Faculty

Caroline Diorio, MD, MSTR, FRCPC, FAAP

Assistant Professor of Pediatrics (Oncology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
Division of Oncology
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104

Education:
BSc (Biology and Psychology)
Wilfrid Laurier University, 2010.
MD (Medicine)
University of Toronto Faculty of Medicine, 2014.
MTR (Translational Research)
University of Pennsylvania School of Medicine, 2021.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

High risk leukemia, relapsed/refractory T-ALL, HLH, CART

Description of Research Expertise

Serum proteomics, immune dysregulation, T-cell ALL immunotherapy

Selected Publications

Frank-Kamenetskii AM, Klinghoffer H, Varghese JA, Dang V, Morrissette J, Fraietta JA, Diorio C, Burkhardt JK, Canna S: Modeling the HLH immune synapse uncovers critical roles for IS termination, cytokine intensity, and target cell death. Blood Page: 2024027179, May 13 2025.

Shraim R, Diorio C, Canna SW, Macdonald-Dunlop E, Bassiri H, Martinez Z, Mälarstig A, Abbaspour A, Teachey DT, Lindell RB, Behrens EM.: A Method for Comparing Proteins Measured in Serum and Plasma by Olink® Proximity Extension Assay. Mol Cell Proteomics Page: 101000, May 27 2025.

Newman H, Lee SHR, Pölönen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes AD, Hunger SP, Loh ML, Martinez Z, McCoy MF, Mullen CG, Pounds SB, Raetz E, Seffernick AE, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang'ondu R, Winestone LE, Winter SS, Wood BL, Wu G, Xu J, Yang W, Mullighan CG, Yang JJ, Bona K, Teachey DT: Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia. Blood Cancer Discov May 28 2025.

Myers RM*, DiNofia AM*, Li Y, Diorio C, Liu H, Wertheim G, Fraietta JA, Gonzalez VE, Plesa G, Siegel DL, Iannone E, Shinehous L, Brodon JL, Taylor C, Jadlowsky JK, Hexner EO, Engels B, Baniewicz D, Callahan C, Ruella M, Aplenc R, Leahy AB, McClory SE, Rheingold SR, Wray L, June C, Maude SL, Frey NV, Grupp SA: CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy. J Immunother Cancer 13(4): e011549, April 17 2025.

Xu J, Sussman JH, Yang A, Yoshimura S, Hu J, Chen C, Vincent TL, Bandyopadhyay S, Li EY, Lim TL, Elghawy O, Barsouk A, Karanfilovski D, Wald SL, Chen GM, Wu DW, Newman H, Li A, Chen CH, Bernt KM, Wood BL, Winter SS, Dunsmore KP, Raetz EA, Devidas M, Pounds SB, Loh ML, Hunger SP, Chiang M, Diorio C, Giacomo DD, Pölönen P, Mullighan CG, Yang JJ, Tan K, Sun Y, Teachey DT: STAT1-driven interferon signatures are associated with JAK inhibitor sensitivity in T-ALL. Blood March 2025.

Chen C, Xu J, Sussman J, Vincent T, Tumulty J, Yoshimura S, Alikarami F, Yu W, Ding Y, Chen C, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng JJ, Pölönen P, Newman H, Wood B, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang J, Bernt KM, Teachey DT, TanK : Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood March 2025.

Diorio C, Teachey DT, Grupp SA: Allogeneic chimeric antigen receptor cell therapies for cancer: progress made and remaining roadblocks. Nat Rev Clin Oncol November 15 2024.

Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer November 25 2024.

Diorio C*, Hernandez-Miyares L*, Espinoza DA, Banwell BL, Bar-Or A, DiNofia AM, Barz Leahy A, Martinez Z, Myers RM, Hopkins SE, Rheingold SR, Teachey DT, Viaene AN, Wray LM, Maude SL, Grupp SA, McGuire JL: Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents. Blood 144(13): 1387-1398, September 26 2024.

Carol HA, Mayer AS, Zhang MS, Dang V, Varghese J, Martinez Z, Schneider C, Baker JE, Tsoukas P, Behrens EM, Cron RQ, Diorio C, Henderson LA, Schulert G, Lee P, Kernan KF, Canna SW: Hyperferritinemia Screening to Aid Identification and Differentiation of Patients with Hyperinflammatory Disorders. J Clin Immunol 45(1): 4, September 12 2024.