Faculty

David B. Frank, MD, PhD

Assistant Professor of Pediatrics (Cardiology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3401 Civic Center Boulevard
8NW37, Division of Pediatric Cardiology
Philadelphia, PA 19104

Office: (267) 648-2626
Fax: 215-590-1340

Publications

Search PubMed for articles

Education:
B.S. (Biochemistry)
University of Nebraska-Lincoln, 1997.
Ph.D. (Cell and Developmental Biology and Philosophy)
Vanderbilt University School of Medicine, 2006.
M.D.
Vanderbilt University of School of Medicine, 2009.

Links
Search PubMed for articles
Penn CVI website
Lab website

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Niethamer TK, Planer JD, Morley MP, Babu A, Zhao G, Basil MC, Cantu E, Frank DB, Diamond JM, Nottingham AN, Li S, Sharma A, Hallquist H, Levin LI, Zhou S, Vaughan AE, Morrisey EE: Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states. Cell Stem Cell 32(2): 302-321, February 2025.

Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer 6(1): 102-122, January 2025.

Negretti NM, Son Y, Crooke P, Plosa EJ, Benjamin JT, Jetter CS, Bunn C, Mignemi N, Marini J, Hackett AN, Ransom M, Garg S, Nichols D, Guttentag SH, Pua HH, Blackwell TS, Zacharias W, Frank DB, Kozub JA, Mahadevan-Jansen A, Krystofiak E, Kropski JA, Wright CV, Millis B, Sucre JM: Epithelial outgrowth through mesenchymal rings drives alveologenesis. JCI Insight January 2025.

Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki SN, Gentile ME, Singh M, Kass-Gergi S, Mendoza M, Holcomb NP, Li X, Tang AT, Negretti NM, Sucre JMS, Frank DB*, Vaughan AE*, * co-corresponding authors: Dynamic behavior and lineage plasticity of the pulmonary venous endothelium. Nat Cardiovasc Res 3(12): 1584-1600, December 2024.

Wang JY, Michki SN, Sitaraman S, Banaschewski BJ, Jamal R, Gokey JJ, Lin SM, Katzen JB, Basil MC, Cantu E, Kropski JA, Zepp JA, Frank DB, Young LR. Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome.: Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight December 2024.

Prashant Chandrasekaran, Abdulaziz Alanazi , Bryan Kwok , Qing Li, Girish Viraraghavan, Sriram Balasubramanian, David B Frank , X Lucas Lu, David E Birk, Robert L Mauck, Nathaniel A Dyment , Eiki Koyama , Lin Han: Type V collagen exhibits distinct regulatory activities in TMJ articular disc versus condylar cartilage during postnatal growth and remodeling. Acta Biomater October 2024.

Maureen Peers de Nieuwburgh, Mallory Hunt, Prashant Chandrasekaran, Tiffaney L Vincent, Kevin B Hayes, Isabel R Randazz, Meredith Gunder , Felix R De Bie, Arthur Colson, Minqi Lu, Hongbo Wen, Sylvia N Michki, Jack Rychik , Fréderic Debiève, Jeremy Katzen, Lisa R Young, Marcus G Davey, Alan W Flake, J William Gaynor, David B Frank: Chronic Hypoxia in an EXTrauterine Environment for Neonatal Development Impairs Lung Development. Am J Respir Cell Mol Biol October 2024.

Avitabile CM, Zhang X, Ampah S, Wang Y, Ash D, Nilan K, Tingo JE, Frank DB, Jensen EA, Lingappan K, Gibbs KA: Elevated pulmonary capillary wedge pressure, higher blood pressure, and lower cardiac index in infants with bronchopulmonary dysplasia. Int J Cardiol September 2024.

Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT: The genomic basis of childhood T-lineage acute lymphoblastic leukaemia. Nature 632(8027): 1082-1091, August 2024.

Chaudhry FN, Michki NS, Shirmer DL, McGrath-Morrow S, Young LR, Frank DB, Zepp JA: Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis. Development 151(8), April 2024.