Faculty

Caroline Diorio, MD, MSTR, FRCPC, FAAP

Assistant Professor of Pediatrics (Oncology)

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
Division of Oncology
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104

Education:
BSc (Biology and Psychology)
Wilfrid Laurier University, 2010.
MD (Medicine)
University of Toronto Faculty of Medicine, 2014.
MTR (Translational Research)
University of Pennsylvania School of Medicine, 2021.

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

High risk leukemia, relapsed/refractory T-ALL, HLH, CART

Description of Research Expertise

Serum proteomics, immune dysregulation, T-cell ALL immunotherapy

Selected Publications

Xu J, Sussman JH, Yang A, Yoshimura S, Hu J, Chen C, Vincent TL, Bandyopadhyay S, Li EY, Lim TL, Elghawy O, Barsouk A, Karanfilovski D, Wald SL, Chen GM, Wu DW, Newman H, Li A, Chen CH, Bernt KM, Wood BL, Winter SS, Dunsmore KP, Raetz EA, Devidas M, Pounds SB, Loh ML, Hunger SP, Chiang M, Diorio C, Giacomo DD, Pölönen P, Mullighan CG, Yang JJ, Tan K, Sun Y, Teachey DT: STAT1-driven interferon signatures are associated with JAK inhibitor sensitivity in T-ALL. Blood March 2025.

Chen C, Xu J, Sussman J, Vincent T, Tumulty J, Yoshimura S, Alikarami F, Yu W, Ding Y, Chen C, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng JJ, Pölönen P, Newman H, Wood B, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang J, Bernt KM, Teachey DT, TanK : Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome. Blood March 2025.

Diorio C, Teachey DT, Grupp SA: Allogeneic chimeric antigen receptor cell therapies for cancer: progress made and remaining roadblocks. Nat Rev Clin Oncol November 15 2024.

Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Nat Cancer November 25 2024.

Diorio C*, Hernandez-Miyares L*, Espinoza DA, Banwell BL, Bar-Or A, DiNofia AM, Barz Leahy A, Martinez Z, Myers RM, Hopkins SE, Rheingold SR, Teachey DT, Viaene AN, Wray LM, Maude SL, Grupp SA, McGuire JL: Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents. Blood 144(13): 1387-1398, September 26 2024.

Gallo PM, Kim J, McNerney KO, Diorio C, Foley C, Kagami L, Wagner K, Petrosa WL, Conlon H, Gollomp KL, Canna SW, Seif AE, Conrad MA, Kelsen JR, Romberg N, Bassiri H, Sullivan KE, Teachey DT, Paessler ME, Behrens EM, Lambert MP.: Serum Cytokine Panels in Pediatric Clinical Practice. J Allergy Clin Immunol September 18 2024.

Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R.: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature September 25 2024.

Carol HA, Mayer AS, Zhang MS, Dang V, Varghese J, Martinez Z, Schneider C, Baker JE, Tsoukas P, Behrens EM, Cron RQ, Diorio C, Henderson LA, Schulert G, Lee P, Kernan KF, Canna SW: Hyperferritinemia Screening to Aid Identification and Differentiation of Patients with Hyperinflammatory Disorders. J Clin Immunol 45(1): 4, September 12 2024.

Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT: The genomic basis of childhood T-lineage acute lymphoblastic leukaemia. Nature 632(8027): 1082-1091, August 14 2024.

Perna F, Parekh S, Diorio C, Smith M, Subklewe M, Mehta R, Locke FL, Shah NN: CAR T-cell toxicities: from bedside to bench, how novel toxicities inform laboratory investigations. Blood Adv 8(16): 4348-4358, August 27 2024.