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Matthew S Kayser, MD, PhD
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Karl E. Rickels Associate Professor of Psychiatry II
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Department: Psychiatry
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Graduate Group Affiliations
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- Cell and Molecular Biology 6a
- Pharmacology 64
- Neuroscience e
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Contact information
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415 Curie Blvd
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Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 2158988268
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Education:
21 8 ScB 19 (Neuroscience) c
29 Brown University, 2000.
21 c MD, PhD 19 (Neuroscience) c
46 University of Pennsylvania School of Medicine, 2009.
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Permanent link21 8 ScB 19 (Neuroscience) c
29 Brown University, 2000.
21 c MD, PhD 19 (Neuroscience) c
46 University of Pennsylvania School of Medicine, 2009.
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45 sleep, synapse, development, drosophila, psychiatry, behavior
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1c Research interests:
158 We study how neural circuits give rise to complex behaviors, and how dysfunction of neural processes can cause mental illness. Our particular focus is in understanding how sleep -- a highly conserved behavior whose core function remains a mystery -- contributes to sculpting brain circuits during development and in other times of life.
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3b Please visit www.kayserlab.com for more information
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1d Research techniques:
55 drosophila genetics, behavioral assays, molecular biology, imaging approaches
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19 Research summary:
33d Sleep abnormalities are pervasive across nearly all psychiatric disorders, and disrupted sleep early in life has been linked to mental illness in adulthood. Work in the Kayser Lab stands to connect this fundamental behavior – sleep – to both pathogenesis and treatment of neuropsychiatric disease. We primarily utilize the powerful genetic system Drosophila melanogaster (the fruit fly). The fly provides unparalleled neurogenetic approaches towards unraveling the neural logic of complex behaviors. In addition, genetic and molecular insights from Drosophila have repeatedly translated to higher organisms, even humans. The Kayser Lab is a "question-driven" lab. We use or develop any approaches necessary to further our understanding of biological processes that, when awry, contribute to neuropsychiatric disease.
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18 Projects include
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68 1. How does sleep early in life affect brain development and, ultimately, normal adult function?
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69 2. What role does sleep play in promoting the formation of new synaptic connections in the brain?
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42 2. How do disruptions to sleep impact aggressive behaviors?
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Description of Clinical Expertise
a8 Dr. Kayser is a practicing psychiatrist at the University of Pennsylvania School of Medicine, specializing in issues related to sleep and mental health.71
Description of Research Expertise
1c Key words:45 sleep, synapse, development, drosophila, psychiatry, behavior
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1c Research interests:
158 We study how neural circuits give rise to complex behaviors, and how dysfunction of neural processes can cause mental illness. Our particular focus is in understanding how sleep -- a highly conserved behavior whose core function remains a mystery -- contributes to sculpting brain circuits during development and in other times of life.
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3b Please visit www.kayserlab.com for more information
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1d Research techniques:
55 drosophila genetics, behavioral assays, molecular biology, imaging approaches
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19 Research summary:
33d Sleep abnormalities are pervasive across nearly all psychiatric disorders, and disrupted sleep early in life has been linked to mental illness in adulthood. Work in the Kayser Lab stands to connect this fundamental behavior – sleep – to both pathogenesis and treatment of neuropsychiatric disease. We primarily utilize the powerful genetic system Drosophila melanogaster (the fruit fly). The fly provides unparalleled neurogenetic approaches towards unraveling the neural logic of complex behaviors. In addition, genetic and molecular insights from Drosophila have repeatedly translated to higher organisms, even humans. The Kayser Lab is a "question-driven" lab. We use or develop any approaches necessary to further our understanding of biological processes that, when awry, contribute to neuropsychiatric disease.
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18 Projects include
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68 1. How does sleep early in life affect brain development and, ultimately, normal adult function?
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69 2. What role does sleep play in promoting the formation of new synaptic connections in the brain?
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42 2. How do disruptions to sleep impact aggressive behaviors?
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19a Kyla Mace, Amber Zimmerman, Alessandra Chesi, Fusun Doldur-Balli, Hayle Kim, Erika Almeraya Del Valle, Jeffrey B. Rosa, Allan I. Pack, Struan F.A. Grant4, Matthew S. Kayser: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2. Nature Communications in press 2025.
