Faculty

John T. Seykora, M.D., Ph.D

Professor of Dermatology

Department: Dermatology

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142

Office: 2158980170
Fax: 2155732143
Lab: 215 573 5063

Publications

Search PubMed for articles

Education:
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.

Links
Search PubMed for articles
Faculty web page

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections or the HoVert Technique
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Maeno H, Suzuki-Horiuchi Y, Funakoshi A, Chumsakul O, Sato Y, Ishii T, Seykora JT: miR-4521-A novel biomarker for human lentigos. Exp Dermatol. 2024 33(6), June 2024.

Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol 144, May 2024.

Yang B, Alimperti S, Gonzalez MV, Dentchev T, Kim M, Suh J, Titchenell PM, Ko KI, Seykora J, Benakanakere M, Graves DT: Reepithelialization of Diabetic Skin and Mucosal Wounds Is Rescued by Treatment With Epigenetic Inhibitors. Diabetes. 73: 120-134, 2024.

Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC. : Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis. Dev Cell. 59(2), 2024.

Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ.: Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration. J Cell Biol. J Cell Biol. Nov 6;222(11), Nov 2023.

Maldonado López AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC.: Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue. Sci Adv. 2023 Sep;9(35), September 2023.

Jackson TK, Sow Y, Ayoade KO, Seykora JT, Taylor SC, Ogunleye T.: Central centrifugal cicatricial alopecia in males. J Am Acad Dermatol. 2023 24, July 2023.

Roche FC, Hedberg ML, Fischer AS, Ray A, Dentchev T, Rice X, Taylor SC, Seykora JT. : Activation of STAT3 in lymphocytes associated with central centrifugal cicatricial alopecia. J Am Acad Dermatol. 21:S0190-9622(23)00202-5., Feb 2023.

"Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh AE, Nelson CA, Bryer JS, Ashchyan HA, Steele K, Forrestel A, Seykora JT, Micheletti RG, James WD, Rosenbach M, Leung TH: Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome" J Clin Invest 133(1), January 2023 Notes: 2023 Jan 3;133(1):e162137. doi: 10.1172/JCI162137.

Zuraski CR, Wales C, Nguyen CV, Chan EF, Kovarik C, Seykora JT, Elenitsas R, Moshiri AS.: Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis. Am J Dermatopathol. 2022 Nov 1;44(11):812-816. doi: 10.1097/DAD.0000000000002249. Epub 2022 Jul 19. PMID: 35925148. Nov 1;44(11):812-816, Nov 2022.