John T. Seykora, M.D., Ph.D

faculty photo
Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations

Contact information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

1. Alopecias-including analysis via horizontal sections or the HoVert Technique
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Maldonado López AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC.: Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Sci Adv. 2023 Sep;9(35), September 2023.

Jackson TK, Sow Y, Ayoade KO, Seykora JT, Taylor SC, Ogunleye T.: Central centrifugal cicatricial alopecia in males. J Am Acad Dermatol. 2023 24, July 2023.

Roche FC, Hedberg ML, Fischer AS, Ray A, Dentchev T, Rice X, Taylor SC, Seykora JT. : Activation of STAT3 in lymphocytes associated with central centrifugal cicatricial alopecia. J Am Acad Dermatol. 21:S0190-9622(23)00202-5., Feb 2023.

"Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH: Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome" J Clin Invest 133(1), January 2023 Notes: 2023 Jan 3;133(1):e162137. doi: 10.1172/JCI162137.

Zuraski CR, Wales C, Nguyen CV, Chan EF, Kovarik C, Seykora JT, Elenitsas R, Moshiri AS.: Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis. Am J Dermatopathol. 2022 Nov 1;44(11):812-816. doi: 10.1097/DAD.0000000000002249. Epub 2022 Jul 19. PMID: 35925148. Nov 1;44(11):812-816, Nov 2022.

Beer J, Bittar J, Hedberg ML, Seykora JT.: Violaceous truncal plaques consistent with amyloid light-chain amyloidosis. J Cutan Pathol. 49(10):889-892, Oct 2022.

Ko K, Merlet J, DerGarabedian B, Zhen H, Suzuki-Horiuchi Y, Hedberg M, Hu E, Nguyen A, Prouty S, Alawi F, Walsh M, Choi Y, Millar S, Cliff A, Romero J, Garvin M, Seykora J*, Jacobson D* and Graves D*-co Senior Authors.: “NF-kB Perturbation Reveals Unique Immunomodulatory Functions in Prx1+ Fibroblasts that Promote Atopic Dermatitis” . Sci Transl Med 14(630), February 2022 Notes: 2022 Feb 2;14(630):eabj0324. doi: 10.1126/scitranslmed.abj0324. Epub 2022 Feb 2.

Modi MB, Pei S, Hedberg ML, Fischer AS, Guerrero J, Carreon CK, Cooper K, Seykora JT: "Clinical, pathologic, and molecular analyses of superficial low-grade fibromyxoid sarcoma in two young patients: A rare and deceptive mimic of benignancy" J Cutan Pathol February 2022 Notes: 2022 Feb 22. doi: 10.1111/cup.14215. Epub ahead of print.

Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobsen EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T: “Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion” Science 30(373): 6554, July 2021 Jul 30;373(6554.

Aguirre-Portolés C., Payne R., Trautz A., Foskett J.K., Natale C.A., Seykora J.T., Ridky T.W.: ZIP9 is a Druggable Determinant of Sex Differences in Melanoma" Cancer Res 81(23): 5991-6003, December 2021 Notes: doi: 10.1158/0008-5472.CAN-21-0982. Epub 2021 Oct 27.

back to top
Last updated: 09/05/2023
The Trustees of the University of Pennsylvania