Sharon Xiangwen Xie, Ph.D.

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Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics, Epidemiology and Informatics
University of Pennsylvania
Perelman School of Medicine
607 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: (215) 573-3867
Fax: 215-573-4865
Beijing Polytechnic University (Applied Mathematics), 1991.
University of Texas (Statistics), 1993.
University of Washington (Biostatistics), 1995.
University of Washington (Biostatistics), 1997.
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Description of Research Expertise

Dr. Xie is currently principal investigator of an NIH-funded statistical method R01 grant that aims to develop novel statistical methods for assessing dementia risk in Parkinson's disease and related disorders. She is also the director and principal investigator of the biostatistics and data management core for three NIH-funded neurodegenerative disease research centers/program project grants: the Alzheimer's Disease Center, Center on Alpha-Synuclein Strains in Alzheimer's Disease and Related Disorders, and the frontotemporal lobar degeneration program project grant. Please see Sharon Xie's Research Lab Website (https://sites.google.com/view/sharonxielab/) for additonal details about her team members and research. 

Dr. Xie's current research goals are twofold. First, she continues to develop new statistical methods for survival analysis, missing data, measurement error problems, high dimensional data, biomarker evaluations, and longitudinal analysis in response to methodological problems that arise in her collaborative work in the research of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis) and in other collaborative research. Second, she continues to study epidemiology of neurodegenerative diseases.

Dr. Xie is an elected Fellow of the American Statistical Association. She is currently an Associate Editor of Alzheimer's & Dementia. She was the program chair for the Biometrics Section of 2019 Joint Statistical Meetings. She is a former chair of the National Institute on Aging Alzheimer's Disease Center Data Core Steering Committee. She has served as an elected standing member of the Parkinson Study Group Scientific Review Committee (2016 – 2019) and the National Alzheimer's Coordinating Center (NACC) Scientific Review Committee for the National Institute on Aging (2015-2019). Dr. Xie was the recipient of the 1999 Young Investigator Award of Statistics in the Epidemiology Section of the American Statistical Association, and in 2005 and 2011 she received the University of Pennsylvania Graduate Program in Biostatistics Teaching Award.

Selected Publications

Xie, S.X., Wang, C.Y., Prentice, R.L.: A risk set calibration method for failure time regression by using a covariate reliability sample. Journal of the Royal Statistical Society, Series B 63(4): 855-870, 2001.

Xie, S.X., Liao, D., Chinchilli, V.M.: Measurement error reduction using weighted average method for repeated measurements from heterogeneous instruments. Environmetrics 12(8): 785-790, 2001.

Clark, C.M., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J.C., McKeel, D.W. Jr., Farlow, M., Weitlauf, S.L., Quinn, J., Kaye, J., Knopman, D., Arai, H., Doody, R.S., DeCarli, C., Leight, S., Lee, V.M.-Y., Trojanowski, J.Q.: Cerebrospinal fluid tau and beta-amyloid: How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Archives of Neurology 60(12): 1696-1702, 2003.

Brown, G.K., Ten Have, T., Henriques, G.R., Xie, S.X., Hollander, J.E., Beck, A.T.: Cognitive therapy for the prevention of suicide attempts: A randomized controlled trial. Journal of the American Medical Association 294(5): 563-570, 2005.

Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E.B., Xie, S.X., Joyce, S., Li, C., Toleikis, P.M., Lee, V.M.-Y., Trojanowski, J.Q.: Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Science 102(1): 227-231, 2005.

Xie, S.X., Forman, M.S., Farmer J., Moore, P., Wang, Y., Wang, X, Clark, C.M., Coslett, H.B., Chatterjee, A., Arnold, S.E., Rosen, H., Karlawish, J.H., Van Deerlin, V.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M.: Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry 79(2): 126-129, 2008.

Grossman, M., Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Berkowitz, R., Chatterjee, A., Coslett, H.B., Hurtig, H.I., Forman, M.S., Lee, V.M.-Y., Trojanowski, J.Q. : Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology 70(22): 2036-2045, 2008.

Xie, S.X., Ewbank, D.C., Chittams, J., Karlawish, J.H.T., Arnold, S.E., Clark, C.M. : Rate of decline in Alzheimer disease measured by a dementia severity rating scale. Alzheimer Disease & Associated Disorders 23(3): 268-274, 2009.

Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P., Vesely, L., Khan, A, Chatterjee, A., Coslett, H.B., Hurtig, H.I., Liang, T.-W., Grossman, M.: Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's disease. Journal of the International Neuropsychological Society 16(2): 278-286, 2010.

