Faculty

Beatriz M. Carreno, PhD

Research Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

PCAM South Tower, 8th Floor
3400 Civic Blvd
Philadelphia, PA 19104

Office: 215-573-7044
Lab: 215-573-4931

Email:
bcarreno@upenn.edu

Publications

Search PubMed for articles

Education:
BS
Universidad Simon Bolivar, Caracas, Venezuela, 1981.
PhD (Microbiology)
Georgetown University School of Medicine, 1989.

Links
Search PubMed for articles
University of Pennsylvania, Center for Cellular Immunotherapies site

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Bear, A.S., Nadler, R.B., O'Hara, M.H., Stanton, K.L., Xu, C., Saporito, R.J., Rech, A.J., Baroja, M.L., Blanchard, T., Elliott, M.H., Ford, M.J., Jones, R.C., Patel, S., Brennan, A.L., O'Neil, Z.O., Powell Jr., D.J., Vonderheide, R.H., Linette, G.P., Carreno, B.M.: Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors. J Clin Invest Sept 2024 Notes: Online ahead of print.

Patel, R.P., Ghilardi, G., Zhang, Y., Chiang, Y., Xie, W., Guruprasad, P., Kim, K., Chun, I., Angelos, M.G., Pajarillo, R., Hong, S., Lee, Y., Shestova, O., Shaw, C., Cohen, I., Gupta, A., Vu, T., Qian, D., Yang, S., Nimmagadda, A., Snook, A.E., Siciliano, N., Rotolo, A., Inamdar, A., Harris, J., Ugwuanyi, O., Wang, M., Carturan, A., Paruzzo, L., Chen, L., Ballard, H.J., Blanchard, T., Xu, C., Abdel-Mohsen, M., Gabunia, K., Wysocka, M., Linette, G.P., Carreno, B.M., Barrett, D.M., Teachey, D.T., Posey, A.D., Powell Jr., D.J., Sauter, C.T., Pileri, S., Pillai, V., Scholler, J., Rook, A.H., Schuster, S.J., Barta, S.K., Porazzi, P., Ruella, M.: CD5 deletion enhances the antitumor activity of adoptive T cell therapies. Sci Immunol 9(97): eadn6509, Jul 2024.

Linette GP, Bear AS, Carreno BM: Facts and hopes in immunotherapy strategies targeting antigens derived from KRAS mutations. Clin Cancer Res Jan 2024 Notes: doi: 10.1158/1078-0432.CCR-23-1212. Online ahead of print.

Lee IK, Sharma N, Noguera-Ortega E, Liousia M, Baroja ML, Etersque JM, Pham J, Sarkar S, Carreno BM, Linette GP, Puré E, Albelda SM, Sellmyer MA.: A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther 31(12): 3564-3578, Dec 2023.

Garfall AL, Cohen AD, Susanibar-Adaniya SP, Hwang WT, Vogl DT, Waxman AJ, Lacey SF, Gonzalez VE, Fraietta JA, Gupta M, Kulikovskaya I, Tian L, Chen F, Koterba N, Bartoszek RL, Patchin M, Xu R, Plesa G, Siegel DL, Brennan A, Nelson AM, Ferthio R, Cosey A, Shea KM, Leskowitz R, Four M, Wilson WV, Miao F, Lancaster E, Carreno BM, Linette GP, Hexner EO, Young RM, Bu D, Mansfield KG, Brogdon JL, June CH, Milone MC, Stadtmauer EA.: Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy. Blood Cancer Discov 4(2): 118-133, Mar 2023.

Bear, A.S., Nadler, R.B., Scholler, J., Vonderheide, R.H., Linette, G.P., Carreno, B.M.: TCR1020 specific for KRAS G12V restricted to HLA-A*11:01 exhibits potent and precise antigen specificity for clinical development. AACR- Targeting Ras, Philadelphia, PA Mar 2023 Notes: Oral Presentation.

Smole, A., Benton, A., Poussin, M.A., Eiva, M.A., Mezzanotte, C., Camisa, B., Greco, B., Sharma, P., Minutolo, N.G., Gray, F., Bear, A.S., Baroja, M.L., Cummins, C., Xu, C., Sanvito, F., Goldgewicht, A.L., Blanchard, T., Rodriguez-Garcia, A., Klichinsky, M., Bonini, C., June, C.H., Posey, A.D., Linette, G.P., Carreno, B.M., Casucci, M., Powell, D.J.: Expression of inducible factors reprograms CAR-T cells for enhanced function and safety. Cancer Cell 40(12): 1470-1487, Dec 2022.

Apodaca, K., Xu, C., Stanton, K., Carreno, B.M., Linette, G.P.: Determining the Histocompatibility Barriers between Universal CAR T (UCART) cells and NK cells. SITC Annual Meeting 2022, Boston, MA Nov 2022 Notes: Poster Presentation.

Olson, T.S., Frost, B.F., Duke, J.L., Dribus, M., Xie, H.M., Prudowsky, Z.D., Furutani, E., Gudera, J., Shah, Y.B., Ferriola, D., Dinou, A., Pagkrati, I., Kim, S., Xu, Y., He, M., Zheng, S., Nijim, S., Lin, P., Xu, C., Nakano, T., Oved, J.H., Carreno, B.M., Bolon, Y., Gadalla, S.M., Marsh, S.G., Paczesny, S., Lee, S.J., Monos, D.S., Shimamura, A., Bertuch, A.A., Gragert, L., Spellman, S., Babushok, D.V.: Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities. JCI Insight 7(22): e163040, Nov 2022.

Nadler, R.B., Bear, A.S., Saporito, R.J., Scholler, J., Vonderheide, R.H., Linette, G.P., Carreno, B.M. : TCRs directed to mutant KRAS display distinct antigen recognition motifs and minimal cross-reactivity to non-cognate antigens. AACR-Pancreas Cancer Collective Meeting, Boston MA Sept 2022 Notes: Poster Presentation.