c
2
12
18
28
12
12
1a
14
e
12
16
a
a
2
2
a
20
32
1a
2a
19
Faculty
61 16
19
1
49
2
2
1a
32
34
1b
1d
18
37
45
1d
2 29
1d
25
Damaris Lorenzo, MSc, PhD
78
45
Presidential Associate Professor
7
75
Department: Cell and Developmental Biology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
41
4
3
3
3
2
4
b
1f
41
421 Curie Boulevard
44 Biomedical Research Building 1112
Philadelphia, PA 19104
26
44 Biomedical Research Building 1112
Philadelphia, PA 19104
30
Office: (651) 283-0368
40 Lab: (215) 898-7886
18
f
40 Lab: (215) 898-7886
18
13
Education:
21 9 B.S. 2b (Biochemistry (summa cum laude)) c
2d University of Havana, 1999.
21 8 MSc 24 (Plant Molecular Biology) c
2d University of Havana, 2003.
21 8 PhD 40 (Molecular, Cell, Developmental Biology and Genetics) c
30 University of Minnesota, 2009.
c
3
27
5
3
3
92
Permanent link21 9 B.S. 2b (Biochemistry (summa cum laude)) c
2d University of Havana, 1999.
21 8 MSc 24 (Plant Molecular Biology) c
2d University of Havana, 2003.
21 8 PhD 40 (Molecular, Cell, Developmental Biology and Genetics) c
30 University of Minnesota, 2009.
c
2 29
21
1e
1d
24
2b
29
27
23
eb Damaris N. Lorenzo, Reginald J. Edwards, Anastasia L. Slavutsky: Spectrins: molecular organizers and targets of neurological disorders. Nat Rev Neurosci Jan 2023.
14a Creighton BA, Afriyie S, Ajit D, Casingal CR, Voos KM, Reger J, Burch AM, Dyne E, Bay J, Huang JK, Anton ES, Fu MM, Lorenzo DN.: Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. Elife 10: e69815, Nov 2021.
44b Cousin MA, Creighton BA, Breau KA, Spillmann RC, Torti E, Dontu S, Tripathi S, Ajit D, Edwards RJ, Afriyie S, Bay JC, Harper KM, Beltran AA, Munoz LJ, Falcon Rodriguez L, Stankewich MC, Person RE, Si Y, Normand EA, Blevins A, May AS, Bier L, Aggarwal V, Mancini GMS, van Slegtenhorst MA, Cremer K, Becker J, Engels H, Aretz S, MacKenzie JJ, Brilstra E, van Gassen KLI, van Jaarsveld RH, Oegema R, Parsons GM, Mark P, Helbig I, McKeown SE, Stratton R, Cogne B, Isidor B, Cacheiro P, Smedley D, Firth HV, Bierhals T, Kloth K, Weiss D, Fairley C, Shieh JT, Kritzer A, Jayakar P, Kurtz-Nelson E, Bernier RA, Wang T, Eichler EE, van de Laar IMBH, McConkie-Rosell A, McDonald MT, Kemppainen J, Lanpher BC, Schultz-Rogers LE, Gunderson LB, Pichurin PN, Yoon G, Zech M, Jech R, Winkelmann J; Undiagnosed Diseases Network; Genomics England Research Consortium, Beltran AS, Zimmermann MT, Temple B, Moy SS, Klee EW, Tan QK, Lorenzo DN.: Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. Nat Genet 2021.
cc Lorenzo DN.: Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons. Cytoskeleton (Hoboken) 2020.
140 Lorenzo DN, Badea A, Zhou R, Mohler PJ, Zhuang X, Bennett V.: βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. Proc Natl Acad Sci U S A 116: 15686-15695, Jul 2019.
f1 Lorenzo DN, Bennett V.: Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. Proc Natl Acad Sci U S A 114: 12743-12748, Nov 2017.
2c
7
1d
1f
Selected Publications
157 Voos KM, Tzeng J, P Patel, Rubinsky S, Choi HE, Pharr T, Sookram S, Baur JA, Soderblom EJ, Lorenzo DN. : Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity. Nature Communications 16(1): 7671, August 2025eb Damaris N. Lorenzo, Reginald J. Edwards, Anastasia L. Slavutsky: Spectrins: molecular organizers and targets of neurological disorders. Nat Rev Neurosci Jan 2023.
14a Creighton BA, Afriyie S, Ajit D, Casingal CR, Voos KM, Reger J, Burch AM, Dyne E, Bay J, Huang JK, Anton ES, Fu MM, Lorenzo DN.: Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. Elife 10: e69815, Nov 2021.
44b Cousin MA, Creighton BA, Breau KA, Spillmann RC, Torti E, Dontu S, Tripathi S, Ajit D, Edwards RJ, Afriyie S, Bay JC, Harper KM, Beltran AA, Munoz LJ, Falcon Rodriguez L, Stankewich MC, Person RE, Si Y, Normand EA, Blevins A, May AS, Bier L, Aggarwal V, Mancini GMS, van Slegtenhorst MA, Cremer K, Becker J, Engels H, Aretz S, MacKenzie JJ, Brilstra E, van Gassen KLI, van Jaarsveld RH, Oegema R, Parsons GM, Mark P, Helbig I, McKeown SE, Stratton R, Cogne B, Isidor B, Cacheiro P, Smedley D, Firth HV, Bierhals T, Kloth K, Weiss D, Fairley C, Shieh JT, Kritzer A, Jayakar P, Kurtz-Nelson E, Bernier RA, Wang T, Eichler EE, van de Laar IMBH, McConkie-Rosell A, McDonald MT, Kemppainen J, Lanpher BC, Schultz-Rogers LE, Gunderson LB, Pichurin PN, Yoon G, Zech M, Jech R, Winkelmann J; Undiagnosed Diseases Network; Genomics England Research Consortium, Beltran AS, Zimmermann MT, Temple B, Moy SS, Klee EW, Tan QK, Lorenzo DN.: Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. Nat Genet 2021.
cc Lorenzo DN.: Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons. Cytoskeleton (Hoboken) 2020.
140 Lorenzo DN, Badea A, Zhou R, Mohler PJ, Zhuang X, Bennett V.: βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. Proc Natl Acad Sci U S A 116: 15686-15695, Jul 2019.
f1 Lorenzo DN, Bennett V.: Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. Proc Natl Acad Sci U S A 114: 12743-12748, Nov 2017.
2c
4d
22
22
7
10
a
a
2
2
19
18
10
22
10
11
c
5b © The Trustees of the University of Pennsylvania | Site best viewed a in a supported browser. | Site Design: 57 PMACS Web Team. 3 22
10