Faculty

Amelia J. Eisch, Ph.D.

faculty photo
Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Abramson Research Center, Room 402D
3615 Civic Center Drive
Philadelphia, PA 19104-4399
Office: sites.google.com/view/eischlab
Education:
B.A. (Psychology/Biology)
Yale University, 1990.
Ph.D. (Biological Sciences )
University of California, Irvine, 1997.
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Description of Other Expertise

In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.

Description of Research Expertise

I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).

Selected Publications

Pulido KM, Viaene AN, Eisch AJ, Barber DG: Microglia in Post-Mortem Hippocampal Brain Tissue of Male and Female Neonates after HIE. CHOP's SUMMR Research Colloquium, Philadelphia, PA July 2024.

Classe LP, Babiker NA, Butler SJ, Godfrey-Andrade T, Yun S, Zderic SA, Eisch AJ: Does Urinary Tract Infection Lead to Brain Inflammation in Mice in Early-Life? ITMAT TRIP Symposium, UPenn Perelman School of Medicine, Philadelphia PA July 2024.

Dellinger EG, Babiker NA, Bancroft GL, Yun S, Eisch AJ: Neuronal activity in the entorhinal cortex during different memory loads of similar stimuli discrimination tasks while encoding memories. ITMAT TRIP Symposium, UPenn Perelman School of Medicine, Philadelphia PA July 2024.

Godfrey-Andrade T, Yun S, Zderic SA, Eisch AJ: Early life bladder inflammation induces later life urinating dysfunction, anxiety-, and depressive-like behaviors in mice. The Leadership Alliance National Symposium, Hartford, CT June 2024.

Haas HA, Bancroft GL, Babiker NA, Eisch AJ, Yun S: Subanesthetic ketamine’s antidepressant potential: pilot in vivo recording of neurons in a mouse memory circuit. Annual Philadelphia Chapter of the Society for Neuroscience Meeting, Philadelphia, PA April 2024.

Bancroft GL, Mahajan A, Haas HA, Leland SP, Yun S, Eisch AJ: Navigating Memory Encoding of Similar Information: An Investigation of LEC-DG Circuitry. Annual Philadelphia Chapter of the Society for Neuroscience Meeting April 2024.

Mahajan A, Bancroft GL, Haas HA, Wallen-Friedman E, Vasisht S, Takano H, Kiffer FC, Eisch AJ, Yun S: Real-time measurement of a relevant hippocampal activity during discriminating similar stimuli in mature male mice after exposed to simulated space radiation. Annual Philadelphia Chapter of the Society for Neuroscience Meeting, Philadelphia, PA April 2024.

Leland SL, Noh H, Wallen-Friedman E, Bancroft GL, Vasisht S, Narain PK, Mahajan A, Goldberg EM, Eisch AJ, Yun S: Investigating Dentate Gyrus Cell Proliferation in a Sex-dependent Manner in a Translational Mouse Model: Implications for Assessing Dravet Syndrome Pathophysiology. Annual Philadelphia Chapter of the Society for Neuroscience Meeting, Philadelphia, PA April 2024.

Kiffer FC, Mahajan AI, Bancroft GL, Haas HA, Wallen-Friedman E, Vasisht S, Takano H, Eisch AJ, Yun S: Real-time measurement of hippocampal dentate gyrus activity during pattern separation in male mice exposed to 33-particle galactic cosmic radiation (33-GCR). Human Research Program: Investigator's Workshop, Frontiers in Human Space Exploration Research​, Galveston, TX February 2024.

Yun S*^, Kiffer FC*, Bancroft GL@, Guzman CS@, Soler IS@, Haas HA, Shi R, Patel R, Lara-Jiménez J, Kumar PL, Tran FH, Ahn KJ, Rong Y, Luitel K, Shay JW, Eisch AJ^ *equal contribution, @equal contribution, ^co-corresponding authors: The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures Journal of Neurochemistry special issue "Touchscreen Testing to Investigate the Neurochemistry of Cognition" 2024.

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Last updated: 08/07/2024
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