Saar I Gill, MD, PhD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
Room 8-101
Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: (215) 573-4015
Lab: (215) 573-4015
MBBS (medicine)
University of Melbourne, 1999.
PhD (immunology)
University of Melbourne, 2011.
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Description of Clinical Expertise

Blood and Marrow Transplantation
Myelodysplastic Syndromes
Myeloproliferative Neoplasms
Lymphoproliferative Neoplasms
Bone Marrow Failure

Description of Research Expertise

Tumor Immunology
Chimeric Antigen Receptor T cells
Mouse Models of Human Leukemia
Murine Xenografts
Adoptive Cellular Therapy
Genetic Engineering of T cells
Flow Cytometry

Selected Publications

Nathan Singh # 1 2 3 , Noelle V Frey # 4 , Boris Engels # 5 , David M Barrett 6 7 , Olga Shestova 8 , Pranali Ravikumar 8 , Katherine D Cummins 8 , Yong Gu Lee 8 , Raymone Pajarillo 8 , Inkook Chun 8 , Amy Shyu 5 , Steven L Highfill 5 , Andrew Price 5 , Linlin Zhao 5 , Liaomin Peng 5 , Brian Granda 5 , Melissa Ramones 5 , Xueqing Maggie Lu 9 , David A Christian 10 , Jessica Perazzelli 6 , Simon F Lacey 8 11 12 , Nathan H Roy 12 13 , Janis K Burkhardt 12 13 , Florent Colomb 14 , Mohammad Damra 14 , Mohamed Abdel-Mohsen 14 , Ting Liu 15 , Dongfang Liu 15 16 , Daron M Standley 17 , Regina M Young 8 , Jennifer L Brogdon 5 , Stephan A Grupp 6 , Carl H June 4 8 12 , Shannon L Maude # 6 , Saar Gill # 4 8 , Marco Ruella # 18 19: Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells. Nature Medicine May 2021.

Anderson NR, Minutolo NG, Gill S, Klichinsky M.: Macrophage-Based Approaches for Cancer Immunotherapy. Cancer Res 81: 1201-1208, Mar 2021.

Kim GYG, Burns J, Freyer CW, Hamilton KW, Frey NV, Gill SI, Hexner EO, Luger SM, Mangan JK, Martin ME, McCurdy SR, Perl AE, Porter DL, Schuster MG, Stadtmauer EA, Loren AW: Risk of invasive fungal infections in patients with high-risk MDS and AML receiving hypomethylating agents. Am J Hematol 95(7): 792-798, Jul 2020

Frey NV, Gill S, Hexner EO, Schuster S, Nasta S, Loren A, Svoboda J, Stadtmauer E, Landsburg DJ, Mato A, Levine BL, Lacey SF, Melenhorst JJ, Veloso E, Gaymon A, Pequignot E, Shan X, Hwang WT, June CH, Porter DL: Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia. J Clin Oncol Page: JCO1903237, Apr 16 2020 Notes: doi: 10.1200/JCO.19.03237.

Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, Yashiro-Ohtani Y, Kenderian SS, Kim MY, O'Connor RS, Wallace SR, Kozlowski MS, Marchione DM, Shestov M, Garcia BA, June CH, Gill S. : Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol 38(8): 947-953, Aug 2020.

Brian J Ball, Christopher A Famulare, Eytan M Stein, Martin S Tallman, Andriy Derkach, Mikhail Roshal, Saar I Gill, Benjamin M Manning, Jamie Koprivnikar, James McCloskey, Rebecca Testi, Thomas Prebet, Najla H Al Ali, Eric Padron, David A Sallman, Rami S Komrokji, Aaron D Goldberg : Venetoclax and hypomethylating agents (HMAs) induce high response rates in MDS, including patients after HMA therapy failure. Blood Adv 4(13): 2866-2870, Jul 14 2020.

Finck A, Gill SI, June CH.: Cancer immunotherapy comes of age and looks for maturity. Nat Commun 11: 3325, Jul 2020.

Freyer CW, Carulli A, Ganetsky A, Hughes ME, Krause TM, Timlin C, Frey NV, Gill SI, Hexner EO, Loren AW, Mangan JK, Martin ME, McCurdy SR, Perl AE, Pratz K, Porter DL, Luger SM.: Venous thromboembolism following pegaspargase in adults receiving antithrombin supplementation. Leuk Lymphoma Page: 1-8, Jun 1 2020 Notes: doi: 10.1080/10428194.2020.1765239.

Mardiana S, Gill S.: CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions. Front Oncol 10: 697, May 6 2020 Notes: doi: 10.3389/fonc.2020.00697.

Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M.: Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction. Cancer Discov 10(4): 552-567, Apr 2020.

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Last updated: 09/14/2021
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