Klaus Hopster, DVM, PhD

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Graduate Group Affiliations

Contact information
University of Pennsylvania
School of Veterinary Medicine
Department of Clinical Studies-NBC
382 West Street Road
Kennett Square, PA 19348
Office: 6109256601
Fax: 6109256820
Lab: 6109256125
DMV (Veterinary Medicine)
University of Veterinary Medicine Hannover, 2006.
DrMedVet (Veterinary Medicine)
School of Veterinary Medicine Hannover, 2007.
PhD (Microperfusion and oxygenation of the gastrointestinal tract in anesthetitized horses)
The University of Veterinary Medicine Hannover, Germany, 2019.
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Description of Research Expertise

Peripheral tissue oxygenation during anesthesia in horses, focusing on establishment of new ventilation modes to improve the oxygen uptake during anesthesia with no to minimal interaction with the cardiovascular system

Pain assessment and management in horses

New modalities of locoregional anesthesia and analgesia

Selected Publications

Adler, D. M. T., Hopster, K., Hopster-Iversen, C., Fenner, M., Buhl, R., Jacobsen, S.: Thoracotomy and Pericardiotomy for Access to the Heart in Horses: Surgical Procedure and Effects on Anesthetic Variables. J Equine Vet Sci 96: 103315, 2021.

VanderBroek, A. R., Engiles, J. B., Kästner, S. B. R., Kopp, V., Verhaar, N., Hopster, K.: Protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in horses. Equine Vet J 53(3): 569-578, 2021.

Hurcombe, S. D., Klein, C. E., Roessner, H. A., Engiles, J. B., Hopster, K.: Use of polyamide cable ties during experimental omentectomy in adult horses with histopathological assessment. Vet Surg 2021.

Floriano, D. A., Hopster, K., Broek, A. R. V., Reef, V. B., Slack, J.: Anesthesia Case of the Month. J Am Vet Med Assoc 258(12): 1341-1344, 2021.

Arndt, S., Hopster, K., Sill, V., Rohn, K., Kästner, S. B. R.: Comparison between head-tail-rope assisted and unassisted recoveries in healthy horses undergoing general anesthesia for elective surgeries. Vet Surg 49(2): 329-338, 2020.

Luethy, D., Hopster, K.: Electrolyte measurement in goats: Comparison of 2 blood gas analyzers and evaluation of the preanalytical blood sample preparation on measurement results. Tierarztl Prax Ausg G Grosstiere Nutztiere 48(3): 148-155, 2020.

König, K. S., Verhaar, N., Hopster, K., Pfarrer, C., Neudeck, S., Rohn, K., Kästner, S. B. R.: Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion. PLoS ONE 15(4): e0224720, 2020.

Hurcombe, S. D., Morris, T. B., VanderBroek, A. R., Habecker, P., Wulster, K., Hopster, K.: Cervical Epidural and Subarachnoid Catheter Placement in Standing Adult Horses. Front Vet Sci 7: 232, 2020.

Hopster, K., Soma, L. R., Li, X., Hopster-Iversen, C., Boston, R. C., Driessen, B.: Pharmacokinetics of xylazine after 2-, 4-, and 6-hr durations of continuous rate infusions in horses. J Vet Pharmacol Ther 43(6): 557-564, 2020.

Gaesser, A. M., Varner, K. M., Douglas, H. F., Barr, C. A., Hopster, K., Levine, D. G.: The effect of intra-articular mepivacaine administration prior to carpal arthroscopy on anesthesia management and recovery characteristics in horses. Vet Surg 49(7): 1343-1349, 2020.

Floriano, D., Hopster, K., Driessen, B.: Accuracy of tidal volume delivery by five different models of large-animal ventilators. Am J Vet Res 81(11): 857-864, 2020.

Douglas, H., Hopster, K., Cerullo, M., Hopster-Iversen, C., Stefanovski, D., Driessen, B.: The effects of flumazenil on ventilatory and recovery characteristics in horses following midazolam-ketamine induction and isoflurane anaesthesia. Equine Vet J 2020.

Crandall, A., Hopster, K., Grove, A., Levine, D.: Intratesticular mepivacaine versus lidocaine in anaesthetised horses undergoing Henderson castration. Equine Vet J 52(6): 805-810, 2020.

Cerullo, M., Driessen, B., Douglas, H., Hopster, K.: Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses. Front Vet Sci 7: 601326, 2020.

Echelmeyer, J., Taylor, P. M., Hopster, K., Rohn, K., Delarocque, J., Kästner, S. B. R.: Effect of fentanyl on thermal and mechanical nociceptive thresholds in horses and estimation of anti-nociceptive plasma concentration. Vet J 249: 82-88, 2019.

Varner, K. M., Hopster, K., Driessen, B.: Comparison of various types of inert gas components on efficacy of an alveolar recruitment maneuver in dorsally recumbent anesthetized horses. Am J Vet Res 80(7): 631-636, 2019.

