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Steven Brem, M.D.

Professor CE of Neurosurgery
Director, Medical Student Education, Department of Neurosurgery, University of Pennsylvania
Medical Director, Center for Precision Surgery, Abramson Cancer Center, Perelman School of Medicine,
Senior Member, Neuro-Oncology Leadership Group, Abramson Cancer Center Perelman School of Medicine University of Pennsylvania
Member, Clinical Trials Scientific Review Monitoring Committee, Abramson Cancer Center
Department: Neurosurgery

Contact information
Department of Neurosurgery
PCAM South - Room 15-141
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 662-6130
Fax: 215-349-5534
Lab: n/a
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
Post-Graduate Training
Surgery , Massachusetts General Hospital - Intership , 1972-1973.
Neurosurgery, Massachusetts General Hospital - Residency , 1973-1981.
Clinical Associate, Oncology, Laboratory of Pathophysiology, National Cancer Institute - Postdoctoral Research, 1974-1976.
Neurosurgery, New York Hospital, Cornell Medical Center - Fellowship , 1979-1980.
Fellow in Stereotactic Radiosurgery, UCLA, 2005-2005.
Surgical Leadership Program, Harvard Medical School, 2018-2019.
Certifications
National Board of Medical Examiners, 1973.
Royal College of Physicians and Surgeons of Canada, Neurosurgery Fellowship , 1982.
Province of Quebec, Neurosurgery , 1982.
American Board of Neurological Surgery, 1983.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies, Connectomics, IL-6, cytokines, Viral Oncolytics, Vagus Nerve Stimulation

Selected Publications

Akbari H, Bakas S, Sako C, Fathi Kazerooni A, Villanueva-Meyer J, Garcia JA, Mamourian E, Liu F, Cao Q, Shinohara RT, Baid U, Getka A, Pati S, Singh A, Calabrese E, Chang S, Rudie J, Sotiras A, LaMontagne P, Marcus DS, Milchenko M, Nazeri A, Balana C, Capellades J, Puig J, Badve C, Barnholtz-Sloan JS, Sloan AE, Vadmal V, Waite K, Ak M, Colen RR, Park YW, Ahn SS, Chang JH, Choi YS, Lee SK, Alexander GS, Ali AS, Dicker AP, Flanders AE, Liem S, Lombardo J, Shi W, Shukla G, Griffith B, Poisson LM, Rogers LR, Kotrotsou A, Booth TC, Jain R, Lee M, Mahajan A, Chakravarti A, Palmer JD, DiCostanzo D, Fathallah-Shaykh H, Cepeda S, Santonocito OS, Di Stefano AL, Wiestler B, Melhem ER, Woodworth GF, Tiwari P, Valdes P, Matsumoto Y, Otani Y, Imoto R, Aboian M, Koizumi S, Kurozumi K, Kawakatsu T, Alexander K, Satgunaseelan L, Rulseh AM, Bagley SJ, Bilello M, Binder ZA, Brem S, Desai AS, Lustig RA, Maloney E, Prior T, Amankulor N, Nasrallah MP, O'Rourke DM, Mohan S, Davatzikos C; ReSPOND consortium.: Machine learning-based prognostic subgrouping of glioblastoma: A multicenter study. Neuro Oncol 27: 1102-1115, May 2025.

Wen PY, Manzanera A, Duault C, Gonzalez-Kozlova E, Lopez L, Grossman SA, Ye X, Fisher J, Lee I, Walbert T, Snyder J, Brem S, Desai A, Bagley SJ, Kakani C, Strowd R, Tatter S, Laxton A, Lesser G, Amankulor N, Lieberman F, Drappatz J, Mantica M, Triggs D, Haymaker C, Wistuba II, Al-Atrash G, Mendoza Perez J, Futreal A, Little LD, Islam MDH, Duose D, Jiang P, Reuben A, Lawler SE, Pichavant M, Gentles A, Bendall S, Kong A, Camacho C, Del Valle D, Kim-Schulze S, Gnjatic S, Sharon E, Nowicki MO, Peruzzi P, Lane D, Aguilar-Cordova E, Aguilar LK, Nichols G, Dwyer J, Tak PP, Maecker H, Barone F, Chiocca EA.: A multi-institutional phase 1 clinical trial exploring upfront multimodal standard of care and combined immunotherapies for newly diagnosed glioblastoma. Neuro Oncol Mar 2025.

de Godoy LL, Rajan A, Banihashemi A, Patel T, Desai A, Bagley S, Brem S, Chawla S, Mohan S.: Response Assessment in Long-Term Glioblastoma Survivors Using a Multiparametric MRI-Based Prediction Model. Brain Sci 15: 146, Jan 2025.

