Faculty

William H. Peranteau, MD

Professor of Surgery at the Children's Hospital of Philadelphia

Department: Surgery

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Division of Pediatric General, Thoracic & Fetal Surgery
The Children's Hospital of Philadelphia
Center for Fetal Research
3615 Civic Center Blvd
Abramson Research Center, Rm 1116E
Philadelphia, PA 19104

Office: 215-590-2730
Fax: 215-590-4875
Lab: 215-590-4810

Email:
peranteauw@chop.edu

Education
BA (molecular biology)
Princeton University, Princeton, NJ, 1997.
MD
University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

I have an interest in fetal development as it relates to the potential understanding of and fetal intervention for congenital anomalies. Specifically, I have had a deep interest and significant experience evaluating in utero hematopoietic stem cell transplantation in the murine and canine model. These studies provide interesting information and address basic questions on the development of the fetal hematopoietic niche. One of the main goals of my research is a better understanding of the barriers to successful allogeneic in utero bone marrow transplantation. Allogeneic in utero bone marrow transplantation would allow for nonmyeloablative unmatched transplants without the need for immunosuppression and thus holds significant clinical promise for the treatment of hemoglobinopathies, such as Sickle Cell disease.

Selected Publications

Luks VL, Berkowitz CL, Puc M, Peranteau WH: Congenital lobar emphysema and bronchial atresia. Fetal and Neonatal Surgery and Medicine. Crombleholme TM, Lim FY, Peiro JL, Rintoul NE, Simpson LL (eds.). New York: McGraw Hill Medical, Page: 459-466, 2025 Notes: Part IV, Section C, Chap. 35.

David AL, Peranteau WH: Gene therapy. Fetal and Neonatal Surgery and Medicine. Crombleholme TM, Lim FY, Peiro JL, Rintoul NE, Simpson LL (eds.). New York: McGraw Hill Medical, Page: 1037-1058, 2025 Notes: Part IV, Section M, Chap. 84.

di Natale A, Flohr S, Mathew L, Katterman C, Gallagher C, Reynolds TA, Gebb JS, Panitch HB, Oliver ER, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL: Neonatal outcomes of multiple congenital thoracic lesions. Fetal Diagnosis & Therapy 52(2): 194-206, 2025 Notes: Epub Sept. 7, 2024.

Kus NJ, Carpenter MD, Choi RB, Dumitru AMG, Mudreac A, Peranteau WH: Systemic delivery of LNP mRNA in utero permits editing in a mouse model of spinal muscular atrophy. Journal of the American College of Surgeons 239(5 Suppl 1): S362-S363, Nov. 2024 Notes: Presented at the Owen H. Wangensteen Scientific Forum at the 2024 American College of Surgeons Clinical Congress, San Francisco, CA, Oct. 2024.

Mudreac A, Carpenter MD, Perez AD, Kus NJ, Peranteau WH: In utero delivery of CRISPR/Cas-9 via lipid nanoparticles for treatment of Friedreich's Ataxia. Journal of the American College of Surgeons 239(5 Suppl 1): S351, Nov. 2024 Notes: Presented at the Owen H. Wangensteen Scientific Forum at the 2024 American College of Surgeons Clinical Congress, San Francisco, CA, Oct. 2024.

Riley JS, Berkowitz CL, Luks VL, Dave A, Cyril-Olutayo MC, Pogoriler J, Flake AW, Abdulmalik O, Peranteau WH: Immune modulation permits tolerance and engraftment in a murine model of late-gestation transplantation. Blood Advances 8(17): 4523-4538, Sept. 10 2024.

Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ: Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab On a Chip 24(16): 3790-3801, Aug. 6 2024.

Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ*, Peranteau WH*: In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences USA 121(32): e2400783121, Aug. 6 2024 Notes: * co-senior authors; Epub July 30, 2024.

Riley JS, Luks VL, Berkowitz CL, Dumitru AM, Kus NJ, Dave A, Menon P, De Paepe ME, Jain R, Li L, Dugoff L, Teefey CP, Alameh MG, Zoltick PW, Peranteau WH: Preexisting maternal immunity to AAV but not Cas9 impairs in utero gene editing in mice. Journal of Clinical Investigation 134(12): e179848, May 9 2024.

Dumitru AM, Carpenter M, Whittaker M, Berkowitz C, Luks VL, Kus N, Choi R, Archer NF, Johnston W, Biswas A, Li JYS, Fan Y, Wang X, Alameh MG, Chan J, Musunuru K, Peranteau W: In Utero and Postnatal Base Editing for a Metabolic Liver Disease in Mice and Nonhuman Primates. Molecular Therapy 32(4 Suppl 1): 53, Apr. 2024 Notes: Presented at the 27th Annual Meeting of the American Society of Gene & Cell Therapy, Baltimore, MD, May 2024.