Steven Brem, M.D.

faculty photo
Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery
Philadelphia, PA 19104
Office: (215) 662-3487
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications

Liu Tianrun, Ma Wenjuan, Xu Haineng, Huang Menggui, Zhang Duo, He Zhenqiang, Zhang Lin, Brem Steven, O'Rourke Donald M, Gong Yanqing, Mou Yonggao, Zhang Zhenfeng, Fan Yi: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nature communications 9(1): 3439, Aug 2018.

Liau Linda M, Ashkan Keyoumars, Tran David D, Campian Jian L, Trusheim John E, Cobbs Charles S, Heth Jason A, Salacz Michael, Taylor Sarah, D'Andre Stacy D, Iwamoto Fabio M, Dropcho Edward J, Moshel Yaron A, Walter Kevin A, Pillainayagam Clement P, Aiken Robert, Chaudhary Rekha, Goldlust Samuel A, Bota Daniela A, Duic Paul, Grewal Jai, Elinzano Heinrich, Toms Steven A, Lillehei Kevin O, Mikkelsen Tom, Walbert Tobias, Abram Steven R, Brenner Andrew J, Brem Steven, Ewend Matthew G, Khagi Simon, Portnow Jana, Kim Lyndon J, Loudon William G, Thompson Reid C, Avigan David E, Fink Karen L, Geoffroy Francois J, Lindhorst Scott, Lutzky Jose, Sloan Andrew E, Schackert Gabriele, Krex Dietmar, Meisel Hans-Jorg, Wu Julian, Davis Raphael P, Duma Christopher, Etame Arnold B, Mathieu David, Kesari Santosh, Piccioni David, Westphal Manfred, Baskin David S, New Pamela Z, Lacroix Michel, May Sven-Axel, Pluard Timothy J, Tse Victor, Green Richard M, Villano John L, Pearlman Michael, Petrecca Kevin, Schulder Michael, Taylor Lynne P, Maida Anthony E, Prins Robert M, Cloughesy Timothy F, Mulholland Paul, Bosch Marnix L: Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma. Journal of translational medicine 16(1): 179, Jun 2018.

Liau Linda M, Ashkan Keyoumars, Tran David D, Campian Jian L, Trusheim John E, Cobbs Charles S, Heth Jason A, Salacz Michael, Taylor Sarah, D'Andre Stacy D, Iwamoto Fabio M, Dropcho Edward J, Moshel Yaron A, Walter Kevin A, Pillainayagam Clement P, Aiken Robert, Chaudhary Rekha, Goldlust Samuel A, Bota Daniela A, Duic Paul, Grewal Jai, Elinzano Heinrich, Toms Steven A, Lillehei Kevin O, Mikkelsen Tom, Walbert Tobias, Abram Steven R, Brenner Andrew J, Brem Steven, Ewend Matthew G, Khagi Simon, Portnow Jana, Kim Lyndon J, Loudon William G, Thompson Reid C, Avigan David E, Fink Karen L, Geoffroy Francois J, Lindhorst Scott, Lutzky Jose, Sloan Andrew E, Schackert Gabriele, Krex Dietmar, Meisel Hans-Jorg, Wu Julian, Davis Raphael P, Duma Christopher, Etame Arnold B, Mathieu David, Kesari Santosh, Piccioni David, Westphal Manfred, Baskin David S, New Pamela Z, Lacroix Michel, May Sven-Axel, Pluard Timothy J, Tse Victor, Green Richard M, Villano John L, Pearlman Michael, Petrecca Kevin, Schulder Michael, Taylor Lynne P, Maida Anthony E, Prins Robert M, Cloughesy Timothy F, Mulholland Paul, Bosch Marnix L: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma. Journal of translational medicine 16(1): 142, May 2018.

Chawla Sanjeev, Wang Sumei, Mohan Suyash, Nasrallah MacLean, Verma Gaurav, Brem Steven, O'Rourke Donald M, Wolf Ronald L, Poptani Harish, Nabavizadeh S Ali: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. Journal of magnetic resonance imaging : JMRI Apr 2018.

Wang Qirui, He Zhenqiang, Huang Menggui, Liu Tianrun, Wang Yanling, Xu Haineng, Duan Hao, Ma Peihong, Zhang Lin, Zamvil Scott S, Hidalgo Juan, Zhang Zhenfeng, O'Rourke Donald M, Dahmane Nadia, Brem Steven, Mou Yonggao, Gong Yanqing, Fan Yi: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nature communications 9(1): 559, Feb 2018.

Prateek Agarwal, Arka N. Mallela, Nicholas Goel, Joseph Durgin, Donald M. O’Rourke, Kalil G. Abdullah, Steven Brem: Factors Associated with Ventriculoperitoneal Shunt Dependency Following Glioblastoma Resection. Proceedings of AANS 2018.

Snyder KJG, Ahmed FI, Brem S, Abdullah KG: Use of decision analytics modeling to assist in neurosurgical decision making: a feasibility study in elderly patients undergoing glioblastoma resection versus biopsy. Proceedings of AANS 2018.

Kalil G. Abdullah1, Nicholas J. Goel1, Prateek Agarwal1, Arka N. Mallela, Eileen Maloney Wilensky, Donald M. O’Rourke, Steven Brem: Factors associated with increased survival in patients undergoing 3 or more resections of recurrent glioblastoma. Proceedings of AANS 2018.

Kalil G. Abdullah, Nicholas J. Goel, Prateek Agarwal, Arka N. Mallela, Eileen Maloney Wilensky, Donald M. O’Rourke, Steven Brem: Factors associated with increased survival in patients undergoing 3 or more resections of recurrent glioblastoma. Proceedings of AANS 2018.

Ahmed FI, Durgin J, Agarwal P, MacFawn, O, Barrow M, O’Rourke DM, Abdullah KG , Brem S: Quantifying Extent of Resection Thresholds for Increased Survival in Elderly Patients with Glioblastoma. Proceedings of AANS 2018.

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Last updated: 09/27/2018
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