Faculty

Adam Christian Naj, PhD

faculty photo
Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
229 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
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Description of Research Expertise

Dr. Naj is an Assistant Professor of Epidemiology in the Department of Biostatistics, Epidemiology, and Informatics, and the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research focuses primarily on the genetics of Alzheimer’s Disease (AD) and neurodegeneration, including his genome-wide association analyses in the Alzheimer’s Disease Genetics Consortium (ADGC) which resulted in a first-author paper that was the most cited Alzheimer’s study of 2011. Joining Penn in 2012, Dr. Naj has extended his roles in analysis and data management in the ADGC, and has been actively co-leading quality control and case-control analysis working groups in the Alzheimer’s Disease Sequencing Project (ADSP), which has collected data on nearly 600 whole genomes and more than 10,500 whole exomes of AD cases and controls to identify rare risk-increasing and protective genomic variants contributing to AD. Of late his work has included guiding development of a quality control pipeline for next-generation sequence data as part of the Genomic Center on Alzheimer’s Disease (GCAD). Dr. Naj is also one of several Penn co-founders and organizers of the annual Symposium on Advances in Genetic Epidemiology and Statistics (SAGES), promoting the development of methods to analyze genomic datasets. He has recently expanded his research portfolio to include studies examining genetic loci contributing to multiple neurodegenerative diseases and phenotypes including AD, Parkinson’s disease, and progressive supranuclear palsy, among others, aspiring to identify key genetic contributors to the pathologies underlying neurodgeneration.

Selected Publications

Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, DeJager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang L-S, Hyman BT, Kukull WA, Foroud TA, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR; Alzheimer’s Disease Genetics Consortium: Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications 11(1): 667, February 2020.

A.C. Naj; J. Sha 1; G. Leonenko 3; X. Jian 4; B. Grenier-Boley 5; M. Leber 6; S. van der Lee 7; R. Sims 8; V. Chouraki 5; J.C. Bis 9; Y. Zhao 2; A. Kuzma 2; B.W. Kunkle 10; H. Comic 11; A. Pitsillides 12; R. Xia 13; P. Holmans 8; L.-S. Wang 2; R.P. Mayeux 14; L.A. Farrer 12,15; C. van Duijn 11,16; J.L. Haines 17; A.L. DeStefano 12; M.A. Pericak-Vance 10,18; A. Ramirez 6; P. Amouyel 5; J.-C. Lambert 5; S. Seshadri 19; J. Williams 8; G.D. Schellenberg 2; International Genomics of Alzheimer's Project (IGAP): Genome-wide rare variant imputation in 60,178 subjects identifies novel rare variant candidate loci in late-onset Alzheimer’s disease (LOAD): The International Genomics of Alzheimer’s Project (IGAP). American Society of Human Genetics (ASHG) Annual Meeting, Houston, TX, USA October 2019.

Y.J. Li 1,2; S.H. Slifer 3,4; S. Sun 1; M.A. Schmidt 3,4; A.C. Naj 5; X.R. Gao 6; E.R. Martin 3,4; Alzheimer Disease Genetics Consortium (ADGC): Genome wide meta- and mega-analysis for identifying genes modifying age-at-onset of Alzheimer disease in the ADGC cohorts. American Society of Human Genetics (ASHG) Annual Meeting, Houston, TX, USA October 2019.

L. Qu 1; Y. Zhao 1; E.E. Mlynarski 1; M. Tang 1; W. Wang 1; J.M. Ringman 2; L.S. Wang 1; G.D. Schellenberg 1; A.C. Naj 1,3; Alzheimer's Disease Genetics Consortium (ADGC): Genetics of handedness in Alzheimer's disease. American Society of Human Genetics (ASHG) Annual Meeting, Houston, TX, USA October 2019.

Y. Zhao 1; E.E. Mlynarski 1; W. Wang 1; A. Kuzma 1; L.-S. Wang 1; G.D. Schellenberg 1; A.C. Naj 1,2; PSP Genetics Study Group: Genome-wide association analyses of progressive supranuclear palsy identifies novel loci. American Society of Human Genetics (ASHG) Annual Meeting, Houston, TX, USA October 2019.

