Faculty

Daniel P Kelly, MD

Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases

Department: Medicine

Graduate Group Affiliations

Contact information

3400 Civic Center Blvd.
Smilow Center for Translational Research
11-122
Philadelphia, PA 19104

Office: 215-898-0768
Lab: 215-898-2374

Email:
dankelly@pennmedicine.upenn.edu

Education:
B.S. (Biology)
University of Illinois, 1978.
M.D. (Medicine )
University of Illinois College of Medicine, Chicago, Illinois, 1982.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. Scientific Reports 15(1), Jan 2025.

Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA: Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics. Nat Cardiovasc Res October 2024.

Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. CircRes August 2024.

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP: Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension. bioRxiv June 2024.

Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM: MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states. Circulation June 2024.

Williams AS, Crown SB, Lyons SP, Koves TR, Wilson RJ, Johnson JM, Slentz DH, Kelly DP, Grimsrud PA, Zhang GF, Muoio DM: Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding. Cell Metab February 2024.

Kelly DP: Replenishing the physician-scientist pipeline in the post-late bloomer era. J Clin Invest January 2024.

Vite A, Matsuura TR, Bedi Jr KC, Flam EL, Arany, Z, Kelly DP, Margulies KB: Functional impact of alternative metabolic substrates in failing human cardiomyocytes. JACC: BTS January 2024.

Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH: Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial. JACC: BTS In Press 2024.

Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP: Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for heart failure with reduced ejection fraction in mice. bioRxiv 2024.