Hopster, K., Bertone, C., Driessen, B.: Evaluation of the effects of gas volume and composition on accuracy of volume measurement by two flow sensors and delivery by a piston-driven large-animal ventilator. Am J Vet Res 80(2): 135-143, 2019.

Dancker, C., Hopster, K., Rohn, K., Kästner, S. B.: Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses. Equine Vet J 50(1): 104-110, 2018.

Wittenberg-Voges, L., Kästner, S. B., Raekallio, M., Vainio, O. M., Rohn, K., Hopster, K.: Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses. Vet Anaesth Analg 45(2): 165-174, 2018.

Reiners, J. K., Rossdeutscher, W., Hopster, K., Kästner, S. B. R.: Development and clinical evaluation of a new sensor design for buccal pulse oximetry in horses. Equine Vet J 50(2): 228-234, 2018.

Neudeck, S., Kästner, S. B. R., Wittenberg-Voges, L., Rohn, K., Hopster, K.: Comparison of desflurane and propofol at equipotent doses in combination with a constant rate infusion of dexmedetomidine on global and peripheral perfusion and oxygenation in horses. Am J Vet Res 79(5): 487-495, 2018.

Hopster, K., Neudeck, S., Wittenberg-Voges, L., Kästner, S. B.: The relationship between intestinal and oral mucosa microcirculation in anaesthetized horses. Vet Anaesth Analg 45(1): 78-81, 2018.

Hopster, K., Duffee, L. R., Hopster-Iversen, C. C. S., Driessen, B.: Efficacy of an alveolar recruitment maneuver for improving gas exchange and pulmonary mechanics in anesthetized horses ventilated with oxygen or a helium-oxygen mixture. Am J Vet Res 79(10): 1021-1027, 2018.

Hopster K, Wittenberg-Voges L, Geburek F, Hopster-Iversen C, Kästner SBR : Effects of controlled hypoxemia or hypovolemia on global and intestinal oxygenation and perfusion in anesthetized horses. BMC Vet Res 28;13(1): 361, November 2017 Notes: doi: 10.1186/s12917-017-1265-3.

Yavari, S., Khraim, N., Szura, G., Starke, A., Engelke, E., Pfarrer, C., Hopster, K., Schmicke, M., Kehler, W., Heppelmann, M., Kästner, S. B. R., Rehage, J.: Evaluation of intravenous regional anaesthesia and four-point nerve block efficacy in the distal hind limb of dairy cows. BMC Vet Res 13(1): 320, 2017.

Müller, T. M., Hopster, K., Bienert-Zeit, A., Rohn, K., Kästner, S. B. R.: Effect of butorphanol, midazolam or ketamine on romifidine based sedation in horses during standing cheek tooth removal. BMC Vet Res 13(1): 381, 2017.

Hopster, K., Wittenberg-Voges, L., Kästner, S. B. R.: Xylazine infusion in isoflurane-anesthetized and ventilated healthy horses: Effects on cardiovascular parameters and intestinal perfusion. Can J Vet Res 81(4): 249-254, 2017.

Hopster, K., Ambrisko, T. D., Kästner, S. B. R.: Influence of catecholamines at different dosages on the function of the LiDCO sensor in isoflurane anesthetized horses. J Vet Emerg Crit Care (San Antonio) 27(6): 651-657, 2017.

Dönselmann Im Sande, P., Hopster, K., Kästner, S.: [Effects of morphine, butorphanol and levomethadone in different doses on thermal nociceptive thresholds in horses] Tierarztl Prax Ausg G Grosstiere Nutztiere 45(2): 98-106, 2017.

Ambrisko, T. D., Schramel, J., Hopster, K., Kästner, S., Moens, Y.: Assessment of distribution of ventilation and regional lung compliance by electrical impedance tomography in anaesthetized horses undergoing alveolar recruitment manoeuvres. Vet Anaesth Analg 44(2): 264-272, 2017.

Hopster K, Ambrisko TD, Kästner SBR : Influence of catecholamines at different dosages on the function of the LiDCO sensor in isoflurane anesthetized horses. J Vet Emerg Crit Care (San Antonio) Page: 24, October 2017 Notes: doi: 10.1111/vec.12672.

Hopster, K., Jacobson, B., Hopster-Iversen, C., Rohn, K., Kästner, S. B.: Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies. Res Vet Sci 107: 8-15, 2016.

Tünsmeyer, J., Hopster, K., Kästner, S. B.: Clinical Use of a Multivariate Electroencephalogram (Narcotrend) for Assessment of Anesthetic Depth in Horses during Isoflurane-Xylazine Anesthesia. Front Vet Sci 3: 25, 2016.

Rieder, C. M., Staszyk, C., Hopster, K., Feige, K., Bienert-Zeit, A.: Maxillary nerve block within the equine pterygopalatine fossa with different volumes: practicability, efficacy and side-effects. Pferdeheilkunde 32(2): 132-140, 2016.

Hopster, K., Wogatzki, A., Conze, P., Kästner, S. B.: Effects of positive end-expiratory pressure titration on intestinal oxygenation and perfusion in isoflurane anaesthetised horses. Equine Vet J 2016.

