Faculty

Edward B Lee, MD, PhD

Associate Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

613A Stellar Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104

Office: 215-898-0908
Lab: 215-662-6696

Email:
edward.lee@pennmedicine.upenn.edu

Education:
BS (Biological Sciences)
Stanford University, 1997.
PhD (Neuroscience)
University of Pennsylvania School of Medicine, 2004.
MD
University of Pennsylvania School of Medicine, 2005.

Links
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Neuropathology

Description of Research Expertise

Alzheimer's disease
Frontotemporal lobar degeneration
Amyotrophic lateral sclerosis

Selected Publications

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q: Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews. Neuroscience 13(1): 38-50, Nov 2011.

Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011 Notes: *Lionel M Igaz, Linda K Kwong and Edward B Lee are co-lead authors.

Liu Elaine Y, Russ Jenny, Wu Kathryn, Neal Donald, Suh Eunran, McNally Anna G, Irwin David J, Van Deerlin Vivianna M, Lee Edward B: C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta neuropathologica 128(4): 525-41, Oct 2014.

Russ Jenny, Liu Elaine Y, Wu Kathryn, Neal Donald, Suh EunRan, Irwin David J, McMillan Corey T, Harms Matthew B, Cairns Nigel J, Wood Elisabeth M, Xie Sharon X, Elman Lauren, McCluskey Leo, Grossman Murray, Van Deerlin Vivianna M, Lee Edward B: Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta neuropathologica 129(1): 39-52, Jan 2015.

McMillan Corey T, Russ Jenny, Wood Elisabeth M, Irwin David J, Grossman Murray, McCluskey Leo, Elman Lauren, Van Deerlin Vivanna, Lee Edward B: C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology 84(16): 1622-30, Apr 2015.