Daniel P Kelly, MD

faculty photo
Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd.
Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-898-0768
Lab: 215-898-2374
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Franco A, Kelly DP, Hershberger RE, Marian AJ, Lewis RM, Song M, Dang X, Schmidt AD, Mathyer ME, de Guzman Strong C, Dorn II GW: A human mitofusin mutation pinpoints defective mitophagy as a cause of cardiomyopathy. eLife 12: e84235, Nov 2023.

Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoi DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP: RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. J Clin Invest 133(9): e162309, May 2023.

Hahn V, Petucci C, Kim MS, Bedi K, Wang H, Mishra S, Koleini N, Yoo E, Margulies K, Arany Z, Kelly DP, Kass D, and Sharma K: Myocardial Metabolomics of Human Heart Failure with Preserved Ejection Fraction. Circulation 147(15): 1147-1161, April 2023.

Cao Y, Zhang X, Akerberg B, Yuan H, Sakamoto T, Xiao F, VanDusen N, Zhou P, Sweat M, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu W: In vivo dissection of chamber selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity. Circulation 147(11): 881-896, March 2023.

Matsuura TR, Puchalska P, Crawford PA, Kelly DP: Ketones and the heart: Metabolic principles and therapeutic implications. Circ Res. 132(7): 882-898, March 2023.

Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Gunaje J, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM: MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states. bioRxiv March 2023.

Vite A, Matsuura TR, Bedi Jr KC, Flam EL, Kelly DP, Margulies KB: Functional impact of alternative metabolic substrates in human cardiomyocytes. JACC: BTS online ahead of print, 2023.

Vidula M, Kelly DP, Arany Z, Margulies KB, Shah SH, Cappola TP, Bavo PE, Selvaraj S: Metabolomic signatures of myocardial glucose uptake on FDG-PET. JACC BTS 7(12): 1264-1266, October 2022.

Sannigrahi MK, Rajagopalan P, Lai L, Liu X, Sahu V, Nakagawa H, Jalaly J, Brody R, Morgan IM, Windle BE, Wang X, Gimotty PA, Kelly DP, White EA, and Basu D: HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1a/ERRa axis. JCI Insight 7(18): e159600, Sep 2022.

Previs MJ, O’Leary TS, MP Morley, Palmer BM, LeWinter M, Yob JM, Pagani FD, Petucci C, Kim MS, Margulies KB, Arany Z, Kelly DP, Day SM: Defects in the proteome and metabolome in human hypertrophic cardiomyopathy. Circ Heart Failure 15(6): e009521, June 2022.

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Last updated: 11/29/2023
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