Hopster, K., Rohn, K., Ohnesorge, B., Kästner, S. B.: Controlled mechanical ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvres during anaesthesia in laterally or dorsally recumbent horses. Vet Anaesth Analg 2016.

Hopster, K., Ambrisko, T. D., Stahl, J., Schramel, J. P., Kästner, S. B.: Influence of xylazine on the function of the LiDCO sensor in isoflurane anaesthetized horses. Vet Anaesth Analg 42(2): 142-149, 2015.

Tünsmeyer, J., Hopster, K., Feige, K., Kästner, S. B.: Agreement of high definition oscillometry with direct arterial blood pressure measurement at different blood pressure ranges in horses under general anaesthesia. Vet Anaesth Analg 42(3): 286-291, 2015.

Pöppel, N., Hopster, K., Geburek, F., Kästner, S.: Influence of ketamine or xylazine supplementation on isoflurane anaesthetized horses--a controlled clinical trial. Vet Anaesth Analg 42(1): 30-38, 2015.

Hopster, K., Hopster-Iversen, C., Geburek, F., Rohn, K., Kästner, S. B.: Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses. Vet J 205(1): 62-68, 2015.

Conze, P., van Schie, H. T., van Weeren, R., Staszyk, C., Conrad, S., Skutella, T., Hopster, K., Rohn, K., Stadler, P., Geburek, F.: Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions. Regen Med 9(6): 743-757, 2014.

Reichert, C., Kästner, S. B., Hopster, K., Rohn, K., Rötting, A. K.: Use of micro-lightguide spectrophotometry for evaluation of microcirculation in the small and large intestines of horses without gastrointestinal disease. Am J Vet Res 75(11): 990-996, 2014.

Hopster-Iversen, C. C., Hopster, K., Staszyk, C., Rohn, K., Freeman, D. E., Rötting, A. K.: Effects of experimental mechanical manipulations on local inflammation in the jejunum of horses. Am J Vet Res 75(4): 385-391, 2014.

Hopster, K., Müller, C., Hopster-Iversen, C., Stahl, J., Rohn, K., Kästner, S.: Effects of dexmedetomidine and xylazine on cardiovascular function during total intravenous anaesthesia with midazolam and ketamine and recovery quality and duration in horses. Vet Anaesth Analg 41(1): 25-35, 2014.

Gozalo-Marcilla, M., Hopster, K., Gasthuys, F., Krajewski, A. E., Schwarz, A., Schauvliege, S.: Minimum end-tidal sevoflurane concentration necessary to prevent movement during a constant rate infusion of morphine, or morphine plus dexmedetomidine in ponies. Vet Anaesth Analg 41(2): 212-219, 2014.

Gozalo-Marcilla, M., Hopster, K., Gasthuys, F., Hatz, L., Krajewski, A. E., Schauvliege, S.: Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies. Equine Vet J 45(2): 204-208, 2013.

Tappenbeck, K., Hoppe, S., Hopster, K., Kietzmann, M., Feige, K., Huber, K.: Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia-reperfusion injured equine intestinal smooth muscle in vitro. Vet J 196(3): 461-466, 2013.

Poller, C., Hopster, K., Rohn, K., Kästner, S. B.: Evaluation of contact heat thermal threshold testing for standardized assessment of cutaneous nociception in horses - comparison of different locations and environmental conditions. BMC Vet Res 9: 4, 2013.

Poller, C., Hopster, K., Rohn, K., Kästner, S. B.: Nociceptive thermal threshold testing in horses - effect of neuroleptic sedation and neuroleptanalgesia at different stimulation sites. BMC Vet Res 9: 135, 2013.

Hopster, K., Bienert-Zeit, A., Hopster-Iversen, C., Kästner, S. B. R.: Influence of ketamine or midazolam in combination with a romifidine-butorphanol-constant rate infusion on sedation quality during tooth extraction in standing horses. Pferdeheilkunde 29(2): 220-227, 2013.

Hopster, K., Ohnesorge, B., von Borstel, M., Rohn, K., Kästner, S.: [Influence of atracurium on cardiovascular parameters in horses undergoing vitrectomy during general anaesthesia, and on recovery duration and quality] Tierarztl Prax Ausg G Grosstiere Nutztiere 41(6): 371-377, 2013.

Müller, C., Hopster, K., Hopster-lversen, C., Rohn, K., Kästner, S. B. R.: Elaboration of a xylazine and dexmedetomidine infusion regime which provides a constant level of sedation in horses. Pferdeheilkunde 28(6): 668-674, 2012.

Tappenbeck, K., Hoppe, S., Hopster, K., Kietzmann, M., Feige, K., Huber, K.: Influence of structural and lipophilic characteristics of lidocaine on its prokinetic effect in intestinal smooth muscle. Journal Of Veterinary Pharmacology And Therapeutics 35: 145-146, 2012.

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Last updated: 06/14/2023
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