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Douglas H. Smith, MD

Robert A. Groff Professor of Teaching and Research in Neurosurgery
Member , Mental Retardation Research Center, University of Pennsylvania
Member , Institute of Medicine and Engineering, University of Pennsylvania
Member , Functional Imaging Center, University of Pennsylvania
Director , Center for Brain Injury and Repair, University of Pennsylvania
Vice Chairman, Teaching and Research, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania
Department: Neurosurgery

Contact information
105 Hayden Hall
3320 Smith Walk
Philadelphia, PA 19104-6316
Office: 215-573-3156
Fax: 215-573-3808
B.S. (Biology)
University of Connecticut, 1981.
M.D. (Medicine)
University of Noreste, 1986.
Post-Graduate Training
Postdoctoral Fellow in Molecular Biology and Protein Chemistry, University of Connecticut Health Center, 1986-1988.
Postdoctoral Fellow in Neuropharmacology and Trauma, University of Connecticut Health Center, 1989-1990.
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Description of Research Expertise

Douglas H. Smith, MD is Director of the Center for Brain Injury and Repair (CBIR) and Professor of Neurosurgery at the Perelman School of Medicine. CBIR is renowned as a multi-disciplined collaborative bringing together over twenty-five principal investigators and their laboratory staffs whose work studies the mechanisms, diagnosis and potential treatments of traumatic brain injury. Dr. Smith's group has established that diffuse axonal injury (DAI) is a key pathological feature of concussion and that the extent of acute axonal pathology is predictive of cognitive outcome. In addition, his team has discovered mechanisms of concussion and more severe TBI that lead to progressive neurodegeneration such as chronic traumatic encephalopathy. These collective efforts are represented in over 250 published scientific reports with an h-index of over 80.

Dr. Smith directs an NIH training grant for brain injury. He currently serves as the Scientific Director of the Big 10-Ivy League Consortium on Concussion. Dr. Smith also serves on the Scientific Advisory Boards for the US National Football League (NFL), the National Collegiate Athletic Association (NCAA)-DoD Grand Alliance, “Concussion Assessment, Research and Education” (CARE) Consortium and the International Concussion Society.

Selected Publications

Chen H Isaac, Jgamadze Dennis, Lim James, Mensah-Brown Kobina, Wolf John A, Mills Jason A, Smith Douglas H: Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons. Tissue engineering. Part A 25(9-10): 736-745, May 2019.

Gan Zoe S, Stein Sherman C, Swanson Randel, Guan Shaobo, Garcia Lizette, Mehta Devanshi, Smith Douglas H: Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy. Frontiers in neurology 10: 446, Apr 2019.

Stewart William, Allinson Kieren, Al-Sarraj Safa, Bachmeier Corbin, Barlow Karen, Belli Antonio, Burns Mark P, Carson Alan, Crawford Fiona, Dams-O'Connor Kristen, Diaz-Arrastia Ramon, Dixon C Edward, Edlow Brian L, Ferguson Scott, Fischl Bruce, Folkerth Rebecca D, Gentleman Steve, Giza Christopher C, Grady M Sean, Helmy Adel, Herceg Mark, Holton Janice L, Howell David, Hutchinson Peter J, Iacono Diego, Iglesias Juan E, Ikonomovic Milos D, Johnson Victoria E, Keene C Dirk, Kofler Julia K, Koliatsos Vassilis E, Lee Edward B, Levin Harvey, Lifshitz Jonathan, Ling Helen, Loane David J, Love Seth, Maas Andrew Ir, Marklund Niklas, Master Christina L, McElvenny Damien M, Meaney David F, Menon David K, Montine Thomas J, Mouzon Benoit, Mufson Elliott J, Ojo Joseph O, Prins Mayumi, Revesz Tamas, Ritchie Craig W, Smith Colin, Sylvester Richard, Tang Cheuk Y, Trojanowski John Q, Urankar Kathryn, Vink Robert, Wellington Cheryl, Wilde Elisabeth A, Wilson Lindsay, Yeates Keith, Smith Douglas H: Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology 18(3): 231-233, Mar 2019.

Smith Douglas H, Johnson Victoria E, Trojanowski John Q, Stewart William: Chronic traumatic encephalopathy - confusion and controversies. Nature reviews. Neurology 15(3): 179-183, Mar 2019.

Dollé Jean-Pierre, Jaye Andrew, Anderson Stewart A, Ahmadzadeh Hossein, Shenoy Vivek B, Smith Douglas H: Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury. Experimental neurology 300: 121-134, Feb 2018.

Johnson Victoria E, Weber Maura T, Xiao Rui, Cullen D Kacy, Meaney David F, Stewart William, Smith Douglas H: Mechanical disruption of the blood-brain barrier following experimental concussion. Acta neuropathologica 135(5): 711-726, May 2018.

Dollé Jean-Pierre, Rodgers Jeffrey M, Browne Kevin D, Troxler Thomas, Gai Feng, Smith Douglas H: Newfound effect of N-acetylaspartate in preventing and reversing aggregation of amyloid-beta in vitro. Neurobiology of disease 117: 161-169, Sep 2018.

Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network. J Neural Eng 14(2), April 2017.

Johnson Victoria E, Stewart William, Weber Maura T, Cullen D Kacy, Siman Robert, Smith Douglas H: SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury. Acta neuropathologica 131(1): 115-35, Jan 2016.

Smith Douglas H, Stewart William: Tackling concussion, beyond Hollywood. The Lancet. Neurology 15(7): 662-3, Jun 2016.

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Last updated: 11/04/2019
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