Benjamin L. Prosser, Ph.D

faculty photo
Associate Professor of Physiology
Department: Physiology

Contact information
Clinical Research Building Rm 779
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
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Description of Research Expertise

myocyte biology
heart failure
excitation-contraction coupling

Selected Publications

Marotta N, Boland MJ, Prosser BL.: Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders. Probl Pediatr Adolesc Health Care. Mar 2024.

Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG.: Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity. Circ Res. 134(5): 482-501, Mar 2024.

Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L.: Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function. bioRxiv Feb 2024.

McAfee Q, Caporizzo MA, Uchida K, Bedi KC, Margulies KB, Arany Z, Prosser BL. : Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. J Clin Invest. 134(2): e170196, Jan 2024.

Benjamin L. Prosser.: Pinpointing the contributors to myocardial passive stiffness. Nat. Cardiovas. Res. 2: 962–963, Oct 2023.

BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A.: Adult human cardiomyocyte mechanics in osteogenesis imperfecta. Am J Physiol Heart Circ Physiol. 325(4): H814-H821, Oct 2023.

Andrea D. Thompson, Marcus J. Wagner, Juliani Rodriguez, Alok Malhotra, Steve Vander Roest, Ulla Lilienthal, Hao Shao, Mathav Vignesh, Keely Weber, Jaime M. Yob, Benjamin L. Prosser, Adam S. Helms, Jason E. Gestwicki, David Ginsburg, Sharlene M. Day.: An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3. J Am Coll Cardiol Basic Trans Science 8(9): 1198–1211, Sep 2023.

Thalwitzer KM, Xian J, deCampo D, Parthasarathy S, Magielski J, Sullivan KR, Goss J, Rigby CS, Boland M, Prosser B, Ruggiero SM, Syrbe S, Helbig I.: Early life seizures and epileptic spasms in STXBP1 -related disorders. medRxiv Jun 2023.

Luciani M, Montalbano M, Troncone L, Bacchin C, Uchida K, Daniele G, Jacobs Wolf B, Butler HM, Kiel J, Berto S, Gensemer C, Moore K, Morningstar J, Diteepeng T, Albayram O, Abisambra JF, Norris RA, Di Salvo TG, Prosser B, Kayed R, Del Monte F.: Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy. Eur Heart J 44: 1560-1570, May 2023.

Xian J, Thalwitzer KM, McKee J, Sullivan KR, Brimble E, Fitch E, Toib J, Kaufman MC, deCampo D, Cunningham K, Pierce SR, Goss J, Son Rigby C, Syrbe S, Boland M, Prosser B, Fitter N, Ruggiero SM, Helbig I.: Delineating clinical and developmental outcomes in STXBP1-related disorders. medRxiv May 2023.

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Last updated: 04/12/2024
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