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Steven Brem, M.D.

Professor CE of Neurosurgery
Director, Medical Student Education, Department of Neurosurgery, University of Pennsylvania
Medical Director, Center for Precision Surgery, Abramson Cancer Center, Perelman School of Medicine,
Senior Member, Neuro-Oncology Leadership Group, Abramson Cancer Center Perelman School of Medicine University of Pennsylvania
Member, Clinical Trials Scientific Review Monitoring Committee, Abramson Cancer Center
Department: Neurosurgery

Contact information
Department of Neurosurgery
PCAM South - Room 15-141
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-6130
Fax: 215-349-5534
Lab: n/a
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
Post-Graduate Training
Surgery , Massachusetts General Hospital - Intership , 1972-1973.
Neurosurgery, Massachusetts General Hospital - Residency , 1973-1981.
Clinical Associate, Oncology, Laboratory of Pathophysiology, National Cancer Institute - Postdoctoral Research, 1974-1976.
Neurosurgery, New York Hospital, Cornell Medical Center - Fellowship , 1979-1980.
Surgical Leadership Program, Harvard Medical School, 2018-2019.
Certifications
National Board of Medical Examiners, 1973.
Royal College of Physicians and Surgeons of Canada, Neurosurgery Fellowship , 1982.
Province of Quebec, Neurosurgery , 1982.
American Board of Neurological Surgery, 1983.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies, Connectomics, IL-6, cytokines, Viral Oncolytics, Vagus Nerve Stimulation

Selected Publications

Brem S, Hoch MJ.: Commentary: Resting State Functional Networks in Gliomas: Validation With Direct Electrical Stimulation Using a New Tool for Planning Brain Resections. Neurosurgery Jun 2024.

Guo J, Fathi Kazerooni A, Toorens E, Akbari H, Yu F, Sako C, Mamourian E, Shinohara RT, Koumenis C, Bagley SJ, Morrissette JJD, Binder ZA, Brem S, Mohan S, Lustig RA, O'Rourke DM, Ganguly T, Bakas S, Nasrallah MP, Davatzikos C.: Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach. Sci Rep 14: 4922, Feb 2024.

Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM.: Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial. Nat Cancer 5: 517-531, January 2024.

Lu Y, Lee J, Li J, Allu SR, Wang J, Kim H, Bullaughey KL, Fisher SA, Nordgren CE, Rosario JG, Anderson SA, Ulyanova AV, Brem S, Chen HI, Wolf JA, Grady MS, Vinogradov SA, Kim J, Eberwine J.: CHEX-seq detects single-cell genomic single-stranded DNA with catalytical potential. Nat Commun 14: 7346, Nov 2023.

de Godoy LL, Chawla S, Brem S, Mohan S.: Taming Glioblastoma in "Real Time": Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology. Clin Cancer Res 29: 2588-2592, Jul 2023.

Richardson TE, Yokoda RT, Rashidipour O, Vij M, Snuderl M, Brem S, Hatanpaa KJ, McBrayer SK, Abdullah KG, Umphlett M, Walker JM, Tsankova NM.: Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma. Neurooncol Adv 5: vdad085, Jul 2023.

Sampson JH, Singh Achrol A, Aghi MK, Bankiewicz K, Bexon M, Brem S, Brenner A, Chandhasin C, Chowdhary S, Coello M, Ellingson BM, Floyd JR, Han S, Kesari S, Mardor Y, Merchant F, Merchant N, Randazzo D, Vogelbaum M, Vrionis F, Wembacher-Schroeder E, Zabek M, Butowski N.: Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial. Neuro Oncol 25: 1085-1097, Jun 2023.

Nabavizadeh A, Bagley SJ, Doot RK, Ware JB, Young AJ, Ghodasara S, Zhao C, Anderson H, Schubert E, Carpenter EL, Till J, Henderson F Jr, Pantel AR, Chen HI, Lee JYK, Amankulor NM, O'Rourke DM, Desai A, Nasrallah MP, Brem S.: Distinguishing Progression from Pseudoprogression in Glioblastoma Using (18)F-Fluciclovine PET. J Nucl Med 64(6), JUNE 2023.

de Godoy LL, Chawla S, Brem S, Wang S, O'Rourke DM, Nasrallah MP, Desai A, Loevner LA, Liau LM, Mohan S.: Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model. J Neurooncol 163(1), May 2023.

Golkar E, Parker D, Brem S, Almairac F, Verma R.: CrOssing fiber Modeling in the Peritumoral Area using dMRI (COMPARI). bioRxiv May 2023.

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Last updated: 07/02/2024
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