Faculty

Adam Christian Naj, PhD

faculty photo
Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
921 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
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Description of Research Expertise

Dr. Naj is an Assistant Professor of Epidemiology in the Department of Biostatistics, Epidemiology, and Informatics, and the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research focuses primarily on the genetics of Alzheimer’s Disease (AD) and neurodegeneration, including his genome-wide association analyses in the Alzheimer’s Disease Genetics Consortium (ADGC) which resulted in a first-author paper that was the most cited Alzheimer’s study of 2011. Joining Penn in 2012, Dr. Naj has extended his roles in analysis and data management in the ADGC, and has been actively co-leading quality control and case-control analysis working groups in the Alzheimer’s Disease Sequencing Project (ADSP), which has collected data on nearly 600 whole genomes and more than 10,500 whole exomes of AD cases and controls to identify rare risk-increasing and protective genomic variants contributing to AD. Of late his work has included guiding development of a quality control pipeline for next-generation sequence data as part of the Genomic Center on Alzheimer’s Disease (GCAD). Dr. Naj is also one of several Penn co-founders and organizers of the annual Symposium on Advances in Genetic Epidemiology and Statistics (SAGES), promoting the development of methods to analyze genomic datasets. He has recently expanded his research portfolio to include studies examining genetic loci contributing to multiple neurodegenerative diseases and phenotypes including AD, Parkinson’s disease, and progressive supranuclear palsy, among others, aspiring to identify key genetic contributors to the pathologies underlying neurodgeneration.

Selected Publications

Naj Adam C, Reitz Christiane, Rajabli Farid, Jun Gyungah R, Benchek Penelope, Tosto Giuseppe, Sha Jin, Zhu Congcong, Kushch Nicholas A, Lee Wan-Ping, Haut Jacob, Hamilton-Nelson Kara L, Wheeler Nicholas R, Zhao Yi, Farrell John, Chung Jaeyoon, Grunin Michelle, Leung Yuk Yee, Li Donghe, Lucio da Fonseca Eder, Mez Jesse B, Palmer Ellen L, Pillai Jagan A, Sherva Richard, Song Yeunjoo E, Zhang Xiaoling, Iqbal Taha, Pathak Omkar, Valladares Otto, Kuzma Amanda B, Kunkle Brian W, Bush William S, Wang Li-San, Farrer Lindsay A, Haines Jonathan L., Mayeux Richard, Pericak-Vance Margaret A, Schellenberg Gerard D.: Multi-Ancestry Genome-wide Association Analysis (GWAS) of Late-Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross-Ancestry Association in LRRC4C. American Society of Human Genetics (ASHG) Annual Meeting, Los Angeles, CA, USA October 2022.

Woodward Alexa A, Urbanowicz Ryan J, Naj Adam C, Moore Jason H.: Genetic heterogeneity: Challenges, impacts, and methods through an associative lens. Genet Epidemiol August 2022.

Naj Adam C, Reitz Christiane, Rajabli Farid, Jun Gyungah R, Benchek Penelope, Tosto Giuseppe, Sha Jin, Zhu Congcong, Kushch Nicholas A, Lee Wan-Ping, Haut Jacob, Hamilton-Nelson Kara L, Wheeler Nicholas R, Zhao Yi, Farrell John, Chung Jaeyoon, Grunin Michelle, Leung Yuk Yee, Li Donghe, Lucio da Fonseca Eder, Mez Jesse B, Palmer Ellen L, Pillai Jagan A, Sherva Richard, Song Yeunjoo E, Zhang Xiaoling, Iqbal Taha, Pathak Omkar, Valladares Otto, Kuzma Amanda B, Kunkle Brian W, Bush William S, Wang Li-San, Farrer Lindsay A, Haines Jonathan L., Mayeux Richard, Pericak-Vance Margaret A, Schellenberg Gerard D. : Multi-Ancestry Genome-wide Association Analysis (GWAS) of Late-Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross-Ancestry Association in LRRC4C. Alzheimer's Association International Conference (AAIC), San Diego, CA, USA July 2022.

