Sharon Xiangwen Xie, Ph.D.
University of Pennsylvania
Perelman School of Medicine
607 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Beijing Polytechnic University (Applied Mathematics), 1991.
University of Texas (Statistics), 1993.
University of Washington (Biostatistics), 1995.
University of Washington (Biostatistics), 1997.
Description of Research ExpertiseDr. Xie is currently principal investigator of an NIH-funded statistical method R01 grant that aims to develop novel statistical methods for assessing dementia risk in Parkinson's disease and related disorders. She is also the principal investigator and director of the biostatistics and data management core for three NIH-funded neurodegenerative disease research centers/program project grants: the Alzheimer's Disease Center, Center on Alpha-Synuclein Strains in Alzheimer's Disease and Related Disorders, and the frontotemporal lobar degeneration program project grant.
Dr. Xie's current research goals are twofold. First, she continues to develop new statistical methods for survival analysis, missing data, measurement error problems, high dimensional data, biomarker evaluations, longitudinal analysis, and receiver operating characteristic (ROC) analysis in response to methodological problems that arise in her collaborative work in the research of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis) and in other collaborative research. Second, she continues to study biomarkers to improve disease-modifying therapy development and early detection in neurodegenerative diseases.
Awards and Professional Recognition:
Dr. Xie is an elected Fellow of the American Statistical Association. She is currently an Associate Editor of Alzheimer's & Dementia. She is also an elected standing member of the Parkinson Study Group Scientific Review Committee (2016 – present). Dr. Xie was the recipient of the 1999 Young Investigator Award of Statistics in the Epidemiology Section of the American Statistical Association, and in 2005 and 2011 she received the University of Pennsylvania Graduate Program in Biostatistics Teaching Award. She was an elected standing member of the National Institute of Aging Alzheimer's Disease Center Data Core Steering Committee during 2007 and 2010 (Chair during July 2008 and July 2009). She was an elected standing member of the National Alzheimer's Coordinating Center (NACC) Scientific Review Committee for National Institute of Aging (2015-2019).
Sharon Xie’s Research Lab:
Sharon Xie, PhD, Professor of Biostatistics
Panpan Zhang, PhD, postdoctoral researcher
Carrie Caswell, PhD student in biostatistics
Hayley Richardson, PhD student in biostatistics
Previous PhD students who completed PhD dissertation under Dr. Xie’s supervision:
Matthew White, PhD, 2012
Dissertation title: Statistical Methods for Evaluating Diagnostic Biomarkers in the Presence of Measurement Error
First job: Instructor, Harvard Medical School;
Honors: Winner of 2011 Young Investigator Award from Statistics in Epidemiology Section of American Statistical Association and 2012 ENAR Distinguished Student Paper Award
Jarcy Zee, PhD, 2014
Dissertation title: Survival Analysis with Uncertain Endpoints Using an Internal Validation Subsample
First job: Research Scientist, Arbor Research Collaborative for Health
Honors: Winner of 2014 Student Travel Award from the Biometrics Section of the American Statistical Association
Lior Rennert, PhD, 2018
Dissertation title: Statistical Methods for Truncated Survival Data
First job: Tenure-track Assistant Professor of Biostatistics, Department of Public Health Sciences, Clemson University
Honors: Winner of W. Edwards Deming Student Scholar Award from the 2017 Annual Deming Conference on Applied Statistics.
Leah Suttner, PhD, 2019
Dissertation Title: Statistical Methods for Censored and Missing Data in Survival and Longitudinal Analysis
First job: Senior Scientist, Biostatistics at Merck
Honors: Winner of 2016 Biopharmaceutical Applied Statistics Symposium (BASS) Student Travel Award; GlaxoSmithKline Graduate Student Fellowship, 2016-2019
Selected PublicationsXie, S.X., Wang, C.Y., Prentice, R.L.: A risk set calibration method for failure time regression by using a covariate reliability sample. Journal of the Royal Statistical Society, Series B 63(4): 855-870, 2001.
Xie, S.X., Liao, D., Chinchilli, V.M.: Measurement error reduction using weighted average method for repeated measurements from heterogeneous instruments. Environmetrics 12(8): 785-790, 2001.
Clark, C.M., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J.C., McKeel, D.W. Jr., Farlow, M., Weitlauf, S.L., Quinn, J., Kaye, J., Knopman, D., Arai, H., Doody, R.S., DeCarli, C., Leight, S., Lee, V.M.-Y., Trojanowski, J.Q.: Cerebrospinal fluid tau and beta-amyloid: How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Archives of Neurology 60(12): 1696-1702, 2003.
Brown, G.K., Ten Have, T., Henriques, G.R., Xie, S.X., Hollander, J.E., Beck, A.T.: Cognitive therapy for the prevention of suicide attempts: A randomized controlled trial. Journal of the American Medical Association 294(5): 563-570, 2005.
Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E.B., Xie, S.X., Joyce, S., Li, C., Toleikis, P.M., Lee, V.M.-Y., Trojanowski, J.Q.: Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Science 102(1): 227-231, 2005.
