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Lewis A. Chodosh, M.D., Ph.D.
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Perelman Professor in Cancer Biology
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Department: Cancer Biology
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Graduate Group Affiliations
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Contact information
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614 BRB II/III
32 421 Curie Blvd.
Philadelphia, PA 19104
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32 421 Curie Blvd.
Philadelphia, PA 19104
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Office: (215) 898-1321
34 Fax: (215) 573-6725
34 Lab: (215) 898-0006
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34 Fax: (215) 573-6725
34 Lab: (215) 898-0006
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Publications
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Education:
21 9 B.S. 30 (Molecular Biophysics & Biochemistry) c
28 Yale University, 1981.
21 a Ph.D. 19 (Biochemistry) c
3e Massachusetts Institute of Technology, 1988.
21 9 M.D. c
2f Harvard Medical School, 1989.
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21 9 B.S. 30 (Molecular Biophysics & Biochemistry) c
28 Yale University, 1981.
21 a Ph.D. 19 (Biochemistry) c
3e Massachusetts Institute of Technology, 1988.
21 9 M.D. c
2f Harvard Medical School, 1989.
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Links
99 Search PubMed for articles
47 Cell and Molecular Biology graduate group faculty webpage.
66 Department of Cancer Biology
83 Abramson Family Cancer Research Institute
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Permanent link99 Search PubMed for articles
47 Cell and Molecular Biology graduate group faculty webpage.
66 Department of Cancer Biology
83 Abramson Family Cancer Research Institute
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2 29
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39 Mechanisms of cancer development and progression.
27 Tumor dormancy and recurrence.
17 Cancer biology.
2c Genomics and computational biology.
18 Cancer genetics.
35 Oncogene and tumor suppressor gene function.
3d Genetically engineered mouse models for human cancer.
16 Breast cancer.
16 Endocrinology.
25 Stem cells in cancer biology.
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1e Non-invasive imaging.
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a5 Key words: Cancer biology, cancer genetics, genomics, computational biology, oncogenes, targeted therapy, functional imaging, stem cells, development.
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26 Description of Research
513 Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models, patient samples and computational biology to study the mechanisms by which breast cancers develop, become resistant to therapy, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology. These approaches employ molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in tumor biology using genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation.
8
8
20 Rotation Projects
4d Rotation projects are available in each of the main areas of the lab.
8
1d Lab personnel:
2b Sarah Acolatse – Graduate Student
2f George Belka - Research Project Manager
25 Brian Benz - Graduate Student
26 Yan Chen - Research Specialist
33 Beth Chislock – Sr. Research Investigator
2b Jewell Graves - Research Specialist
2a Katherine Huang - Graduate Student
2b Morgan Kuczler – Graduate Student
52 Jennifer McCallum - Lab Manager (Jennifer.McCallum@pennmedicine.upenn.edu)
32 Heather Martin - Sr. Research Investigator
2c Nathan Mears - Lab Animal Technician
36 Tien-chi Pan – Staff Computational Biologist
34 Dhruv Pant – Staff Computational Biologist
2d Matt Paul – Postdoctoral Researcher
33 Ashvathi Raghavakaimal – Graduate Student
37 Emily Shea – Combined Degree (MD-PhD) Student
2f Amulya Sreekumar – Research Associate
27 Chris Sterner - Project Manager
2b Jianping Wang - Research Specialist
8
8
8
3f Assistant Director, Administrative and Faculty Affairs:
16 Katelyn Carlin
19 kwichert@upenn.edu
65
1a 29
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Description of Research Expertise
2b Research Interests39 Mechanisms of cancer development and progression.
27 Tumor dormancy and recurrence.
17 Cancer biology.
2c Genomics and computational biology.
18 Cancer genetics.
35 Oncogene and tumor suppressor gene function.
3d Genetically engineered mouse models for human cancer.
16 Breast cancer.
16 Endocrinology.
25 Stem cells in cancer biology.
8
8
1e Non-invasive imaging.
9
a5 Key words: Cancer biology, cancer genetics, genomics, computational biology, oncogenes, targeted therapy, functional imaging, stem cells, development.
