Faculty

Benjamin L. Prosser, Ph.D

Associate Professor of Physiology

Department: Physiology

Graduate Group Affiliations

Contact information

Clinical Research Building Rm 779
415 Curie Blvd.
Philadelphia, PA 19104

Office: 215-746-1488

Email:
bpros@mail.med.upenn.edu

Publications

Search PubMed for articles

Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.

Links
Search PubMed for articles
Prosser lab website
Center for Epilepsy and NeuroDevelopmental Disorders

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

myocyte biology
mechanobiology
heart failure
cytoskeleton
microtubules
excitation-contraction coupling

Selected Publications

Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL, Margulies KB.: Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Sci Transl Med. 16, July 2024.

Goss JR, Prosser BL, Helbig I, Son Rigby C.: STXBP1: fast-forward to a brighter future – a patient organization perspective. Ther Adv Rare Dis. 18(5), June 2024.

Aiste Liutkute, Benjamin L Prosser, Niels Voigt.: Microtubules: highway to … arrhythmia? Cardiovascular Research 120(7): 671-672, May 2024.

Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG.: Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity. Circ Res. 134(5): 482-501, Mar 2024.

Marotta N, Boland MJ, Prosser BL.: Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders. Probl Pediatr Adolesc Health Care. Mar 2024.

Thalwitzer KM, Xian J, deCampo D, Parthasarathy S, Magielski J, Sullivan KR, Goss J, Rigby CS, Boland M, Prosser B, Ruggiero SM, Syrbe S, Helbig I.: Early life seizures and epileptic spasms in STXBP1 -related disorders. Epilepsia 65(3), Mar 2024.

Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L.: Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function. bioRxiv Feb 2024.

McAfee Q, Caporizzo MA, Uchida K, Bedi KC, Margulies KB, Arany Z, Prosser BL. : Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. J Clin Invest. 134(2): e170196, Jan 2024.

Xian J, Thalwitzer KM, McKee J, Sullivan KR, Brimble E, Fitch E, Toib J, Kaufman MC, deCampo D, Cunningham K, Pierce SR, Goss J, Son Rigby C, Syrbe S, Boland M, Prosser B, Fitter N, Ruggiero SM, Helbig I.: Delineating clinical and developmental outcomes in STXBP1-related disorders. Brain 146(12): 5182-5197, Dec 2023.

BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A.: Adult human cardiomyocyte mechanics in osteogenesis imperfecta. Am J Physiol Heart Circ Physiol. 325(4): H814-H821, Oct 2023.