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Faculty

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Klaus Hopster, DVM, PhD

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1f Graduate Group Affiliations 8 a
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University of Pennsylvania
25 School of Veterinary Medicine
2a Department of Clinical Studies-NBC
39 382 West Street Road
Kennett Square, PA 19348
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2c Office: 6109256601
30 Fax: 6109256820
30 Lab: 6109256125
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18 Publications
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13 Education:
21 8 DMV 20 (Veterinary Medicine) c
43 University of Veterinary Medicine Hannover, 2006.
21 d DrMedVet 20 (Veterinary Medicine) c
3f School of Veterinary Medicine Hannover, 2007.
21 8 PhD 62 (Microperfusion and oxygenation of the gastrointestinal tract in anesthetitized horses) c
50 The University of Veterinary Medicine Hannover, Germany, 2019.
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b6 > Perelman School of Medicine   > Faculty   > Details a
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Description of Research Expertise

eb Peripheral tissue oxygenation during anesthesia in horses, focusing on establishment of new ventilation modes to improve the oxygen uptake during anesthesia with no to minimal interaction with the cardiovascular system
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30 Pain assessment and management in horses
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3e New modalities of locoregional anesthesia and analgesia
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Selected Publications

141 Adler, D. M. T., Hopster, K., Hopster-Iversen, C., Fenner, M., Buhl, R., Jacobsen, S.: Thoracotomy and Pericardiotomy for Access to the Heart in Horses: Surgical Procedure and Effects on Anesthetic Variables. J Equine Vet Sci 96: 103315, 2021.

12e VanderBroek, A. R., Engiles, J. B., Kästner, S. B. R., Kopp, V., Verhaar, N., Hopster, K.: Protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in horses. Equine Vet J 53(3): 569-578, 2021.

117 Hurcombe, S. D., Klein, C. E., Roessner, H. A., Engiles, J. B., Hopster, K.: Use of polyamide cable ties during experimental omentectomy in adult horses with histopathological assessment. Vet Surg 2021.

de Floriano, D. A., Hopster, K., Broek, A. R. V., Reef, V. B., Slack, J.: Anesthesia Case of the Month. J Am Vet Med Assoc 258(12): 1341-1344, 2021.

138 Arndt, S., Hopster, K., Sill, V., Rohn, K., Kästner, S. B. R.: Comparison between head-tail-rope assisted and unassisted recoveries in healthy horses undergoing general anesthesia for elective surgeries. Vet Surg 49(2): 329-338, 2020.

13e Luethy, D., Hopster, K.: Electrolyte measurement in goats: Comparison of 2 blood gas analyzers and evaluation of the preanalytical blood sample preparation on measurement results. Tierarztl Prax Ausg G Grosstiere Nutztiere 48(3): 148-155, 2020.

160 König, K. S., Verhaar, N., Hopster, K., Pfarrer, C., Neudeck, S., Rohn, K., Kästner, S. B. R.: Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion. PLoS ONE 15(4): e0224720, 2020.

115 Hurcombe, S. D., Morris, T. B., VanderBroek, A. R., Habecker, P., Wulster, K., Hopster, K.: Cervical Epidural and Subarachnoid Catheter Placement in Standing Adult Horses. Front Vet Sci 7: 232, 2020.

132 Hopster, K., Soma, L. R., Li, X., Hopster-Iversen, C., Boston, R. C., Driessen, B.: Pharmacokinetics of xylazine after 2-, 4-, and 6-hr durations of continuous rate infusions in horses. J Vet Pharmacol Ther 43(6): 557-564, 2020.

15c Gaesser, A. M., Varner, K. M., Douglas, H. F., Barr, C. A., Hopster, K., Levine, D. G.: The effect of intra-articular mepivacaine administration prior to carpal arthroscopy on anesthesia management and recovery characteristics in horses. Vet Surg 49(7): 1343-1349, 2020.

ef Floriano, D., Hopster, K., Driessen, B.: Accuracy of tidal volume delivery by five different models of large-animal ventilators. Am J Vet Res 81(11): 857-864, 2020.

