Claire H. Mitchell, Ph.D.

faculty photo
Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology
Graduate Group Affiliations

Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Lab: chm@upenn.edu
Education:
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Single Ion Channels )
Institute of Ophthalmology, University College London, U.K., 1994.
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Description of Research Expertise

My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.

Selected Publications

Li, Ziqing, Liu, Tongjun, Gilmore, Alyssa, Gómez, Néstor Más, Fu, Chuanyun, Lim, Jormay, Yang, Shuting, Mitchell, Claire H, Li, Yi-ping, Oursler, Merry J, Yang, Shuying: Regulator of G protein signaling protein 12 (Rgs12) controls mouse osteoblast differentiation via calcium channel/oscillation and Gαi-ERK signaling. Journal of Bone and Mineral Research(ja), 2019.

Ventura, Ana Lucia Marques, dos Santos-Rodrigues, Alexandre, Mitchell, Claire H., Faillace, Maria Paula: Purinergic signaling in the retina: From development to disease. Brain Research Bulletin 2018.

Albalawi, F., Lim, J. C., DiRenzo, K. V., Hersh, E. V., Mitchell, C. H.: Effects of Lidocaine and Articaine on Neuronal Survival and Recovery. Anesth Prog 65(2): 82-88, 2018.

Beckel, J. M., Gomez, N. M., Lu, W., Campagno, K. E., Nabet, B., Albalawi, F., Lim, J. C., Boesze-Battaglia, K., Mitchell, C. H.: Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels. Sci Rep 8(1): 5726. 2018.

Gómez NM, , Lu W,, Lim, JC,, Kiselyov, K,, Grishchuk, Y,, Slaugenhaupt, SA,, Pfeffer B,, Fliesler SJ, , Mitchell CH. : Robust lysosomal calcium signaling through channel TRPML1 is impaired by lipofuscin accumulation Faseb J 32(2): 782-794 2018.

Lu, Wennan, Gómez, Néstor Más, Lim, Jason C., Guha, Sonia, Campagno, Keith E., McCaughey, Stuart A, Laties, Alan M., Carlsson, Leif G., Mitchell, Claire H.: The P2Y12 receptor antagonist ticagrelor reduces lysosomal pH and autofluorescence in retinal pigmented epithelial cells from the ABCA4-/- mouse model of retinal degeneration. Frontiers in Pharmacology-Experimental Pharmacology and Drug Discovery 9: 242, 2018.

Ma, Zhongming, Taruno, Akiyuki, Ohmoto, Makoto, Jyotaki, Masafumi, Lim, Jason C., Miyazaki, Hiroaki, Niisato, Naomi, Marunaka, Yoshinori, Lee, Robert J., Hoff, Henry, Payne, Riley, Demuro, Angelo, Parker, Ian, Mitchell, Claire H., Henao-Mejia, Jorge, Tanis, Jessica E., Matsumoto, Ichiro, Tordoff, Michael G., Foskett, J. Kevin: CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes. Neuron 98(3): 547-561.e10, 2018.

Ramachandra Rao, Sriganesh, Pfeffer, Bruce A., Más Gómez, Néstor, Skelton, Lara A., Keiko, Ueda, Sparrow, Janet R., Rowsam, Aryn M., Mitchell, Claire H., Fliesler, Steven J.: Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome. Autophagy. Taylor & Francis, 14(10): 1796-1817, 2018.

Workman, A. D., Carey, R. M., Chen, B., Saunders, C. J., Marambaud, P., Mitchell, C. H., Tordoff, M. G., Lee, R. J., Cohen, N. A.: CALHM1-Mediated ATP release and ciliary beat frequency modulation in nasal epithelial cells. Sci Rep 7(1): 6687. 2017.

Tamm, Ernst R., Ethier, C. Ross, Dowling, John E., Downs, Crawford, Ellisman, Mark H., Fisher, Steven, Fortune, Brad, Fruttiger, Marcus, Jakobs, Tatjana, Lewis, Geoffrey, Masland, Richard H., Mitchell, Claire H., Morrison, John, Sharma, Sansar C., Sigal, Ian, Sofroniew, Michael, Wang, Lin, Wiggs, Janey, Wu, Samuel: Biological aspects of axonal damage in glaucoma: A brief review. Exp Eye Res 157: 5-12, 2017.

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Last updated: 03/31/2019
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