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Rui Feng, Ph.D.
9dAssociate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
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Department: Biostatistics and Epidemiology
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Contact information
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423 Guardian Drive
19 209 Blockley Hall
41 Department of Biostatistics, Epidemiology and Informatics
59 University of Pennsylvania Perelman School of Medicine
Philadelphia, PA 19104
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19 209 Blockley Hall
41 Department of Biostatistics, Epidemiology and Informatics
59 University of Pennsylvania Perelman School of Medicine
Philadelphia, PA 19104
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Office: 215-746-4473
32 Fax: 215-573-4865
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Email:
ruifeng@upenn.edu
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ruifeng@upenn.edu
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Publications
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Education:
21 9 B.S. 18 (Mathematics) c
46 University of Science and Technology of China, 1999.
21 9 M.S. 17 (Statistics) c
35 The Johns Hopkins University, 2001.
21 a Ph.D. 1a (Biostatistics) c
28 Yale University, 2005.
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Permanent link21 9 B.S. 18 (Mathematics) c
46 University of Science and Technology of China, 1999.
21 9 M.S. 17 (Statistics) c
35 The Johns Hopkins University, 2001.
21 a Ph.D. 1a (Biostatistics) c
28 Yale University, 2005.
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1bb Dr. Feng’s current research focuses on exploring and improving the potential of deep learning methodologies, for structured input variables in biomedical research. Her recent development of the peel learning model, structure-guided transformer models, and redefined interpretability, contribute to ongoing efforts to address pragmatic challenges such as limited sample sizes and the underutilization of correlations among predictors.
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33 Past Contributions in Genetics and Genomics
1f2 In the past, Dr. Feng has been devoted to statistical modeling for complex and high-dimensional genetic and genomic studies. Her early contributions include innovative models for testing familial segregation, gene mapping, and adjustment for sampling bias in ordinal traits. Later, she developed multiple haplotype-based methods for joint SNP-CNV calling, analysis of parent-of-origin effects in SNP and sequence data, instrumental variable selection, and high-dimensional causal inference.
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33 Leadership in Multi-Center Clinical Studies
3a4 Dr. Feng has directed the design and data management of several high-impact multi-center clinical studies, including a pediatric study of the respiratory outcomes of extremely preterm infants (PROP, 2010-2016), a trial of novel Peg-IFN-a2b treatment in HIV patients (BEAT-HIV, 2013-2018), a multicenter pragmatic trial to evaluate the surgery outcomes of hip-fracture patients receiving spinal vs. general anesthesia (REGAIN, 2015-2021), a phase-II Lenabasum treatment trial in dermatomyositis (Lenabasum, 2015-2018), a phase-II trial to determine the effectiveness of anastrozole on pulmonary arterial hypertension (PHANTOM, 2016-2022), and a stepped-wedge clustered randomized trial of nudges to reduce benzodiazepine use in senior surgical patients (DROP-BENZO, 2022-24). These projects have set high standards in data quality and have been instrumental in producing high-impact publications in top-tier medical journals.
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2a Mentorship and Academic Leadership
180 Dr. Feng has mentored over 20 medical fellows, numerous Master’s and Ph.D. students, and 4 postdoctoral fellows, guiding them through successful research careers. Since joining Penn Biostatistics in August 2009—following her faculty appointment at the University of Alabama at Birmingham—she has continued to foster a rich environment for academic growth and innovation.
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6e Dr. Feng currently serves as the Treasurer of the International Chinese Statistical Association (ICSA).
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Description of Research Expertise
30 Ongoing Methodological Research1bb Dr. Feng’s current research focuses on exploring and improving the potential of deep learning methodologies, for structured input variables in biomedical research. Her recent development of the peel learning model, structure-guided transformer models, and redefined interpretability, contribute to ongoing efforts to address pragmatic challenges such as limited sample sizes and the underutilization of correlations among predictors.
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33 Past Contributions in Genetics and Genomics
1f2 In the past, Dr. Feng has been devoted to statistical modeling for complex and high-dimensional genetic and genomic studies. Her early contributions include innovative models for testing familial segregation, gene mapping, and adjustment for sampling bias in ordinal traits. Later, she developed multiple haplotype-based methods for joint SNP-CNV calling, analysis of parent-of-origin effects in SNP and sequence data, instrumental variable selection, and high-dimensional causal inference.
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33 Leadership in Multi-Center Clinical Studies
3a4 Dr. Feng has directed the design and data management of several high-impact multi-center clinical studies, including a pediatric study of the respiratory outcomes of extremely preterm infants (PROP, 2010-2016), a trial of novel Peg-IFN-a2b treatment in HIV patients (BEAT-HIV, 2013-2018), a multicenter pragmatic trial to evaluate the surgery outcomes of hip-fracture patients receiving spinal vs. general anesthesia (REGAIN, 2015-2021), a phase-II Lenabasum treatment trial in dermatomyositis (Lenabasum, 2015-2018), a phase-II trial to determine the effectiveness of anastrozole on pulmonary arterial hypertension (PHANTOM, 2016-2022), and a stepped-wedge clustered randomized trial of nudges to reduce benzodiazepine use in senior surgical patients (DROP-BENZO, 2022-24). These projects have set high standards in data quality and have been instrumental in producing high-impact publications in top-tier medical journals.
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2a Mentorship and Academic Leadership
180 Dr. Feng has mentored over 20 medical fellows, numerous Master’s and Ph.D. students, and 4 postdoctoral fellows, guiding them through successful research careers. Since joining Penn Biostatistics in August 2009—following her faculty appointment at the University of Alabama at Birmingham—she has continued to foster a rich environment for academic growth and innovation.
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6e Dr. Feng currently serves as the Treasurer of the International Chinese Statistical Association (ICSA).
