Faculty

Brielin Chase Brown, PhD.

Assistant Professor of Biostatistics and Epidemiology

Department: Biostatistics and Epidemiology

Graduate Group Affiliations

Contact information

421 Blockley Hall
423 Guardian Drive
University of Pennsylvania
Philadelphia, PA 19104

Email:
brielin.brown@pennmedicine.upenn.edu

Education:
B.A. (Computer Science)
University of Virginia, 2011.
Ph.D. (Computer Science)
University of California, Berkeley, 2016.

Links
Github
LinkedIn
Group website

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Silva Kasela, Francois Arguet, Sarah Kim-Hellmuth, Brielin C Brown, Daniel C Nachun, Russell P Tracy, Peter Durda, Yongmei Liu, Kent D Taylor, W Craig Johnson, David Van Den Berg, Stacey Gabriel, Namrata Gupta, Joshua D Smith, Thomas W Blackwell, Jerome I Rotter, Kristin G Ardlie, Ani Manichaikul, Stephen S Rich, R Graham Barr, Tuuli Lappalainen: Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects. American Journal of Human Genetics 111(1): 133-149, January 2024 Notes: DOI: 10.1016/J.AJHG.2023.11.013.

B.C. Brown, J.A. Morris, T. Lappalainen, D.A. Knowles : Large-scale causal discovery using interventional data sheds light on the regulatory network architecture of blood traits. bioRxiv October 2023 Notes: doi: 10.1101/2023.10.13.562293.

B.C. Brown, C. Wang, S. Kasela, F. Aguet, D.C. Nachun, K.D. Taylor, R.P. Tracy, P. Durda, Y. Liu, W.C. Johnson, D. Van Den Berg, N. Gupta, S. Gabriel, J.D. Smith, R. Gerzsten, C. Clish, Q. Wong, G. Papanicolau, T.W. Blackwell, J.I. Rotter, S.S. Rich, R.G Barr, K.G. Ardlie, D.A. Knowles, and T. Lappalainen : Multiset correlation and factor analysis enables exploratory analysis of multi-omic data. Cell Genomics 3(8): 100359, July 2023.

B.C. Brown and D. A. Knowles : Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization. The American Journal of Human Genetics 108(12): 2319–2335, December 2021.

B.C. Brown and D. A. Knowles : Phenome-scale causal network discovery with bidirectional mediated Mendelian randomization. bioRxiv June 2020 Notes: doi: https://doi.org/10.1101/2020.06.18.160176.

M. Lam, C. Chen, Z. Li, A.R. Martin, J. Bryois, X. Ma, H. Gaspar, M. Ikeda, B. Benyamin, B.C. Brown, R. Liu, W. Zhou, L. Guan, Y. Kamatani, S. Kim, M. Kubo, A.A.A.A. Kusumawardhani, C. Liu, H. Ma, S. Periyasamy, A. Takahashi, Z. Xu, H. Yu, F. Zhu, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Indonesia Schizophrenia Consortium, Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), W.J. Chen, S. Faraone, S.J. Glatt, L. He, S.E. Hyman, H. Hwu, S.A. McCarroll, B.M. Neale, P. Sklar, D.B. Wildenauer, X. Yu, D. Zhang, B.J. Mowry, J. Lee, P. Holmans, S. Xu, P.F. Sullivan, S. Ripke, M.C. O’Donovan, M.J. Daly, S. Qin, P. Sham, N. Iwata, K.S. Hong, S.G. Schwab, W. Yue, M. Tsuang, J. Liu, X. Ma, R.S. Kahn, Y. Shi and H. Huang: Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics 51: 1670–1678, November 2019.

K.J. Galinsky, Y.A. Reshef, H.K. Finucane, P. Loh, N. Zaitlen, N.J. Patterson, B.C. Brown, and A.L. Price: Estimating cross-population genetic correlations of causal effect sizes. Genetic Epidemiology 43(2): 180-188, March 2019.

B.C. Brown, N.L. Bray and L. Pachter : Expression Reflects Population Structure. PLOS Genetics 14 (12): e100784, December 2018.

B.C. Brown, A.L. Price, N.A. Patsopolous and N. Zaitlen : Local joint testing improves power and identifies both missing and spurious heritability in association studies. Genetics 203(3): 1105-16, July 2016.

B.C. Brown, AGEN-T2D, C. Ye, A.L. Price and N. Zaitlen : Transethnic genetic correlation estimates from summary statistics. The American Journal of Human Genetics 99(1): 76–88, July 2016.