Luo Chongliang, Duan Rui, Naj Adam C, Kranzler Henry R, Bian Jiang, Chen Yong.: ODACH: a one-shot distributed algorithm for Cox model with heterogeneous multi-center data. Sci Rep 12: 6627, April 2022.

Jin B, Capra JA, Benchek P, Wheeler N, Naj AC, Hamilton-Nelson KL, Farrell JJ, Leung YY, Kunkle B, Vadarajan B, Schellenberg GD, Mayeux R, Wang LS, Farrer LA, Pericak-Vance MA, Martin ER, Haines JL, Crawford DC, Bush WS.: An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns. Genome Res 32(4): 778-90, April 2022.

Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, Kuulasmaa T, Yang Q, de Rojas I, Bis JC, Yaqub A, Prokic I, Chapuis J, Ahmad S, Giedraitis V, Aarsland D, Garcia-Gonzalez P, Abdelnour C, Alarcón-Martín E, Alcolea D, Alegret M, Alvarez I, Álvarez V, Armstrong NJ, Tsolaki A, Antúnez C, Appollonio I, Arcaro M, Archetti S, Pastor AA, Arosio B, Athanasiu L, Bailly H, Banaj N, Baquero M, Barral S, Beiser A, Pastor AB, Below JE, Benchek P, Benussi L, Berr C, Besse C, Bessi V, Binetti G, Bizarro A, Blesa R, Boada M, Boerwinkle E, Borroni B, Boschi S, Bossù P, Bråthen G, Bressler J, Bresner C, Brodaty H, Brookes KJ, Brusco LI, Buiza-Rueda D, Bûrger K, Burholt V, Bush WS, Calero M, Cantwell LB, Chene G, Chung J, Cuccaro ML, Carracedo Á, Cecchetti R, Cervera-Carles L, Charbonnier C, Chen HH, Chillotti C, Ciccone S, Claassen JAHR, Clark C, Conti E, Corma-Gómez A, Costantini E, Custodero C, Daian D, Dalmasso MC, Daniele A, Dardiotis E, Dartigues JF, de Deyn PP, de Paiva Lopes K, de Witte LD, Debette S, Deckert J, Del Ser T, et al.: New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet 54(4): 412-36, April 2022.

Heath Laura, Earls John C, Magis Andrew T, Kornilov Sergey A, Lovejoy Jennifer C, Funk Cory C, Rappaport Noa, Logsdon Benjamin A, Mangravite Lara M, Kunkle Brian W, Martin Eden R, Naj Adam C, Ertekin-Taner Nilufer, Golde Todd E, Hood Leroy, Price Nathan D; Alzheimer’s Disease Genetics Consortium.: Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Sci Rep 12: 6117, April 2022.

Kuksa PP, Liu CL, Fu W, Qu L, Zhao Y, Katanic Z, Clark K, Kuzma AB, Ho PC, Tzeng KT, Valladares O, Chou SY, Naj AC, Schellenberg GD, Wang LS, Leung YY.: Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease. J Alzheimers Dis 86(1): 461-77, March 2022.

Chen HH, Petty LE, Sha J, Zhao Y, Kuzma A, Valladares O; Alzheimer’s Disease Genetics Consortium, International Genomics of Alzheimer’s Project, Bush W, Naj AC, Gamazon ER, Below JE.: Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci. Transl Psychiatry 11: 618, December 2021.

de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, González-Perez A, Calero M, Franco-Macías E, Macías J, Blesa R, Cervera-Carles L, Menéndez-González M, Frank-García A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Alarcón-Martín E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, Pérez-Cordón A, Benussi A, Rábano A, Padovani A, Squassina A, de Mendonça A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes A, Sanabria Á, DeStefano AL, Schneider A, Haapasalo A, Kinhult Ståhlbom A, Tybjærg-Hansen A, Hartmann AM, Spottke A, Corbatón-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Martínez Rodríguez C, Muñoz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Grünblatt E, Dardiotis E, Düzel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, et al.: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 12: 3417, June 2021.

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Last updated: 11/11/2022
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