Hosseini SA, Servaes S, Hall B, Bhaduri S, Rajan A, Rosa-Neto P, Brem S, Loevner LA, Mohan S, Chawla S.: Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases. Diagnostics (Basel) 15: 38, Dec 2024.

Yadav VK, Mohan S, Agarwal S, de Godoy LL, Rajan A, Nasrallah MP, Bagley SJ, Brem S, Loevner LA, Poptani H, Singh A, Chawla S.: Distinction of pseudoprogression from true progression in glioblastomas using machine learning based on multiparametric magnetic resonance imaging and O(6)-methylguanine-methyltransferase promoter methylation status. Neurooncol Adv 6: vdae159, Oct 2024.

Tapescu I, Madsen PJ, Lowenstein PR, Castro MG, Bagley SJ, Fan Y, Brem S.: The transformative potential of mRNA vaccines for glioblastoma and human cancer: technological advances and translation to clinical trials. Front Oncol 14: 1454370, Sep 2024.

Gongala S, Garcia JA, Korakavi N, Patil N, Akbari H, Sloan A, Barnholtz-Sloan JS, Sun J, Griffith B, Poisson LM, Booth TC, Jain R, Mohan S, Nasralla MP, Bakas S, Tippareddy C, Puig J, Palmer JD, Shi W, Colen RR, Sotiras A, Ahn SS, Park YW, Davatzikos C, Badve C; ReSPOND Consortium.: Sex-Specific Differences in Patients with IDH1-Wild-Type Grade 4 Glioma in the ReSPOND Consortium. AJNR Am J Neuroradiol 45: 1299-1307, Sep 2024.

Brem S.: Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity. Brain Behav Immun Health 42: 100859, Sep 2024.

Richardson TE, Walker JM, Hambardzumyan D, Brem S, Hatanpaa KJ, Viapiano MS, Pai B, Umphlett M, Becher OJ, Snuderl M, McBrayer SK, Abdullah KG, Tsankova NM.: Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma. Acta Neuropathol 148: 5, Jul 2024.

Liu J, Cao S, Imbach KJ, Gritsenko MA, Lih TM, Kyle JE, Yaron-Barir TM, Binder ZA, Li Y, Strunilin I, Wang YT, Tsai CF, Ma W, Chen L, Clark NM, Shinkle A, Naser Al Deen N, Caravan W, Houston A, Simin FA, Wyczalkowski MA, Wang LB, Storrs E, Chen S, Illindala R, Li YD, Jayasinghe RG, Rykunov D, Cottingham SL, Chu RK, Weitz KK, Moore RJ, Sagendorf T, Petyuk VA, Nestor M, Bramer LM, Stratton KG, Schepmoes AA, Couvillion SP, Eder J, Kim YM, Gao Y, Fillmore TL, Zhao R, Monroe ME, Southard-Smith AN, Li YE, Jui-Hsien Lu R, Johnson JL, Wiznerowicz M, Hostetter G, Newton CJ, Ketchum KA, Thangudu RR, Barnholtz-Sloan JS, Wang P, Fenyƶ D, An E, Thiagarajan M, Robles AI, Mani DR, Smith RD, Porta-Pardo E, Cantley LC, Iavarone A, Chen F, Mesri M, Nasrallah MP, Zhang H, Resnick AC, Chheda MG, Rodland KD, Liu T, Ding L; Philadelphia Coalition for a Cure; Clinical Proteomic Tumor Analysis Consortium.: Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell 42: 1217-1238, Jul 2024.

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Last updated: 07/20/2025
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