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122 Liu J, Pan M, Sun M, Shi H, Feng R. : Nutritional Status and Physical Exercise Are Associated with Cognitive Function in Chinese Community-Dwelling Older Adults: The Role of Happiness. Nutrients 16(2): 203, Jan 2024.
18c Kawut, S. M., Feng, R., Ellenberg, S. S., Zamanian, R., Bull, T., Chakinala, M., Mathai, S. C., Hemnes, A., Lin, G., Doyle, M., Andrew, R., MacLean, M., Stasinopoulos, I., Austin, E., DeMichele, A., Song, N., Moutchia, J., Ventetuolo, C. E. : Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double blind, Placebo-controlled Trial 70 American Journal of Respiratory and Critical Care Medicine 210(9): 1143-1151, Nov 2024.
14f Liu J, Yang Y, Shi H, Sun M, Feng R; Finger Exercise Group.: Developing and evaluating a mindfulness-based finger/hand exercise intervention for ethnically diverse older adults with and without disabilities: A feasibility study. Geriatr Nurs. 56: 148-158, 2024.
343 Kyra O’Brien, Rui Feng, Frederick Sieber, Edward R. Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L. Carson, Derek Dillane, Daniel I. Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S. Schwenk, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Jason Karlawish, Samir Mehta, Derek J. Donegan, Annamarie Horan, Susan S. Ellenberg, Mark D. Neuman : Outcomes with spinal versus general anesthesia for patients with and without preoperative cognitive impairment: secondary analysis of a randomized clinical trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 19(9): 4008-4019, Sep 2023.
25c Neuman MD, Feng R, Carson JL, Gaskins LJ, Dillane D, Sessler DI, Sieber F, Magaziner J, Marcantonio E, Mehta S, Menio D, Ayad S, Stone T, Papp S, Schwenk ES, Elkassabany N, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin K-J, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Giska M, Ranganath Y, Tedore T, Choi S, Li J, Kwofie MK, Nader A, Sanders RD, Allen BFS, Vlassakov K, Kates S, Fleisher LA, Dattilo J, Tierney A, Stephens-Shields AJ, Ellenberg S: Spinal Anesthesia Versus General Anesthesia for Hip Surgery in Older Adults 2 56 New England Journal of Medicine 385(22): 2025-2035, Nov 2021.
b1 Li Y, Wang F, Yan M, Cantu E, Yang FN, Rao H, Feng R: Peel Learning for Pathway-Related Outcome Prediction. Bioinformatics 31 37(22): 4108-4114, Nov 2021.
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Selected Publications
248 Vail EA, Feng R, Sieber F, Carson JL, Ellenberg SS, Magaziner J, Dillane D, Marcantonio ER, Sessler DI, Ayad S, Stone T, Papp S, Donegan D, Mehta S, Schwenk ES, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Tierney A, Horan AD, Neuman MD; REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) Investigators.: Long-term outcomes with spinal versus general anesthesia for hip fracture surgery: A randomized trial. Anesthesiology 2 31 140(3): 375-386, March 2024.122 Liu J, Pan M, Sun M, Shi H, Feng R. : Nutritional Status and Physical Exercise Are Associated with Cognitive Function in Chinese Community-Dwelling Older Adults: The Role of Happiness. Nutrients 16(2): 203, Jan 2024.
18c Kawut, S. M., Feng, R., Ellenberg, S. S., Zamanian, R., Bull, T., Chakinala, M., Mathai, S. C., Hemnes, A., Lin, G., Doyle, M., Andrew, R., MacLean, M., Stasinopoulos, I., Austin, E., DeMichele, A., Song, N., Moutchia, J., Ventetuolo, C. E. : Pulmonary Hypertension and Anastrozole (PHANTOM): A Randomized, Double blind, Placebo-controlled Trial 70 American Journal of Respiratory and Critical Care Medicine 210(9): 1143-1151, Nov 2024.
14f Liu J, Yang Y, Shi H, Sun M, Feng R; Finger Exercise Group.: Developing and evaluating a mindfulness-based finger/hand exercise intervention for ethnically diverse older adults with and without disabilities: A feasibility study. Geriatr Nurs. 56: 148-158, 2024.
343 Kyra O’Brien, Rui Feng, Frederick Sieber, Edward R. Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L. Carson, Derek Dillane, Daniel I. Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S. Schwenk, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Jason Karlawish, Samir Mehta, Derek J. Donegan, Annamarie Horan, Susan S. Ellenberg, Mark D. Neuman : Outcomes with spinal versus general anesthesia for patients with and without preoperative cognitive impairment: secondary analysis of a randomized clinical trial. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 19(9): 4008-4019, Sep 2023.
25c Neuman MD, Feng R, Carson JL, Gaskins LJ, Dillane D, Sessler DI, Sieber F, Magaziner J, Marcantonio E, Mehta S, Menio D, Ayad S, Stone T, Papp S, Schwenk ES, Elkassabany N, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin K-J, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Giska M, Ranganath Y, Tedore T, Choi S, Li J, Kwofie MK, Nader A, Sanders RD, Allen BFS, Vlassakov K, Kates S, Fleisher LA, Dattilo J, Tierney A, Stephens-Shields AJ, Ellenberg S: Spinal Anesthesia Versus General Anesthesia for Hip Surgery in Older Adults 2 56 New England Journal of Medicine 385(22): 2025-2035, Nov 2021.
b1 Li Y, Wang F, Yan M, Cantu E, Yang FN, Rao H, Feng R: Peel Learning for Pathway-Related Outcome Prediction. Bioinformatics 31 37(22): 4108-4114, Nov 2021.
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5b © The Trustees of the University of Pennsylvania | Site best viewed a in a supported browser. | Site Design: 57 PMACS Web Team. 3 22
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