B.W. Kunkle 1; K.L. Hamilton-Nelson 1; L. Gomez 1; M. Jean-Francois 1; A.C. Naj 2; L. Wang 1; A.B. Kuzma 2; G.W. Beecham 1; W.S. Bush 3; T. Hohman 4; B.N. Vardarajan 5; L.S. Wang 2; R. Mayeux 4; J.L. Haines 5; L.A. Farrer 6; G.D. Schellenberg 2; M.A. Pericak-Vance 1; E.R. Martin 1; Alzheimer's Disease Genetics Consortium: Genome-wide analyses identify novel sex-specific candidate loci for Alzheimer disease. American Society of Human Genetics (ASHG) Annual Meeting, Houston, TX, USA October 2019.

Ma Yiyi, Jun Gyungah R, Chung Jaeyoon, Zhang Xiaoling, Kunkle Brian W, Naj Adam C, White Charles C, Bennett David A, De Jager Philip L, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Farrer Lindsay A, Lunetta Kathryn L: CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. Aging cell 18(4): e12964, Aug 2019.

Ma Yiyi, Jun Gyungah R, Zhang Xiaoling, Chung Jaeyoon, Naj Adam C, Chen Yuning, Bellenguez Celine, Hamilton-Nelson Kara, Martin Eden R, Kunkle Brian W, Bis Joshua C, Debette Stéphanie, DeStefano Anita L, Fornage Myriam, Nicolas Gaël, van Duijn Cornelia, Bennett David A, De Jager Philip L, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Seshadri Sudha, Lambert Jean-Charles, Schellenberg Gerard D, Lunetta Kathryn L, Farrer Lindsay A: Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA neurology Jun 2019.

Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier J-G, Harold D, Fitzpatrick AL, Valladares O, Moutet M-L, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi S-H, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, St George-Hyslop P, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu C-K, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin L-W, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel K-H, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann H-E, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, Quinn JF, Sacchinelli E, Raj A, Spalletta G, Raskind M, Caltagirone C, Bossù P, Orfei MD, Reisberg B, Clarke R, Reitz C, Smith AD, Ringman JM, Warden D, Roberson ED, Wilcock G, Rogaeva E, Bruni AC, Rosen HJ, Gallo M, Rosenberg RN, Ben-Shlomo Y, Sager MA, Mecocci P, Saykin AJ, Pastor P, Cuccaro ML, Vance JM, Schneider JA, Schneider LS, Slifer S, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tang M, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu C-E, Yu L, Saba Y, Pilotto A, Bullido MJ, Peters O, Crane PK, Bennett D, Bosco P, Coto E, Boccardi V, De Jager PL, Lleo A, Warner N, Lopez OL, Ingelsson M, Deloukas P, Cruchaga C, Graff C, Gwilliam R, Fornage M, Goate AM, Sanchez-Juan P, Kehoe PG, Amin N, Ertekin-Taner N, Berr C, Debette S, Love S, Launer LJ, Younkin SG, Dartigues J-F, Corcoran C, Ikram MA, Dickson DW, Nicolas G, Campion D, Tschanz J, Schmidt H, Hakonarson H, Clarimon J, Munger R, Schmidt R, Farrer LA, Van Broeckhoven C, O'Donovan MC, DeStefano AL, Jones L, Haines JL, Deleuze J-F, Owen MJ, Gudnason V, Mayeux R, Escott-Price V, Psaty BM, Ramirez A, Wang L-S, Ruiz A, van Duijn CM, Holmans PA, Seshadri S, Williams J, Amouyel P, Schellenberg GD, Lambert J-C, Pericak-Vance MA: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51(3): 414-430, March 2019.

Hu Y, Li M, Lu Q, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Gu J, Muchnik S, Shi Y, Kunkle BW, Mukherjee S, Natarajan P, Naj A, Kuzma A, Zhao Y, Crane PK, Lu H, Zhao H: A statistical framework for cross-tissue transcriptome-wide association analysis. Nature Genetics 51(3): 568-576, March 2019.

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Last updated: 03/04/2020
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