Xie, S.X., Forman, M.S., Farmer J., Moore, P., Wang, Y., Wang, X, Clark, C.M., Coslett, H.B., Chatterjee, A., Arnold, S.E., Rosen, H., Karlawish, J.H., Van Deerlin, V.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M.: Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry 79(2): 126-129, 2008.
Grossman, M., Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Berkowitz, R., Chatterjee, A., Coslett, H.B., Hurtig, H.I., Forman, M.S., Lee, V.M.-Y., Trojanowski, J.Q. : Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology 70(22): 2036-2045, 2008.
Xie, S.X., Ewbank, D.C., Chittams, J., Karlawish, J.H.T., Arnold, S.E., Clark, C.M. : Rate of decline in Alzheimer disease measured by a dementia severity rating scale. Alzheimer Disease & Associated Disorders 23(3): 268-274, 2009.
Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Khan, A, Chatterjee, A., Coslett, H.B., Hurtig, H.I., Liang, T.-W., Grossman, M.: Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's disease. Journal of the International Neuropsychological Society 16(2): 278-286, 2010.
Siderowf, A., Xie, S.X., Hurtig, H., Weintraub, D., Duda, J., Chen-Plotkin, A., Shaw, L.M., Van Deerlin, V., Trojanowski, J.Q., Clark, C.: CSF Amyloid Beta 1-42 predicts cognitive decline in Parkinson's disease. Neurology 75(12): 1055-1061, 2010.
Xie, S.X., Baek, Y., Grossman, M., Arnold, S.E., Karlawish, J., Siderowf, A., Hurtig, H., Elman, L., McCluskey, L., Van Deerlin, V., Lee, V.M.-Y., Trojanowski, J.Q.: Building an integrated neurodegenerative disease database at an academic health center. Alzheimer’s & Dementia 7(4): e84-e93, 2011.
Mao, J.J., Palmer, S.C., Desai, K., Li, S.Q., Armstrong, K., Xie, S.X.: Development and validation of an instrument for measuring attitudes and beliefs about Complementary and Alternative Medicine (CAM) use among cancer patients. Evidence-Based Complementary and Alternative Medicine 2012: 798098, 2012 Notes: doi: 10.1155/2012/798098.
*Tan, K., Libon, D.J., Rascovsky, K., Grossman, M., Xie, S.X.: Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer's Disease. Alzheimer Disease & Associated Disorders 27(4): 310-5, 2013 Notes: *first author was a biostatistics M.S. degree student to whom I served as the thesis advisor.
*White, M.T., Xie, S.X.: Adjustment for measurement error in evaluating diagnostic biomarkers by using an internal reliability sample. Statistics in Medicine 32(27): 4709-25, 2013 Notes: *first author was a biostatistics doctoral student to whom I served as dissertation advisor. This work earned Dr. White the 2011 Young Investigator Award from Statistics in Epidemiology Section of American Statistical Association and 2012 ENAR Distinguished Student Paper Award.
Toledo, J.B., Xie, S.X.#, Trojanowski, J.Q., Shaw, L.M.; for the Alzheimer's Disease Neuroimaging Initiative: Longitudinal change in CSF Tau and Abeta biomarkers for up to 48 months in ADNI. Acta Neuropathologica 126(5): 659-70, 2013 Notes: #Dr. Xie is a co-first author.
Papay, K., Xie, S.X., Stern, M., Hurtig, H., Siderowf, A., Duda, J.E., Minger, J., Weintraub, D.: Naltrexone for impulse control disorders in Parkinson’s disease: a placebo-controlled study. Neurology 83(9): 826-33, 2014.
Mao, J.J., Farrar, J.T., Bruner, D., Zee, J., Bowman, M., Seluzicki, C., DeMichele, A., Xie, S.X. : Electro-acupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial. Cancer 120(23): 3744-51, 2014.
*Zee, J., Xie, S.X.: Nonparametric discrete survival function estimation with uncertain endpoints using an internal validation subsample. Biometrics 71(3): 772-81, 2015 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor. This paper earned Dr. J. Zee a 2014 Student Travel Award from the Biometrics Section of the American Statistical Association.
*Zee, J., Xie, S.X.; for the Alzheimer's Disease Neuroimaging Initiative: Assessing treatment effects with surrogate survival outcomes using an internal validation subsample. Clinical Trials 12(4): 333-41, 2015 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.
*Zee, J., Xie, S.X.: The Kaplan-Meier Method for Estimating and Comparing Proportions in a Randomized Controlled Trial with Dropouts. Biostatistics & Epidemiology 2(1): 23-33, 2018 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.
*Rennert, L., Xie, S.X.: Cox regression model with doubly truncated data. Biometrics 74(2): 725-733, Jun 2018 Notes: *first author is a biostatistics doctoral student to whom I served as the dissertation advisor. This paper earned Mr. Rennert the W. Edwards Deming Student Scholar Award from the 2017 Annual Deming Conference on Applied Statistics.
*Rennert, L., Xie, S.X.: Bias induced by ignoring double truncation inherent in autopsy-confirmed survival studies of neurodegenerative diseases. Statistics in Medicine 38(19): 3599-3613, 2019 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.