Ginsberg GG, Lightdale CJ, Del Portillo A, Lagana SM, Li Y, Li H, Genkinger J, Jin Z, Rustgi AK, Wang TC, Wang HH, Quante M, Abrams JA: Shifts in Serum Bile Acid Profiles Associated With Barrett's Esophagus and Stages of Progression to Esophageal Adenocarcinoma. Clinical and Translational Gastroenterology 15(10): e1, Oct 2024.

102 Tu V, Ren Y, Tanes C, Mukhopadhyay S, Daniel SG, Li H, Bittinger K.: A quantitative approach to measure and predict microbiome response to antibiotics. mSphere 9(9): e0048824, Sep 2024.

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26 Last updated: 10/22/2025
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