14e Douglas, H., Hopster, K., Cerullo, M., Hopster-Iversen, C., Stefanovski, D., Driessen, B.: The effects of flumazenil on ventilatory and recovery characteristics in horses following midazolam-ketamine induction and isoflurane anaesthesia. Equine Vet J 2020.

106 Crandall, A., Hopster, K., Grove, A., Levine, D.: Intratesticular mepivacaine versus lidocaine in anaesthetised horses undergoing Henderson castration. Equine Vet J 52(6): 805-810, 2020.

11e Cerullo, M., Driessen, B., Douglas, H., Hopster, K.: Changes in Arterial Blood Pressure and Oxygen Tension as a Result of Hoisting in Isoflurane Anesthetized Healthy Adult Horses. Front Vet Sci 7: 601326, 2020.

146 Echelmeyer, J., Taylor, P. M., Hopster, K., Rohn, K., Delarocque, J., Kästner, S. B. R.: Effect of fentanyl on thermal and mechanical nociceptive thresholds in horses and estimation of anti-nociceptive plasma concentration. Vet J 249: 82-88, 2019.

126 Varner, K. M., Hopster, K., Driessen, B.: Comparison of various types of inert gas components on efficacy of an alveolar recruitment maneuver in dorsally recumbent anesthetized horses. Am J Vet Res 80(7): 631-636, 2019.

13c Hopster, K., Bertone, C., Driessen, B.: Evaluation of the effects of gas volume and composition on accuracy of volume measurement by two flow sensors and delivery by a piston-driven large-animal ventilator. Am J Vet Res 80(2): 135-143, 2019.

13b Dancker, C., Hopster, K., Rohn, K., Kästner, S. B.: Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses. Equine Vet J 50(1): 104-110, 2018.

147 Wittenberg-Voges, L., Kästner, S. B., Raekallio, M., Vainio, O. M., Rohn, K., Hopster, K.: Effect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses. Vet Anaesth Analg 45(2): 165-174, 2018.

112 Reiners, J. K., Rossdeutscher, W., Hopster, K., Kästner, S. B. R.: Development and clinical evaluation of a new sensor design for buccal pulse oximetry in horses. Equine Vet J 50(2): 228-234, 2018.

175 Neudeck, S., Kästner, S. B. R., Wittenberg-Voges, L., Rohn, K., Hopster, K.: Comparison of desflurane and propofol at equipotent doses in combination with a constant rate infusion of dexmedetomidine on global and peripheral perfusion and oxygenation in horses. Am J Vet Res 79(5): 487-495, 2018.

110 Hopster, K., Neudeck, S., Wittenberg-Voges, L., Kästner, S. B.: The relationship between intestinal and oral mucosa microcirculation in anaesthetized horses. Vet Anaesth Analg 45(1): 78-81, 2018.

160 Hopster, K., Duffee, L. R., Hopster-Iversen, C. C. S., Driessen, B.: Efficacy of an alveolar recruitment maneuver for improving gas exchange and pulmonary mechanics in anesthetized horses ventilated with oxygen or a helium-oxygen mixture. Am J Vet Res 79(10): 1021-1027, 2018.

15f Hopster K, Wittenberg-Voges L, Geburek F, Hopster-Iversen C, Kästner SBR : Effects of controlled hypoxemia or hypovolemia on global and intestinal oxygenation and perfusion in anesthetized horses. BMC Vet Res 28;13(1): 361, November 2017 Notes: doi: 10.1186/s12917-017-1265-3.

18b Yavari, S., Khraim, N., Szura, G., Starke, A., Engelke, E., Pfarrer, C., Hopster, K., Schmicke, M., Kehler, W., Heppelmann, M., Kästner, S. B. R., Rehage, J.: Evaluation of intravenous regional anaesthesia and four-point nerve block efficacy in the distal hind limb of dairy cows. BMC Vet Res 13(1): 320, 2017.

