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Description of Research Expertise

CAR-T cell metabolism; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Post-transcriptional gene suppression by shRNA and microRNA's; Bio-engineered cell culture platforms; Tissue stem cell differentiation;

Description of Clinical Expertise

Clinical Research Coordinator

Description of Other Expertise

Biomedical Expert (Local News Affiliate)

Selected Publications

Akbari B, Hosseini Z, Shahabinejad P, Ghassemi S, Mirzaei HR, O'Connor RS.: Metabolic and epigenetic orchestration of (CAR) T cell fate and function. Cancer Lett 550: 215948, Dec 2022 Notes: No issue.

Zhang H, Yu P, Tomar VS, Chen X, Atherton MJ, Lu Z, Zhang HG, Li S, Ortiz A, Gui J, Leu NA, Yan F, Blanco A, Meyer-Ficca ML, Meyer RG, Beiting DP, Li J, Nunez-Cruz S, O'Connor RS, Johnson LR, Minn AJ, George SS, Koumenis C, Diehl JA, Milone MC, Zheng H, Fuchs SY.: Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. Nat Cancer 3(7): 808-820, Jul 2022.

Ghassemi S, Durgin JS, Nunez-Cruz S, Patel J, Leferovich J, Pinzone M, Shen F, Cummins KD, Plesa G, Cantu VA, Reddy S, Bushman FD, Gill SI, O'Doherty U, O'Connor RS, Milone MC.: Rapid manufacturing of non-activated potent CAR T cells. Nat Biomed Eng 6(2): 118-128, Feb 2022.

Durgin JS, Thokala R, Johnson L, Song E, Leferovich J, Bhoj V, Ghassemi S, Milone M, Binder Z, O'Rourke DM, O'Connor RS.: Enhancing CAR T Function with the Engineered Secretion of C. Perfringens Neuraminidase. Mol Ther 30: 1201-1214, Nov 2021.

Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR.: Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Front Immunol 12: 757836, Oct 2021 Notes: No issue.

Garcia-Canaveras JC, Heo D, Trefely S, Leferovich J, Xu C, Philipson BI, Ghassemi S, Milone MC, Moon EK, Snyder NW, June CH, Rabinowitz JD, O'Connor RS.: CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells 10(9): 2334, Sep 2021.

Safarzadeh Kozani P, Safarzadeh Kozani P, O'Connor RS.: In Like a Lamb; Out Like a Lion: Marching CAR T Cells Toward Enhanced Efficacy in B-ALL. Mol Cancer Ther 20(7): 1223-1233, Jul 2021.

Tu VY, Ayari A, O'Connor RS.: Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer. Antibodies (Basel) 10(3): 25, Jun 2021.

Durgin JS, Henderson F Jr, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM.: Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Front Oncol 11: 669071, May 2021 Notes: No issue.

Kozani PS, Kozani PS, O'Connor RS.: Humanized Chimeric Antigen Receptor (CAR) T cells. J Cancer Immunol (Wilmington) 3(4): 182-187, Feb 2021.

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Last updated: 02/27/2023
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