Siderowf, A., Xie, S.X., Hurtig, H., Weintraub, D., Duda, J., Chen-Plotkin, A., Shaw, L.M., Van Deerlin, V., Trojanowski, J.Q., Clark, C.: CSF Amyloid Beta 1-42 predicts cognitive decline in Parkinson's disease. Neurology 75(12): 1055-1061, 2010.

Xie, S.X., Baek, Y., Grossman, M., Arnold, S.E., Karlawish, J., Siderowf, A., Hurtig, H., Elman, L., McCluskey, L., Van Deerlin, V., Lee, V.M.-Y., Trojanowski, J.Q.: Building an integrated neurodegenerative disease database at an academic health center. Alzheimer’s & Dementia 7(4): e84-e93, 2011.

Mao, J.J., Palmer, S.C., Desai, K., Li, S.Q., Armstrong, K., Xie, S.X.: Development and validation of an instrument for measuring attitudes and beliefs about Complementary and Alternative Medicine (CAM) use among cancer patients. Evidence-Based Complementary and Alternative Medicine 2012: 798098, 2012.

*Tan, K., Libon, D.J., Rascovsky, K., Grossman, M., Xie, S.X.: Differential Longitudinal Decline on the Mini-Mental State Examination in Frontotemporal Lobar Degeneration and Alzheimer's Disease. Alzheimer Disease & Associated Disorders 27(4): 310-5, 2013 Notes: *first author was a biostatistics M.S. degree student to whom I served as the thesis advisor.

*White, M.T., Xie, S.X.: Adjustment for measurement error in evaluating diagnostic biomarkers by using an internal reliability sample. Statistics in Medicine 32(27): 4709-25, 2013 Notes: *first author was a biostatistics doctoral student to whom I served as dissertation advisor. This work earned Dr. White the 2011 Young Investigator Award from Statistics in Epidemiology Section of American Statistical Association and 2012 ENAR Distinguished Student Paper Award.

Toledo, J.B., Xie, S.X.#, Trojanowski, J.Q., Shaw, L.M.; for the Alzheimer's Disease Neuroimaging Initiative: Longitudinal change in CSF Tau and Abeta biomarkers for up to 48 months in ADNI. Acta Neuropathologica 126(5): 659-70, 2013 Notes: #Dr. Xie is a co-first author.

Papay, K., Xie, S.X., Stern, M., Hurtig, H., Siderowf, A., Duda, J.E., Minger, J., Weintraub, D.: Naltrexone for impulse control disorders in Parkinson’s disease: a placebo-controlled study. Neurology 83(9): 826-33, 2014.

Mao, J.J., Farrar, J.T., Bruner, D., Zee, J., Bowman, M., Seluzicki, C., DeMichele, A., Xie, S.X. : Electro-acupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial. Cancer 120(23): 3744-51, 2014.

*Zee, J., Xie, S.X.: Nonparametric discrete survival function estimation with uncertain endpoints using an internal validation subsample. Biometrics 71(3): 772-81, 2015 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor. This paper earned Dr. J. Zee a 2014 Student Travel Award from the Biometrics Section of the American Statistical Association.

*Zee, J., Xie, S.X.; for the Alzheimer's Disease Neuroimaging Initiative: Assessing treatment effects with surrogate survival outcomes using an internal validation subsample. Clinical Trials 12(4): 333-41, 2015 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.

*Zee J, Xie SX: The Kaplan-Meier Method for Estimating and Comparing Proportions in a Randomized Controlled Trial with Dropouts. Biostatistics & Epidemiology 2(1): 23-33, 2018 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.

*Rennert, L., Xie, S.X.: Cox regression model with doubly truncated data. Biometrics 74(2): 725-733, Jun 2018 Notes: *first author is a biostatistics doctoral student to whom I served as the dissertation advisor. This paper earned Mr. Rennert the W. Edwards Deming Student Scholar Award from the 2017 Annual Deming Conference on Applied Statistics.

*Rennert, L., Xie, S.X.: Bias induced by ignoring double truncation inherent in autopsy-confirmed survival studies of neurodegenerative diseases. Statistics in Medicine 38(19): 3599-3613, Aug 2019 Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.

*Rennert L, Xie SX.: Cox regression model under dependent truncation. Biometrics 2021 (in press) Notes: *first author was a biostatistics doctoral student to whom I served as the dissertation advisor.

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Last updated: 07/16/2023
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