Hongzhe Li (Lee), Ph.D.

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Perelman Professor in Biostatistics, Epidemiology, and Informatics
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics and Epidemiology
University of Pennsylvania Perelman School of Medicine
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-5038
Fax: 215-573 1050
B.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
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Description of Research Expertise

My methods reserach was mostly motivated by problems in genetics and genoimics. I have worked on a variety problems in statistical genetics and genomics, including methods for family-based genetic linkage and association analysis, methods for admixture mapping, methods for genome-wide association analysis, methods for analysis of microarray time course gene expression data, high dimensional regression analysis for genomic data, methods for copy number variation analysis and methods for analysis of next generation sequence data. I have published both statistical methodological research in top statistics/biostatistics journals (JASA, AOS, AOAS, Biometrika, Biometrics, Biostatistics etc ) and in top genetics journals (AJHG, Plos Genetics, etc) and collaborative research in top scientific journals (Science, NEJM, Nature, Nature Genetics, PNAS, Developmental Cell etc).

Selected Publications

Rhee, R; Lu, J; Bittinger, K; Sreih, A; Lee, J; Mattei, L; Sreih, A; Chou, S; Miner, J; Cohen, N; Kelly, B; Li, H; Grayson, P; Collman, R; Merkel, P: Dynamic Changes in the Nasal Microbiome in Patients with Granulomatosis with Polyangiitis. Arthritis & Rheumatology 73(9): 1703-1712, Sep 2021 Notes: doi: 10.1002/art.41723. Epub 2021 Jul 31.

Wilson, N; Zhao, N; Zhan, X; Koh, H; Fu, W; Chen, J; Li, H; Wu, M; Plantinga, A: MiRKAT: Kernel Machine Regression-Based Global Association Tests for the Microbiome. Bioinformatics 37(11): 1595-1597, Jul 2021 Notes: doi: 10.1093/bioinformatics/btaa951.

Ma, J; Bowen, X; Yan, C; Xin, H; Bennett, K; Tong, C; Chiying, A; Hojnacki, T; Feng, Z; Sunbin, D; Sunbin, L; Xie, G; Wu, Y; Ren, Y; Katona, B; Li, H; Naji, A; Xianxin, H: Menin-Regulated Pbk Controls High Fat Diet-Induced Compensatory Beta Cell Proliferation. EMBO Molecular Medicine 13(5): e13524, May 2021 Notes: doi: 10.15252/emmm.202013524. Epub 2021 Apr 6.

Ma, J; Xing, B; Cao, Y; He, X; Bennett, K; Tong, C; An, C; Hojnacki, T; Feng, Z; Deng, S; Ling, S; Xie, G; Wu, Y; Ren, Y; Yu, M; Katona, B; Li, H; Naji, A; Hua, X: Menin-Regulated Pbk Controls High Fat Diet-Induced Compensatory Beta Cell Proliferation. EMBO Molecular Medicine 13(5), Apr 2021 Notes: doi: 10.15252/emmm.202013524. Online ahead of print.

Raj, D; Sohn, M; Charytan, D; Himmelfarb, J; Ikizler, T. Alp; Mehrotra, R; Ramezani, A; Regunathan-Shenk, R; Hsu, J; Landis, J; Li, H; Kimmel, P; Kliger, A; Dember, L; for the Hemodialysis Novel Therapies Consortium: The Microbiome and p-Inulin in Hemodialysis: A Feasibility Study. Kidney360 2(3): 445-455, Mar 2021 Notes: DOI: https://doi.org/10.34067/KID.0006132020.

Tanes, C; Bittinger, K; Gao, Y; Friedman, E; Nessel, L; Paladhi, U; Chau, L; Panfen, E; Fischbach, M; Braun, J; Xavier, R; Clish, C; Li, H; Bushman, F; Lewis, J; Wu, G: Role of Dietary Fiber in the Recovery of the Human Gut Microbiome and its Metabolome. Cell Host & Microbe 29(3): 394-407.e5, Mar 2021 Notes: doi: 10.1016/j.chom.2020.12.012. Epub 2021 Jan 12.

Gershuni, V; Li, Y; Elovitz, M; Li, H; Wu, G; Compher, C: Maternal Gut Microbiota Reflecting Poor Diet Quality is Associated with Spontaneous Preterm Birth in a Prospective Cohort Study. American Journal of Clinical Nutrition 113(3): 602-611, Mar 2021 Notes: doi: 10.1093/ajcn/nqaa361.

Deek, R; Li, H: A Zero-Inflated Latent Dirichlet Allocation Model for Microbiome Studies. Fronters in Genetics 11:602594, Jan 2021 Notes: doi: 10.3389/fgene.2020.602594. eCollection 2020.

Smith, S; Ogawa, S; Chau, L; Whelan, K; Hamilton, K; Chen, J; Tan, L; Chen, E; Keilbaugh, S; Fogt, F; Bewtra, M; Braun, J; Xavier, R; Clish, C; Slaff, B; Wiljie, A; Bushman, F; Lewis, J; Li, H; Master, S; Bennett, M; Nakagawa, H; Wu, G : Mitochondrial Dysfunction in Inflammatory Bowel Disease Alters Intestinal Epithelial Metabolism of Hepatic Acylcarnitines. Journal of Clinical Investigation 131(1): e133371, Jan 2021 Notes: doi: 10.1172/JCI133371.

Liu, M; Li, H: Estimation of Heterogeneous Restricted Mean Survival Time Using Random Forest. Fronters in Genetics 11:587378, Jan 2021 Notes: doi: 10.3389/fgene.2020.587378. eCollection 2020.

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Last updated: 10/26/2021
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