Krithika Lingappan, MD MS PhD

faculty photo
Associate Professor of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Division of Neonatology
3401 Civic Center Boulevard
Philadelphia, PA 19014
MBBS (Medicine)
Kilpauk Medical College, TamilNadu Dr.MGR Medical University, India, 2002.
MS (Clinical Scientist Training Program)
Baylor College of Medicine, 2015.
PhD (Clinical Scientist Training Program)
Graduate School of Biomedical Sciences, Baylor College of Medicine, 2018.
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Description of Clinical Expertise

I take particular interest in evidence-based medicine (EBM) and have led several EBM initiatives. We are also interested in translational research projects related to long-term outcomes (pulmonary and cardiovascular) after preterm birth. I have leadership experience at national and regional organizations. As the leader of several national-level groups, I have created a unique niche for herself as a leader in the neonatology subspecialty with my involvement in the American Academy of Pediatrics (AAP), Section of neonatal-perinatal medicine (SONPM), NIH-funded lung basic-science research, evidence-based clinical neonatology practice, and trainee engagement and education.

Description of Research Expertise

My research focuses on reducing long-term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focuses on elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.

Selected Publications

Albertina Lee, Jonathan Edwards, Abiud Cantu, Krithika Lingappan: Neonatal Hyperoxia Exposure Impacts the Atria More Than Ventricles: Implications for Prematurity Related Cardiac Disease Poster Number 174. Pediatric Academic Societies Meeting Toronto, Canada 2024.

Eric Horowitz, Clyde Wright, Misty Good, Kerri Machut, Kaashif Ahmed, Krithika Lingappan: A Study of NIH-Funded Physician-Scientists in Neonatal-Perinatal Medicine: an exploration of gender differences across career stages Oral presentation. Session: Neonatal General 4: The Bigger Picture Pediatric Academic Societies Meeting Toronto, Canada 2024.

Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli X, Lingappan K, Moorthy B.: Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211: 35-46, Dec 2023.

Cantu A, Gutierrez MC, Dong X, Leek C, Anguera M, Lingappan K.: Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable. Redox Biology 68(102933), December 2023.

Albert R, Lee A, Lingappan K.: Response to Therapeutic Interventions in the NICU: Role of Sex as a Biological Variable. Neoreviews 24: e797-e805, Dec 2023.

Hammond JD 2nd, Kielt MJ, Conroy S, Lingappan K, Austin ED, Eldredge LC, Truog WE, Abman SH, Nelin LD, Guaman MC.: Exploring the Association of Male Sex With Adverse Outcomes in Severe Bronchopulmonary Dysplasia: A Retrospective, Multicenter Cohort Study. Chest Oct 2023.

Machut KZ, Lingappan K, Savich R, Dammann CEL.: Toolkit for gender equity in pediatrics. Pediatr Res Oct 2023.

Ryan RM, Mukherjee D, Ford S, Lingappan K.: Pharmacotherapy of BPD: Current status & future perspectives. Semin Perinatol Sep 2023.

Al-Mudares F, Cantu Gutierrez M, Cantu A, Jiang W, Wang L, Dong X, Moorthy B, Sajti E, Lingappan K.: Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice. Am J Physiol Lung Cell Mol Physiol 325: L314-L326, Sep 2023.

Lingappan K, Olutoye OO 2nd, Cantu A, Cantu Gutierrez ME, Cortes-Santiago N, Hammond JD, Gilley J, Quintero JR, Li H, Polverino F, Gleghorn JP, Keswani SG.: Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia. Am J Physiol Lung Cell Mol Physiol 325: L477-L486, Aug 2023.

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Last updated: 05/11/2024
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