Edward J. (Jim) Delikatny, Ph.D.

faculty photo
Research Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania,
Department of Radiology,
317 Anatomy Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-3105
B.Sc. (Chemistry/Environmental Studies)
University of Winnipeg, 1978.
Ph.D. (Physical Chemistry)
University of British Columbia, 1987.
Permanent link
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Description of Research Expertise

Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.

Description of Other Expertise

MR spectroscopy, MR imaging, NIR optical imaging, Cerenkov imaging, contrast agent design, anticancer drugs, lipid metabolism, cancer pharmacology

Selected Publications

Azari, F., Kennedy, G., Zhang, K., Bernstein, E., Chang, A., Nadeem, B., Segil, A., Desphande, C., Delikatny, J., Kucharczuk, J., and Singhal, S.: Effects of light-absorbing carbons in intraoperative molecular imaging-guided lung cancer resections. Molecular Imaging and Biology (in press) 2022 Notes: 10.1007/s11307-021-01699-6. Advance online publication. https://doi.org/10.1007/s11307-021-01699-6.

Kennedy G.T., Holt D., Azari F.S., Bernstein E., Nadeem B., Chang A., Sullivan N.T., Segil A., Deshpande C., Bensen E., Santini, Jr J.T., Kucharczuk J.C., Delikatny E.J., Bogyo M., Egan A.J.M., Bradley C.W., Eruslanov E., Lickliter J.D., Wright G. and Singhal S. : A cathepsin targeted quenched activity-based probe facilitates enhanced detection of human tumors during resection. Clinical Cancer Research (in press) 2022.

Kennedy G.T., Azari F.S., Nadeem B., Chang A., Segil A., Bernstein E., Deshpande C., Kucharczuk J.C., Delikatny E.J. and Singhal S. : Preclinical evaluation of a novel quenched activity-based near-infrared probe for intraoperative molecular imaging of esophageal cancer. Molecular Imaging (in press) 2022.

Azari F.S., Kennedy G.T., Chang A., Nadeem B., Segil A., Bernstein E., Sullivan N.T., Eruslanov E., Delikatny E.J. and Singhal S.: Sodium multivitamin transporter-targeted fluorochrome facilitates enhanced metabolic evaluation of tumors through Coenzyme-R dependent intracellular signaling pathways. European Journal of Nuclear Medicine and Molecular Imaging (in press) 2022.

Rubtsova, N.I., Hart, M.C., Arroyo, A.D., Osharovich, S.A., Liebov, B.K., Miller, J., Yuan, M., Cochran, J.M., Chong, S., Yodh, A.G., Busch, T.M., Delikatny, E.J., Anikeeva, N., and Popov, A.V. : NIR fluorescent imaging and photodynamic therapy with a novel theranostic phospholipid probe for triple-negative breast cancer cells. Bioconjugate Chemistry 18(32): 1852-1863, Aug 2021 Notes: doi:10.1021/acs.bioconjchem.1c00295.

Bryski, M.G., Frenzel-Sulyok, L.G., Delikatny, E.J., Deshpande, C., Litzky, L.A., and Singhal, S.. : Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation. PLoS One 16(6): e0252731, Jun 2021.

Azari, F., Kennedy, G., Bernstein, E., Delikatny, E.J., Lee, J., Kucharczuk, J., Low, P.S., and Singhal, S.: Evaluation of OTL38-generated tumor-to-background ratio in intraoperative molecular imaging-guided lung cancer resections. Molecular imaging and Biology Jun 2021 Notes: https://doi.org/10.1007/s11307-021-01618-9.

Teng, C.W., Cho, S.S., Singh, Y., De Ravin, E., Somers, K., Buch, L., Brem, S., Singhal, S., Delikatny, E.J., and Lee, J. : Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery. Journal of Neurosurgery 2: 1-10, Mar 2021 Notes: https://doi.org/10.3171/2020.8.JNS201810.

Kennedy, G. T., Azari, F. S., Bernstein, E., Desphande, C., Din, A., Marfatia, I., Kucharczuk, J. C., Delikatny, E. J., Low, P. S., and Singhal, S. : 3D Specimen Mapping Expedites Frozen Section Diagnosis of Nonpalpable Ground Glass Opacities. The Annals of Thoracic Surgery S0003-4975(21): 01848-8, 2021 Notes: Advance online publication. https://doi.org/10.1016/j.athoracsur.2021.09.069.

Cho SS, Sheikh S, Teng CW, Georges J, Yang AI, De Ravin E, Buch L, Li C, Singh Y, Appelt D, Delikatny EJ, Petersson EJ, Tsourkas A, Dorsey J, Singhal S, Lee JYK : Evaluation of diagnostic accuracy following the coadministration of Delta-Aminolevulinic Acid and second window indocyanine green in rodent and human glioblastomas. Molecular Imaging and Biology Page: 1266-1279, Oct 2020 Notes: https://doi.org/10.1007/s11307-020-01504-w.

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Last updated: 07/19/2022
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