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  • Faculty
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  • Akhilesh Basi Reddy
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Faculty

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Akhilesh Basi Reddy, MA MB BChir PhD

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Professor of Systems Pharmacology and Translational Therapeutics
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Department: Systems Pharmacology and Translational Therapeutics
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1f Graduate Group Affiliations 8 a
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46 Contact information
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10-125 Smilow Center for Translational Research
Philadelphia, PA 19104
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Email: akhilesh.reddy@pennmedicine.upenn.edu
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13 Education:
21 7 BA 24 (Medical Sciences Tripos) c
34 University of Cambridge, UK, 1998.
 21 d MB BChir c
34 University of Cambridge, UK, 2003.
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4b MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
 21 7 MA c
34 University of Cambridge, UK, 2012.
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Links
58 Laboratory web site
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Description of Clinical Expertise

21 General Neurology
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Description of Research Expertise

b9 Circadian clocks, Sleep, Metabolism, Neural circuits, Deep Learning, Machine Intelligence, Digital Biology, Programmable Biology, Large language models (LLMs), AI safety
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Selected Publications

136 O'Neill, J. S. and A. B. Reddy*: Circadian clocks in human red blood cells. Nature 469(7331): 498-503, 2011 Notes: *Senior author. Also covered by News & Views editorial by Bass & Takehashi in the same issue, Nature 469:476–478 (2011).

 167 O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011 Notes: *Joint senior author. My lab performed the molecular biology aspects.

 186 Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012 Notes: *Senior author.

 125 Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA 113(36): 10085-90, 2016.

 129 Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.

 1c2 Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nature Communications 8(1): 1978, 2017 Notes: Provided funding, experimental design input and reagents.

 130 Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.

 162 Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, and Akhilesh B. Reddy: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells 3b Nature Communications 12(1), 2021.

 7a Pawan K Jha, Utham K Valekunja, Sandipan Ray, Mathieu Nollet, Akhilesh B Reddy a8 : Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Communications Biology 5(1): 846, 2022.

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