Faculty

Haochang Shou, Ph.D.

Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania

Department: Biostatistics and Epidemiology

Graduate Group Affiliations

Graduate Group in Epidemiology and Biostatistics

Contact information

Department of Biostatistics, Epidemiology and Informatics
University of Pennsylvania School of Medicine
D006 Richards Medical Research Laboratories
3700 Hamilton Walk
Philadelphia, PA 19104

Office: 215-573-6534

Email:
hshou@pennmedicine.upenn.edu

Education:
B.Sc. (Statistics)
Peking University, China, 2009.
Ph.D. (Biostatistics)
Johns Hopkins Bloomberg School of Public Health, 2014.

Links
The Penn Statistics in Imaging and Visualization Center (PennSIVE)

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Dr. Shou’s methodological research mainly focuses on functional data analysis with complex structures. She is particularly interested in novel statistical modeling and estimation techniques for multimodal functional and longitudinal measurements, including neuroimaging and human activity data. Her collaborations span brain disorder studies, mental health, and biomarker evaluation for chronic kidney disease.

Selected Publications

Chen AA, Weinstein SM, Adebimpe A, Gur RC, Gur RE, Merikangas KR, Satterthwaite TD, Shinohara RT*, Shou H*: Similarity-based multimodal regression. Biostatistics 25(4): 1122-1139, Oct 2024 Notes: doi: 10.1093/biostatistics/kxad033. *co-senior authorship.

Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga AW, O'Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Nick Bryan R, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C.: Brain aging patterns in a large and diverse cohort of 49,482 individuals. Nat Med 30(10): 3015-3026, Oct 2024 Notes: doi: 10.1038/s41591-024-03144-x.

Wen J, Yang Z, Nasrallah IM, Cui Y, Erus G, Srinivasan D, Abdulkadir A, Mamourian E, Hwang G, Singh A, Bergman M, Bao J, Varol E, Zhou Z, Boquet-Pujadas A, Chen J, Toga AW, Saykin AJ, Hohman TJ, Thompson PM, Villeneuve S, Gollub R, Sotiras A, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Benzinger TL, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Ferrucci L, Fan Y, Habes M, Wolk D, Shen L, Shou H, Davatzikos C.: Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum. Transl Psychiatry 14(1): 420, Oct 2024 Notes: doi: 10.1038/s41398-024-03121-5.

Deo R, Dubin RF, Ren Y, Wang J, Feldman H, Shou H, Coresh J, Grams ME, Surapaneni AL, Cohen JB, Kansal M, Rahman M, Dobre M, He J, Kelly T, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H, Ganz P.: Proteomic Assessment of the Risk of Secondary Cardiovascular Events among Individuals with CKD. J Am Soc Nephrol Sep 2024 Notes: doi: 10.1681/ASN.0000000502. Online ahead of print.

Hu F, Lucas A, Chen AA, Coleman K, Horng H, Ng RWS, Tustison NJ, Davis KA, Shou H, Li M, Shinohara RT; Alzheimer's Disease Neuroimaging Initiative.: DeepComBat: A statistically motivated, hyperparameter-robust, deep learning approach to harmonization of neuroimaging data. Hum Brain Mapp 45(11): e26708, Aug 2024 Notes: doi: 10.1002/hbm.26708.

Chen AA, Clark K, Dewey BE, DuVal A, Pellegrini N, Nair G, Jalkh Y, Khalil S, Zurawski J, Calabresi PA, Reich DS, Bakshi R, Shou H*, Shinohara RT*; Alzheimer’s Disease Neuroimaging Initiative, and North American Imaging in Multiple Sclerosis Cooperative.: PARE: A framework for removal of confounding effects from any distance-based dimension reduction method. PLoS Comput Biol 20(7): e1012241, Jul 2024 Notes: doi: 10.1371/journal.pcbi.1012241. *co-senior authorship.

Skampardoni I, Nasrallah IM, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan ST, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Yaffe K, Völzke H, Ferrucci L, Benzinger TLS, Ezzati A, Shinohara RT, Fan Y, Resnick SM, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C: Genetic and clinical correlates of AI-based brain aging patterns in cognitively unimpaired individuals. JAMA Psychiatry 81(5): 456-467, May 2024 Notes: doi: 10.1001/jamapsychiatry.2023.5599.

Kawut SM, Feng R, Ellenberg SS, Zamanian R, Bull T, Chakinala M, Mathai SC, Hemnes A, Lin G, Doyle M, Andrew R, MacLean M, Stasinopoulos I, Austin E, DeMichele A, Shou H, Minhas J, Song N, Moutchia J, Ventetuolo CE.: Pulmonary hypertension and anastrozole (PHANTOM): A randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med May 2024 Notes: doi: 10.1164/rccm.202402-0371OC.

Mu S, Bao J, Xu H, Shivakumar M, Yang S, Ning X, Kim D, Davatzikos C, Shou H, Shen L; ADNI.: Multivariate mediation analysis with voxel-based morphometry revealed the neurodegeneration pathways from genetic variants to Alzheimer's Disease. AMIA Jt Summits Transl Sci Proc 2024: 344-353, May 2024.

Radhakrishnan H, Zhao C, Sydnor VJ, Baller EB, Cook PA, Fair DA, Giesbrecht B, Larsen B, Murtha K, Roalf DR, Rush-Goebel S, Shinohara RT, Shou H, Tisdall MD, Vettel JM, Grafton ST, Cieslak M, Satterthwaite TD.: A practical evaluation of measures derived from compressed sensing diffusion spectrum imaging. Hum Brain Mapp 45(5): e26580, Apr 2024 Notes: doi: 10.1002/hbm.26580.