Faculty

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Marylyn D Ritchie, PhD

Adjunct Professor of Genetics

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Department: Genetics

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1f Graduate Group Affiliations 8

46 Contact information
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A301 Richards Building
35 3700 Hamilton Walk
Philadelphia, PA 19104

2e Office: 215-573-2438
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Email:
marylyn@pennmedicine.upenn.edu

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13 Education:
21 7 BS 14 (Biology) c
3e University of Pittsburgh at Johnstown, 1999.
21 7 MS 1f (Applied Statistics) c
2e Vanderbilt University, 2002.
21 8 PhD 21 (Statistical Genetics) c
2e Vanderbilt University, 2004.
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Links
5a Lab website
4b Lab Website
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5 3 3 92 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

28 Computational Genomics
16 Bioinformatics
12 Epistasis
18 Pharmacogenomics
10 Big Data
20 Evolutionary Computation
1d Genetic Epidemiology
1d Statistical Genetics
19 Systems Genomics
1e Computational Biology
22 Translational Informatics
1d Cardiovascular Disease
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Selected Publications

194 Beeche C, Kim J, Tavolinejad H, Zhao B, Sharma R, Duda J, Gee J, Dako F, Verma A, Morse C, Hou B, Shen L, Sagreiya H, Davatzikos C, Damrauer S, Ritchie MD, Rader D, Long Q, Chen T, Kahn CE, Chirinos J, Witschey WR; Penn Medicine Biobank.: A Pan-Organ Vision-Language Model for Generalizable 3D CT Representations. medRxiv Jul 2025.

128 Venkatesh R, Cardone KM, Bradford Y, Moore AK, Kumar R, Moore JH, Shen L, Kim D, Ritchie MD.: Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's Disease risk prediction. medRxiv Jun 2025.

151 Shang T, Yang S, He W, Zhai T, Li D, Hou B, Chen T, Moore JH, Ritchie MD, Shen L.: Leveraging Social Determinants of Health in Alzheimer's Research Using LLM-Augmented Literature Mining and Knowledge Graphs. AMIA Jt Summits Transl Sci Proc 2025: 491-500, Jun 2025.

123 Salvatore M, Zhang B, Tang H, Lu Y, Zhang D, Zhou T, Lu Y, Amaro A, Ritchie M, Chen Y.: Real-world comparative outcomes of GLP-1 RA and semaglutide prescription among individuals with type 2 diabetes. medRxiv Jun 2025.

c1 Kumar R, Romano JD, Ritchie MD.: Network-based analyses of multiomics data in biomedicine. BioData Min 18: 37, May 2025.

126 Tong B, Edwards T, Yang S, Hou B, Tarzanagh DA, Urbanowicz RJ, Moore JH, Ritchie MD, Davatzikos C, Shen L.: Ensuring Fairness in Detecting Mild Cognitive Impairment with MRI. AMIA Annu Symp Proc 2024: 1119-1128, May 2025.

219 Safonov A, Nomakuchi TT, Chao E, Horton C, Dolinsky JS, Yussuf A, Richardson M, Speare V, Li S, Bogus ZC, Bonanni M, Raper A, Odia T, Wubbenhorst BS, Faulders E, Schuth EM, Loranger K, Zhang J, Scalise CB, ElNaggar A, Sha Y, Felker SA, Weitzel J, Kallish S, Ritchie MD; Penn Medicine BioBank; Nathanson KL, Drivas TG.: A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations. Nat Commun 16: 3121, Apr 2025.

13c Wang QS, Huang J, Chan L, Haste N, Olsson N, Gaun A, McAllister F, Madhireddy D, Baruch A, Cardone KM, Kumar R, Ritchie M, Susztak K, Melamud E, Baryshnikova A.: Platform-dependent effects of genetic variants on plasma APOL1. bioRxiv Apr 2025.

183 Yang G, González P, Moneró M, Carrasquillo K, Renta JY, Hernandez-Suarez DF, Botton MR, Melin K, Scott SA, Ruaño G, Roche-Lima A, Alarcon C, Ritchie MD, Perera MA, Duconge J.: Discovery of ancestry-specific variants associated with clopidogrel response among Caribbean Hispanics. NPJ Genom Med 10: 20, Mar 2025.

144 Jin J, Li B, Wang X, Yang X, Li Y, Wang R, Ye C, Shu J, Fan Z, Xue F, Ge T, Ritchie MD, Pasaniuc B, Wojcik G, Zhao B.: PennPRS: a centralized cloud computing platform for efficient polygenic risk score training in precision medicine. medRxiv Feb 2025.

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26 Last updated: 07/21/2025
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