Faculty

Daniel P Kelly, MD

Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases

Department: Medicine

Graduate Group Affiliations

Contact information

3400 Civic Center Blvd.
Smilow Center for Translational Research
11-122
Philadelphia, PA 19104

Office: 215-898-0768
Lab: 215-898-2374

Email:
dankelly@pennmedicine.upenn.edu

Education:
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

166. Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, and Kelly DP: Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction. ESC Hear Failure August 2025.

Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH: Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial. JACC: BTS March 2025.

164. Selvaraj S, Karaj A, Chirinos J, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner S, Cohen J, Ischiropoulos H, Rickels M, Poole D, Church D, Wolfe R, Kelly DP, Putt M, Margulies K, Zamani P: Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail March 2025.

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific Reports 15(1), Jan 2025.

Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP: A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness. Submitted 2025.

Doan KV, Gaspar RB, Lee WD, Oschmann AM, Ts’olo TT, Frederick DW, Velِázquez Aponte RA, Adzika GK, McGaunn JP, Bye N, Mukherjee S, Davis JG, Holman CD, Chu Q, Garcia A, Ranamurthy R, Cheng L, Migaud ME, Rabinowitz JD, Kelly DP, Baur JA: Low cardiac NAD+ causes hypertrophy through a ketone-sensitive beta-adrenergic signaling pathway. Submitted 2025.

Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA: The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart. Submitted 2025.

Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA: Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res October 2024.

Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. CircRes August 2024.

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. bioRxiv June 2024.