Faculty

Gregory P Bisson, MD, MSCE

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Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
832 Blockley Hall
423 Guardian Drive
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania
Philadelphia, PA 19104-6021
Office: 215-573-5811
Fax: 215-573-5315
Education:
BA (Japanese)
University of Wisconsin-Madison, 1992.
MD
University of Minnesota School of Medicine, 1997.
MSCE (Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2006.
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Description of Research Expertise

My research is dedicated to improving treatment outcomes of patients with HIV and tuberculosis (TB) and other AIDS-associated opportunistic infections. Current research projects are evaluating the relationship between very early virologic and immunologic response to antiretroviral therapy and clinical outcomes in adults with HIV/TB. Many patients with advanced HIV die soon after antiretroviral therapy initiation, and our research group focuses on trying to understand the pathophysiologic and social mechanisms underlying these early deaths. In addition, we are pursuing translational projects evaluating novel host-directed therapies for treatment of drug resistant TB.

Selected Publications

Matoga M, Bisson GP, Gupta A, Miyahara S, Sun X, Manabe YC, Kumwenda J, Malawi B, Kanyama C, Nyirenda M, Ngongondo M, Mbewe A, Moi DL, Wallis C, Mugerwa H, Hosseinipour MC, on behalf of the Adult AIDS Clinical Trials Group A5274 (REMEMBER) Study Team: Urine LAM Testing in Advanced HIV-Infected Adults in a Trial of Empiric TB Therapy Clin Infect Disis 73(4): e870-e877, Aug 2021.

Krishnan S, Queiroz A, Guptal A, Gupte N, Bisson GP, Kumwenda J, Naidoo K, Mohapi L, Mave V, Mngqibisa R, Lama JR, Hosseinipour MC, Andrade BB, and Karakousis PC, on behalf of the ACTG A5274 REMEMBER NWCS 414 Study Team : Integrative Multi-Omics Reveals Serum Markers of Tuberculosis in Advanced HIV. Frontiers in Immunology Jun 2021.

Auld SC, Kornfeld H, Maenetje P, Mlotshwa M, Chase W, Vangu MT, Torigian, DA, Wallis RS, Churchyard G, Bisson GP: Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis. BMC Pulmonary Medicine 21(1), Jan 2021.

Opollo V, Sun X, Lando R, Miyahara S, Torres TS, Hosseinpour MC, Bisson GP, Kumwenda J, Gupta A, Nyirenda M, Katendey K, Suryavanshi N, Beulah F, Shah NS, on behalf of the A5274 study team : The effect of TB treatment on health-related quality of life for people with advanced HIV Int J Tuberc Lung Dis 24(9): 910-915, Sept 2020.

Bisson GP, Bastos M, Campbell JR, Bang D, Brust JC, Isaakadis P, Lange C, Menzies D, Migliori GB, Pape JW, Palmero D, Baghei P, Tabarsi P, Viiklepp P, Vilbrun S, Walsh J and Marks SM: Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis. Lancet 396(10248): 402-411, Aug 2020.

Zentner I, Back HM, Kagan L, Nagajyothi J, Subbian S, Pasipanodya J, Srivastava S, Gumbo T, Bisson GP, Vinnard C.: Redox imbalance and oxidative DNA damage during isoniazid treatment: A clinical and translational pharmacokinetic study. Frontiers in Pharmacology July 2020.

Auld SC, Maenetje P, Ravimohan S, Weissman D, Ncube I, Mlotshawa M, Ratsela N, Chase W, Vangu MDI-T, Wallis R, Churchyard G, Kornfeld H, Bisson GP: Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis 70(8): 1750-1753, Apr 2020.

Mehta K, Ravimohan S, Pasipanodya JG, Srivastava S, Modongo C, Zetola NM, Weissman D, Ivaturi V, Gumbo T, Bisson GP, Vinnard C: Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study. J Antimicrob Chemother Page: pii: dkz265, Jul 2019.

Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu M-D-T, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP: Lung injury on antiretroviral therapy in adults with HIV/TB. Clin Infect Dis Page: pii: ciz560, Jun 2019.

Torgersen J, Bellamy SL, Ratshaa B, Han X, Mosepele M, Zuppa AF, Vujkovic M, Steenhoff AP, Bisson GP, Gross R: Impact of Efavirenz Metabolism on Loss to Care in Older HIV+ Africans. Eur J Drug Metab Pharmacokinet 44(2): 179-187, Apr 2019.

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Last updated: 12/04/2021
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