103 Wani AR, Chowdhury B, Luong J, Chaya GM, Patel K, Isaacman-Beck J, Kayser MS, Syed MH.: Stem cell-specific ecdysone signaling regulates the development of dorsal fan-shaped body neurons and sleep homeostasis. 11 Curr Biol. 2 1e Oct 2024.
cc Poe AR, Zhu L, Tang SH, Valencia E, Kayser MS.: Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development. eLife. July 2024.
127 Perlegos AE, Durkin J, Belfer SJ, Rodriguez A, Shcherbakova O, Park K, Luong J, Bonini NM, Kayser MS.: TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance. Science Advances 12(10), Jan 2024.
130 Poe AR, Zhu L, McClanahan P, Szuperak M, Anafi RC, Scholl B, Thum AS, Cavanaugh DJ, Kayser MS. : Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila. Science Advances 9(36), September 2023.
110 Durkin J, Poe AR, Belfer SJ, Rodriguez A, Tang SH, Walker JA, Kayser MS.: Neurofibromin 1 regulates early developmental sleep in Drosophila. Neurobiol Sleep Circadian Rhythms 15(100101), August 2023.
118 Gong NN, Luong HNB, Dang AH, Mainwaring B, Shields E, Schmeckpeper K, Bonasio R, Kayser MS. : Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila. Curr Bio 32(18), Sept 2022.
146 Gehrman P, Gunter P, Findley J, Frasso R, Weljie AM, Kuna ST, Kayser MS: Randomized non-inferiority trial of telehealth delivery of cognitive behavioral treatment of insomnia compared to in-person care. Journal of Clinical Psychiatry 82(5), August 2021.
131 Goldschmied JR, Sengupta A, Sharma A, Taylor L, Morales KN, Thase ME, Weljie A, Kayser MS: Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression. Psychopharmacology Bulletin 51(3): 50-64, June 2021.
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Selected Publications
e6 Gehrman P, McDonald T, Barilla H, Lee R, Harrell M, Kayser MS: Insomnia Disorder and CSF Markers of Dementia. Journal of Alzheimer’s Disease in press 2025.19a Kyla Mace, Amber Zimmerman, Alessandra Chesi, Fusun Doldur-Balli, Hayle Kim, Erika Almeraya Del Valle, Jeffrey B. Rosa, Allan I. Pack, Struan F.A. Grant4, Matthew S. Kayser: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2. Nature Communications in press 2025.
103 Wani AR, Chowdhury B, Luong J, Chaya GM, Patel K, Isaacman-Beck J, Kayser MS, Syed MH.: Stem cell-specific ecdysone signaling regulates the development of dorsal fan-shaped body neurons and sleep homeostasis. 11 Curr Biol. 2 1e Oct 2024.
cc Poe AR, Zhu L, Tang SH, Valencia E, Kayser MS.: Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development. eLife. July 2024.
127 Perlegos AE, Durkin J, Belfer SJ, Rodriguez A, Shcherbakova O, Park K, Luong J, Bonini NM, Kayser MS.: TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance. Science Advances 12(10), Jan 2024.
130 Poe AR, Zhu L, McClanahan P, Szuperak M, Anafi RC, Scholl B, Thum AS, Cavanaugh DJ, Kayser MS. : Developmental emergence of sleep rhythms enables long-term memory capabilities in Drosophila. Science Advances 9(36), September 2023.
110 Durkin J, Poe AR, Belfer SJ, Rodriguez A, Tang SH, Walker JA, Kayser MS.: Neurofibromin 1 regulates early developmental sleep in Drosophila. Neurobiol Sleep Circadian Rhythms 15(100101), August 2023.
118 Gong NN, Luong HNB, Dang AH, Mainwaring B, Shields E, Schmeckpeper K, Bonasio R, Kayser MS. : Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila. Curr Bio 32(18), Sept 2022.
146 Gehrman P, Gunter P, Findley J, Frasso R, Weljie AM, Kuna ST, Kayser MS: Randomized non-inferiority trial of telehealth delivery of cognitive behavioral treatment of insomnia compared to in-person care. Journal of Clinical Psychiatry 82(5), August 2021.
131 Goldschmied JR, Sengupta A, Sharma A, Taylor L, Morales KN, Thase ME, Weljie A, Kayser MS: Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression. Psychopharmacology Bulletin 51(3): 50-64, June 2021.
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