8
26 Description of Research
513 Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models, patient samples and computational biology to study the mechanisms by which breast cancers develop, become resistant to therapy, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology. These approaches employ molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in tumor biology using genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation.
8
8
20 Rotation Projects
4d Rotation projects are available in each of the main areas of the lab.
8
1d Lab personnel:
2b Sarah Acolatse – Graduate Student
2f George Belka - Research Project Manager
25 Brian Benz - Graduate Student
26 Yan Chen - Research Specialist
33 Beth Chislock – Sr. Research Investigator
2b Jewell Graves - Research Specialist
2a Katherine Huang - Graduate Student
2b Morgan Kuczler – Graduate Student
52 Jennifer McCallum - Lab Manager (Jennifer.McCallum@pennmedicine.upenn.edu)
32 Heather Martin - Sr. Research Investigator
2c Nathan Mears - Lab Animal Technician
36 Tien-chi Pan – Staff Computational Biologist
34 Dhruv Pant – Staff Computational Biologist
2d Matt Paul – Postdoctoral Researcher
33 Ashvathi Raghavakaimal – Graduate Student
37 Emily Shea – Combined Degree (MD-PhD) Student
2f Amulya Sreekumar – Research Associate
27 Chris Sterner - Project Manager
2b Jianping Wang - Research Specialist
8
8
8
3f Assistant Director, Administrative and Faculty Affairs:
16 Katelyn Carlin
19 kwichert@upenn.edu
65
Description of Clinical Expertise
1e Endocrinology.1a 29
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209 Winkels RM, Sturgeon KM, Kallan MJ, Dean LT, Zhang Z, Evangelisti M, Brown JC, Sarwer DB, Troxel AB, Denlinger C, Laudermilk M, Fornash A, DeMichele A, Chodosh LA and Schmitz KH: The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema. Contemporary Clinical Trials 61: 63-72, 2017.
124 Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ and Chodosh LA: Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. Journal of Clinical Investigation 125: 2484-96, 2015.
10b Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA: Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research 74: 7583-7598, 2014.
101 Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery 4: 790-803, 2014.
15f Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA: Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24: 30-44, 2013.
159 Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA: Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development 26: 2154-2168, 2012.
118 Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.
16f Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation Cell Metabolism 4: 475-490, 2006.
121 Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notarfrancesco K, Cardiff RD and Chodosh LA: The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.
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Selected Publications
1b8 Maxwell KN, Soucier-Ernst D, Tahirovic E, Troxel AB, Clark C, Feldman M, Colameco C, Kakrecha B, Langer M, Lieberman D, Morrissette JJD, Paul MR, Pan TC, Yee S, Shih N, Carpenter E, Chodosh LA and DeMichele A: Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer. Breast Cancer Research and Treatment 164: 627-638, 2017.209 Winkels RM, Sturgeon KM, Kallan MJ, Dean LT, Zhang Z, Evangelisti M, Brown JC, Sarwer DB, Troxel AB, Denlinger C, Laudermilk M, Fornash A, DeMichele A, Chodosh LA and Schmitz KH: The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema. Contemporary Clinical Trials 61: 63-72, 2017.
124 Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ and Chodosh LA: Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy. Journal of Clinical Investigation 125: 2484-96, 2015.
10b Alvarez JV, Belka GK, Pan TC, Chen CC, Blankemeyer E, Alavi A, Karp JS and Chodosh LA: Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. Cancer Research 74: 7583-7598, 2014.
101 Feng Y, Pan TC, Pant DK, Chakrabarti KR, Alvarez JV, Ruth JR and Chodosh LA: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Cancer Discovery 4: 790-803, 2014.
15f Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou AY, Pant D, Grimley JS, Wandless TJ, DeMichele A, I-SPY 1 Trial Investigators and Chodosh LA: Par-4 down-regulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24: 30-44, 2013.
159 Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, Alvarez JV and Chodosh LA: Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes & Development 26: 2154-2168, 2012.
118 Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.
16f Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation Cell Metabolism 4: 475-490, 2006.
121 Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notarfrancesco K, Cardiff RD and Chodosh LA: The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.
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