Faculty

Beatriz M. Carreno, PhD

faculty photo
Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
PCAM South Tower, 8th Floor
3400 Civic Blvd
Philadelphia, PA 19104
Office: 215-573-7044
Lab: 215-573-4931
Education:
BS
Universidad Simon Bolivar, Caracas, Venezuela, 1981.
PhD (Microbiology)
Georgetown University School of Medicine, 1989.
Permanent link
 
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Selected Publications

Bhatta, M., Shenoy, G.N., Loyall, J.L., Gray, B.D., Bapardekar, M., Conway, A., Minderman, H., Kelleher, R.J. Jr, Carreno, B.M., Linette, G., Shultz, L.D., Odunsi, K., Balu-Iyer, S.V., Pak, K.Y., Bankert, R.B.: Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments. J Immunother Cancer 9(10): e003148, Oct 2021.

Bear, A.S., Blanchard, T., Cesare, J., Ford, M.J., Richman, L.P., Xu, C., Baroja, M.L., McCuaig, S., Costeas, C., Gabunia, K., Scholler, J., Posey, A.D. Jr, O'Hara, M.H., Smole, A., Powell, D.J. Jr, Garcia, B.A., Vonderheide, R.H., Linette, G.P., Carreno, B.M.: Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting. Nat Commun 12(1): 4365, Jul 2021.

Li, L., Zhang, X., Wang, X., Kim, S.W., Herndon, J.M., Becker-Hapak, M.K., Carreno, B.M., Myers, N.B., Sturmoski, M.A., McLellan, M.D., Miller, C.A., Johanns, T.M., Tan, B.R., Dunn, G.P., Fleming, T.P., Hansen, T.H., Goedegebuure, S.P., Gillanders, W.E.: Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation. Genome Med 13(1): 56, Apr 2021.

Shenoy, G.N., Greene, C.J., Bhatta, M., Baroja, M..L, Loyall, J.L., Balu-Iyer, S.V., Kelleher, R.J. Jr, Carreno, B.M., Linette, G.P., Shultz, L.D., Bankert, R.B.: Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform. Clin Transl Immunology 10(2): e1246, Feb 2021.

Wells D.K., van Buuren M.M., Dang K.K., Hubbard-Lucey V.M., Sheehan K.C.F., Campbell K.M., Lamb A., Ward J.P., Sidney J., Blazquez A.B., Rech A.J., Zaretsky J.M., Comin-Anduix B., Ng A.H.C., Chour W., Yu T.V., Rizvi H., Chen J.M., Manning P., Steiner G.M., Doan X.C., Merghoub T., Guinney J., Kolom A., Selinsky C., Ribas A., Hellmann M.D., Hacohen N., Sette A., Heath J.R., Bhardwaj N., Ramsdell F., Schreiber R.D., Schumacher T.N., Kvistborg P., Defranoux N.A.: Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell 183(3): 818-834, Oct 2020.

Ritz, C., Meng, W., Stanley, N.L., Baroja, M.L., Xu, C., Yan, P., Huang, A.C., Hausler, R., Nicholas, P., Fan, J.M., Lieberman, D., Carreno, B.M., Luning, Prak, E.T., Olson, T.S., Babushok, D.V.: Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Blood Adv 4(7): 1378-1382, Apr 2020.

Stadtmauer, E.A., Fraietta, J.A., Davis, M.M., Cohen, A.D., Weber, K.L., Lancaster, E., Mangan, P.A., Kulikovskaya, I., Gupta, M., Chen, F., Tian, L., Gonzalez, V.E., Xu, J., Jung, I.Y., Melenhorst, J.J., Plesa, G., Shea, J., Matlawski, T., Cervini, A., Gaymon, A.L., Desjardins, S., Lamontagne, A., Salas-Mckee, J., Fesnak, A., Siegel, D.L., Levine, B.L., Jadlowsky, J.K., Young, R.M., Chew, A., Hwang, W.T., Hexner, E.O., Carreno, B.M., Nobles, C.L., Bushman, F.D., Parker, K.R., Qi, Y., Satpathy, A.T., Chang, H.Y., Zhao, Y., Lacey, S.F., June, C.H.: CRISPR-engineered T cells in patients with refractory cancer. Science 367(6481): eaba7365, Feb 2020.

Linette, G.P., Becker-Hapak, M., Skidmore, Z.L., Baroja, M.B., Xu, C., Hundal, J., Spencer, D.H., Fu, W., Cummins, C., Robnett, M., Kaabinejadian, S., Hildebrand, W.H., Magrini, V., Demeter, R., Krupnick, A.S., Griffith, O.L., Griffith, M., Mardis, E.R., Carreno, B.M.: Immunological Ignorance is an enabling feature of the oligo-clonal T cell response to melanoma antigens. PNAS 116(47): 23662-23670, Nov 2019.

Linette, G.P., Carreno, B.M.: Tumor-Infiltrating Lymphocytes in the Checkpoint Inhibitor Era. Curr Hematol Malig Rep 14(4): 286, 2019.

Ghasemi, R., Lazear, E., Wang, X., Arefanian, S., Zheleznyak, A., Carreno, B.M., Higashikubo, R., Gelman, A.E., Kreisel, D., Fremont, D.H., Krupnick, A.S.: Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy. Nat Commun 7: 12878, Sept 2016.

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Last updated: 07/27/2022
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