Faculty

John T. Seykora, M.D., Ph.D

Professor of Dermatology

Department: Dermatology

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142

Office: 2158980170
Lab: 215 573 5063

Publications

Search PubMed for articles

Education:
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.

Links
Search PubMed for articles
Faculty web page

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections or the HoVert Technique
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Freeburg N F, Chafamo D, Gopikrishna GK, Murphy, RM, Peng, JJ, Parthasarathy, S, Dumont, D, Estrada, EE, Logun, MT, Sun Y, Wang X, Grover P, Rodriguez JL, Zhang DL, Park K, Fu Y, Hamouda NB, Hernandez-Verdi I, Lamrani L, Hicks KA, Cooper NA, Ekwebara C, Bawden EG, Waterfall JJ, Fuentealba J, Alcantra M, Seykora JT, Prouty SM, Barrett D, Banerjee E, Cox A, Assenmacher CA, Macia C, Yin M, Carpenter EL, Ming GL, Sautes-Fridman C, Fridman WH, Tartour E, Wherry EJ, Amigorena S, Fraietta JA, Nasrallah MP, Song H, Miller TE, Bagley SJ, O’Rourke DM, Binder ZA, Alanio C and Silverbush D: The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM. Cell June 2026.

Kuprasertkul N, Moore AF, D'souza CA, Chini J, Ko EK, Huang S, Zhang S, Anderson AS, Egolf S, Pinheiro LV, Jaccard A, Magahis CT, Bao L, Aubert Y, Olingou CR, Prouty SM, Brennan-Crispi D, Hill DA, Seykora JT, Wellen KE, Capell BC: Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression. J Clin Invest Mar 2026 Notes: epub ahead of print.

Natale CA, Mercado S, Zhuang R, Aguirre-Portolés C, Olayide I, Arnatt CK, Seykora JT, Garyantes TK, Luke W, Ridky TW. : An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development. Cancer Res Commun. Mar. 2025.

Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE.: Identification of Meibomian gland stem cell populations and mechanisms of aging. Nat Commun. Feb. 2025.

Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE.: Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. Cell Rep. Feb. 2025.

Hoffman CL, Bharathan NK, Shibata Y, Giang W, Gudjonsson JE, Seykora JT, Prouty SM, Stahley SN, Payne AS, Kowalczyk AP.: Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response. J Invest Dermatol. Feb. 2025.

Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci Dec. 2024.

Grice EA, Brennan-Crispi D, Rodriguez N, Margolis DJ, Seykora JT, Cotsarelis G, Taylor SC, Shuda J. : Penn Academy for Skin Health (PASH): An Experiential Pipeline Program in Skin Biology and Dermatology for High-School Students. J Invest Dermatol. Oct. 2024.

Abbott JJ, Jiang AJ, Godse R, Ahmed S, Senft SC, Wilson MA, Cohen JV, Mitchell TC, Ogunleye TA, Higgins HW 2nd, Shin TM, Miller CJ, Roth JJ, Priore SF, Castelo-Soccio L, Elenitsas R, Seykora JT, Nathanson KL, Chu EY: Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants. JAMA Dermatol. Sept. 2024.

Sati S, Huang J, Kersh AE, Jones P, Ahart O, Murphy C, Prouty SM, Hedberg ML, Jain V, Gregory SG, Leung DH, Seykora JT, Rosenbach M, Leung TH: Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases. J Clin Invest. Sept. 2024.