130 Müller, T. M., Hopster, K., Bienert-Zeit, A., Rohn, K., Kästner, S. B. R.: Effect of butorphanol, midazolam or ketamine on romifidine based sedation in horses during standing cheek tooth removal. BMC Vet Res 13(1): 381, 2017.

130 Hopster, K., Wittenberg-Voges, L., Kästner, S. B. R.: Xylazine infusion in isoflurane-anesthetized and ventilated healthy horses: Effects on cardiovascular parameters and intestinal perfusion. Can J Vet Res 81(4): 249-254, 2017.

12e Hopster, K., Ambrisko, T. D., Kästner, S. B. R.: Influence of catecholamines at different dosages on the function of the LiDCO sensor in isoflurane anesthetized horses. J Vet Emerg Crit Care (San Antonio) 27(6): 651-657, 2017.

133 Dönselmann Im Sande, P., Hopster, K., Kästner, S.: [Effects of morphine, butorphanol and levomethadone in different doses on thermal nociceptive thresholds in horses] Tierarztl Prax Ausg G Grosstiere Nutztiere 45(2): 98-106, 2017.

167 Ambrisko, T. D., Schramel, J., Hopster, K., Kästner, S., Moens, Y.: Assessment of distribution of ventilation and regional lung compliance by electrical impedance tomography in anaesthetized horses undergoing alveolar recruitment manoeuvres. Vet Anaesth Analg 44(2): 264-272, 2017.

141 Hopster K, Ambrisko TD, Kästner SBR : Influence of catecholamines at different dosages on the function of the LiDCO sensor in isoflurane anesthetized horses. J Vet Emerg Crit Care (San Antonio) Page: 24, October 2017 Notes: doi: 10.1111/vec.12672.

139 Hopster, K., Jacobson, B., Hopster-Iversen, C., Rohn, K., Kästner, S. B.: Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies. Res Vet Sci 107: 8-15, 2016.

128 Tünsmeyer, J., Hopster, K., Kästner, S. B.: Clinical Use of a Multivariate Electroencephalogram (Narcotrend) for Assessment of Anesthetic Depth in Horses during Isoflurane-Xylazine Anesthesia. Front Vet Sci 3: 25, 2016.

13a Rieder, C. M., Staszyk, C., Hopster, K., Feige, K., Bienert-Zeit, A.: Maxillary nerve block within the equine pterygopalatine fossa with different volumes: practicability, efficacy and side-effects. Pferdeheilkunde 32(2): 132-140, 2016.

117 Hopster, K., Wogatzki, A., Conze, P., Kästner, S. B.: Effects of positive end-expiratory pressure titration on intestinal oxygenation and perfusion in isoflurane anaesthetised horses. Equine Vet J 2016.

14d Hopster, K., Rohn, K., Ohnesorge, B., Kästner, S. B.: Controlled mechanical ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvres during anaesthesia in laterally or dorsally recumbent horses. Vet Anaesth Analg 2016.

11d Hopster, K., Ambrisko, T. D., Stahl, J., Schramel, J. P., Kästner, S. B.: Influence of xylazine on the function of the LiDCO sensor in isoflurane anaesthetized horses. Vet Anaesth Analg 42(2): 142-149, 2015.

14e Tünsmeyer, J., Hopster, K., Feige, K., Kästner, S. B.: Agreement of high definition oscillometry with direct arterial blood pressure measurement at different blood pressure ranges in horses under general anaesthesia. Vet Anaesth Analg 42(3): 286-291, 2015.

119 Pöppel, N., Hopster, K., Geburek, F., Kästner, S.: Influence of ketamine or xylazine supplementation on isoflurane anaesthetized horses--a controlled clinical trial. Vet Anaesth Analg 42(1): 30-38, 2015.

128 Hopster, K., Hopster-Iversen, C., Geburek, F., Rohn, K., Kästner, S. B.: Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses. Vet J 205(1): 62-68, 2015.

