Michael O. Harhay, PhD

faculty photo
Assistant Professor of Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
304 Blockley Hall
Philadelphia, PA 19104
B.S. (Neuroscience and Philosophy)
Muhlenberg College, 2005.
M.Be (Bioethics)
University of Pennsylvania , 2006.
M.P.H. (Public Health)
University of Pennsylvania , 2009.
M.A. (Demography)
University of Pennsylvania , 2010.
M.A. (Statistics)
University of Pennsylvania, 2015.
Ph.D. (Epidemiology)
University of Pennsylvania, 2016.
Permanent link
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Description of Research Expertise

Clinical Epidemiology, Medical Statistics, Evidence Synthesis

Selected Publications

Zampieri FG, Casey JD, Shankar-Hari M, Harrell FE Jr, Harhay MO: Using Bayesian methods to augment the interpretation of critical care trials. an overview of theory and example reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial. American Journal of Respiratory and Critical Care Medicine 203(5): 543-552, Mar 2021.

Harhay MO, Casey JD, Clement M, Collins SP, Gayat É, Gong MN, Jaber S, Laterre PF, Marshall JC, Matthay MA, Monroe RE, Rice TW, Rubin E, Self WH, Mebazaa A: Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Intensive Care Medicine 46(5): 930-942, May 2020.

Haines KJ, Hibbert E, McPeake J, Anderson BJ, Bienvenu OJ, Andrews A, Brummel NE, Ferrante LE, Hopkins RO, Hough CL, Jackson J, Mikkelsen ME, Leggett N, Montgomery-Yates A, Needham DM, Sevin CM, Skidmore B, Still M, van Smeden M, Collins GS, Harhay MO.: Prediction models for physical, cognitive, and mental health impairments after critical illness: a systematic review and critical appraisal. Critical Care Medicine 48(12): 1871-1880, Dec 2020 Notes: doi: 10.1097/CCM.0000000000004659.

Kim J, Troxel AB, Halpern SD, Volpp KG, Kahan BC, Morris TP, Harhay MO: Analysis of multicenter clinical trials with very low event rates. Trials 21(1): 917. doi: 10.1186/s13063-020-04801-5, Nov 2020.

Wang W, Small DS, Harhay MO: Semiparametric estimation of the attributable fraction when there are interactions under monotonicity constraints. BMC Medical Research Methodology 20(1): 236, Sep 2020 Notes: doi: 10.1186/s12874-020-01118-4.

Harhay MO, Donaldson GC: Guidance on statistical reporting to help improve your chances of a favorable statistical review. American Journal of Respiratory and Critical Care Medicine 201(9): 1035-1038, May 2020.

Harhay MO, Ratcliffe SJ, Small DS, Suttner LH, Crowther MJ, Halpern SD: Measuring and analyzing length of stay in critical care trials. Medical Care 57(9): e53–e59, Sep 2019.

Harhay MO, Porcher R, Cantu E, Crowther MJ, Christie JD, Thabut G, Donaldson GC: An alternative approach for the analysis of time-to-event and survival outcomes in pulmonary medicine. American Journal of Respiratory and Critical Care Medicine 198(5): 684-687, Sep 2018.

Harhay MO, Porcher R, Thabut G, Crowther MJ, DiSanto T, Rubin S, Penfil Z, Bing Z, Christie JD, Diamond JM, Cantu E: Donor lung sequence number and survival after lung transplantation in the United States. Annals of the American Thoracic Society 16(3): 313-320, Mar 2019.

Halpern SD, Harhay MO, Saulsgiver K, Brophy C, Troxel AB, Volpp KG: A pragmatic trial of e-cigarettes, incentives, and drugs for smoking cessation. New England Journal of Medicine 378(24): 2302-2310, Jun 2018.

Harhay MO, Ratcliffe SJ, Halpern SD: Measurement error due to patient flow in estimates of intensive care unit length of stay. American Journal of Epidemiology 186(12): 1389-1395, Dec 2017.

Harhay MO, Halpern SD: End-of-life care among immigrants: disparities or differences in preferences? JAMA 318(15): 1448-1449, Oct 2017.

Harhay MO, Fawzi MCS, Jeanneret S, Ndayisaba D, Kibaalya W, Harrison EA, Small DS: An assessment of the Francois-Xavier Bagnoud poverty alleviation program in Rwanda and Uganda. International Journal of Public Health 62(2): 241-252, Mar 2017.

Kahan BC, Harhay MO: Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs. Journal of Clinical Epidemiology 68(12): 1504-11, Dec 2015 Notes: Co-first author.

Halpern SD, French B, Small DS, Saulsgiver K, Harhay MO, Audrain-McGovern J, Loewenstein G, Brennan TA, Asch DA, Volpp KG: Randomized trial of four financial-incentive programs for smoking cessation. New England Journal of Medicine 372(22): 2108-17, May 2015.

Harhay MO, Wagner J, Ratcliffe SJ, Bronheim RS, Gopal A, Green S, Cooney E, Mikklesen ME, Kerlin MP, Small DS, Halpern SD: Outcomes and statistical power in adult critical care randomized trials. American Journal of Respiratory and Critical Care Medicine 189(12): 1469-78, Jun 2014.

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Last updated: 11/23/2021
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