173 Conze, P., van Schie, H. T., van Weeren, R., Staszyk, C., Conrad, S., Skutella, T., Hopster, K., Rohn, K., Stadler, P., Geburek, F.: Effect of autologous adipose tissue-derived mesenchymal stem cells on neovascularization of artificial equine tendon lesions. Regen Med 9(6): 743-757, 2014.

152 Reichert, C., Kästner, S. B., Hopster, K., Rohn, K., Rötting, A. K.: Use of micro-lightguide spectrophotometry for evaluation of microcirculation in the small and large intestines of horses without gastrointestinal disease. Am J Vet Res 75(11): 990-996, 2014.

12e Hopster-Iversen, C. C., Hopster, K., Staszyk, C., Rohn, K., Freeman, D. E., Rötting, A. K.: Effects of experimental mechanical manipulations on local inflammation in the jejunum of horses. Am J Vet Res 75(4): 385-391, 2014.

176 Hopster, K., Müller, C., Hopster-Iversen, C., Stahl, J., Rohn, K., Kästner, S.: Effects of dexmedetomidine and xylazine on cardiovascular function during total intravenous anaesthesia with midazolam and ketamine and recovery quality and duration in horses. Vet Anaesth Analg 41(1): 25-35, 2014.

178 Gozalo-Marcilla, M., Hopster, K., Gasthuys, F., Krajewski, A. E., Schwarz, A., Schauvliege, S.: Minimum end-tidal sevoflurane concentration necessary to prevent movement during a constant rate infusion of morphine, or morphine plus dexmedetomidine in ponies. Vet Anaesth Analg 41(2): 212-219, 2014.

144 Gozalo-Marcilla, M., Hopster, K., Gasthuys, F., Hatz, L., Krajewski, A. E., Schauvliege, S.: Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies. Equine Vet J 45(2): 204-208, 2013.

15c Tappenbeck, K., Hoppe, S., Hopster, K., Kietzmann, M., Feige, K., Huber, K.: Lidocaine and structure-related mexiletine induce similar contractility-enhancing effects in ischaemia-reperfusion injured equine intestinal smooth muscle in vitro. Vet J 196(3): 461-466, 2013.

14d Poller, C., Hopster, K., Rohn, K., Kästner, S. B.: Evaluation of contact heat thermal threshold testing for standardized assessment of cutaneous nociception in horses - comparison of different locations and environmental conditions. BMC Vet Res 9: 4, 2013.

121 Poller, C., Hopster, K., Rohn, K., Kästner, S. B.: Nociceptive thermal threshold testing in horses - effect of neuroleptic sedation and neuroleptanalgesia at different stimulation sites. BMC Vet Res 9: 135, 2013.

161 Hopster, K., Bienert-Zeit, A., Hopster-Iversen, C., Kästner, S. B. R.: Influence of ketamine or midazolam in combination with a romifidine-butorphanol-constant rate infusion on sedation quality during tooth extraction in standing horses. Pferdeheilkunde 29(2): 220-227, 2013.

16a Hopster, K., Ohnesorge, B., von Borstel, M., Rohn, K., Kästner, S.: [Influence of atracurium on cardiovascular parameters in horses undergoing vitrectomy during general anaesthesia, and on recovery duration and quality] Tierarztl Prax Ausg G Grosstiere Nutztiere 41(6): 371-377, 2013.

135 Müller, C., Hopster, K., Hopster-lversen, C., Rohn, K., Kästner, S. B. R.: Elaboration of a xylazine and dexmedetomidine infusion regime which provides a constant level of sedation in horses. Pferdeheilkunde 28(6): 668-674, 2012.

15b Tappenbeck, K., Hoppe, S., Hopster, K., Kietzmann, M., Feige, K., Huber, K.: Influence of structural and lipophilic characteristics of lidocaine on its prokinetic effect in intestinal smooth muscle. Journal Of Veterinary Pharmacology And Therapeutics 35: 145-146, 2012.

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